GCK and GCKR

Number of citations of the paper that reports this interaction (PMID 10601273)
24

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		GCK	GCKR
Gene Name		glucokinase (hexokinase 4)	glucokinase (hexokinase 4) regulator
Image
Gene Ontology Annotations	Cellular Component	Nucleoplasm Mitochondrion Cytosol Actin Filament Secretory Granule Basal Cortex	Nucleoplasm Cytoplasm Mitochondrion Cytosol
	Molecular Function	Magnesium Ion Binding Glucokinase Activity Protein Binding ATP Binding Glucose Binding Fructokinase Activity Mannokinase Activity Protein Phosphatase Binding ADP Binding	Enzyme Inhibitor Activity Protein Binding Enzyme Binding Protein Domain Specific Binding Carbohydrate Binding Fructose-6-phosphate Binding
	Biological Process	Cellular Glucose Homeostasis Carbohydrate Metabolic Process Glycogen Biosynthetic Process Fructose 2,6-bisphosphate Metabolic Process Glucose Metabolic Process Glycolytic Process Regulation Of Glycolytic Process NADP Metabolic Process Positive Regulation Of Cytosolic Calcium Ion Concentration Hexose Transport Pathogenesis Regulation Of Glucose Transport Glucose Transport Second-messenger-mediated Signaling Endocrine Pancreas Development Positive Regulation Of Insulin Secretion Negative Regulation Of Epinephrine Secretion Cellular Response To Insulin Stimulus Cellular Response To Glucose Starvation Positive Regulation Of Phosphorylation Glucose Homeostasis Regulation Of Potassium Ion Transport Small Molecule Metabolic Process Cellular Response To Leptin Stimulus Negative Regulation Of Gluconeogenesis Positive Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Glycolytic Process Carbohydrate Phosphorylation Regulation Of Insulin Secretion Glucose 6-phosphate Metabolic Process Detection Of Glucose Transmembrane Transport Lipid Homeostasis Calcium Ion Import	Protein Import Into Nucleus, Translocation Cellular Glucose Homeostasis Carbohydrate Metabolic Process Hexose Transport Pathogenesis Response To Fructose Regulation Of Glucose Transport Glucose Transport Negative Regulation Of Glucokinase Activity Positive Regulation Of Glucokinase Activity Small Molecule Metabolic Process Urate Metabolic Process Transmembrane Transport Triglyceride Homeostasis
Pathways		Regulation of Glucokinase by Glucokinase Regulatory Protein SLC-mediated transmembrane transport Hexose transport Regulation of beta-cell development Myoclonic epilepsy of Lafora Glycogen storage diseases Regulation of gene expression in beta cells Glucose transport Metabolism of carbohydrates	Myoclonic epilepsy of Lafora Glycogen storage diseases Regulation of Glucokinase by Glucokinase Regulatory Protein Metabolism of carbohydrates Glucose transport SLC-mediated transmembrane transport Hexose transport
Drugs		Beta-D-Glucose 2-amino-N-(4-methyl-1,3-thiazol-2-yl)-5-[(4-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]benzamide 3-[(4-fluorophenyl)sulfanyl]-N-(4-methyl-1,3-thiazol-2-yl)-6-[(4-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]pyridine-2-carboxamide 2-(methylamino)-N-(4-methyl-1,3-thiazol-2-yl)-5-[(4-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]benzamide 2-AMINO-4-FLUORO-5-[(1-METHYL-1H-IMIDAZOL-2-YL)SULFANYL]-N-(1,3-THIAZOL-2-YL)BENZAMIDE
Diseases
GWAS		Fasting glucose-related traits ( 20081858) Fasting glucose-related traits (interaction with BMI) ( 22581228) Fasting plasma glucose ( 19060907) Glycated hemoglobin levels ( 20858683 19096518) Glycemic traits ( 23575436) Metabolic syndrome ( 22399527) Metabolite levels ( 21909109)	Breast size ( 22747683) C-reactive protein ( 18439548 21300955) Calcium levels ( 20705733) Cardiovascular disease risk factors ( 21943158) Cholesterol, total ( 20686565) Chronic kidney disease ( 20383146) Crohn's disease ( 21102463) Fasting glucose-related traits ( 20081858) Fasting glucose-related traits (interaction with BMI) ( 22581228) Fasting insulin-related traits ( 20081858) Fasting insulin-related traits (interaction with BMI) ( 22581228) Fasting plasma glucose ( 22508271) Hematological and biochemical traits ( 20139978) Hypertriglyceridemia ( 23505323 20657596) LDL cholesterol ( 18179892) Lipid metabolism phenotypes ( 19936222) Lipoprotein-associated phospholipase A2 activity and mass ( 23118302) Liver enzyme levels (gamma-glutamyl transferase) ( 22001757) Metabolic syndrome ( 22399527) Metabolic traits ( 19060910 21886157) Metabolite levels ( 21909109 22286219 22916037) Non-albumin protein levels ( 22558069) Palmitic acid (16:0) plasma levels ( 23362303) Palmitoleic acid (16:1n-7) plasma levels ( 23362303) Phospholipid levels (plasma) ( 21829377 22359512) Platelet counts ( 22139419) Serum albumin level ( 23022100) Serum total protein level ( 23022100) Sex hormone-binding globulin levels ( 22829776) Triglycerides ( 23726366 21909109 18193043 18193044 20864672 19060906 19060911 20139978 20686565) Triglycerides-Blood Pressure (TG-BP) ( 21386085) Two-hour glucose challenge ( 20081857) Urate levels ( 20884846 20139978 23263486) Uric acid levels ( 19503597) Waist Circumference - Triglycerides (WC-TG) ( 21386085) Waist circumference and related phenotypes ( 18454146)
Protein-Protein Interactions		4 interactors: GCKR INS PCNA PFKFB2	3 interactors: CDKN1A GCK TRAF2
Entrez ID		2645	2646
HPRD ID		00680	02909
Ensembl ID		ENSG00000106633	ENSG00000084734
Uniprot IDs		P35557 Q53Y25	F5H1P6 Q14397
PDB IDs		1GLK 1V4S 1V4T 3A0I 3F9M 3FGU 3FR0 3GOI 3H1V 3ID8 3IDH 3IMX 3QIC 3S41 3VEV 3VEY 3VF6 4DCH 4DHY 4ISE 4ISF 4ISG 4IWV 4IXC 4L3Q 4LC9 4MLE 4MLH	4BB9 4BBA
Enriched GO Terms of Interacting Partners?		Regulation Of Glucose Metabolic Process Positive Regulation Of Glucokinase Activity Regulation Of Carbohydrate Metabolic Process Positive Regulation Of Catalytic Activity Positive Regulation Of Kinase Activity Positive Regulation Of Transferase Activity Glucose Transport Hexose Transport Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of Peptide Secretion Regulation Of Glucose Transport Regulation Of Catalytic Activity Positive Regulation Of Hormone Secretion Response To Organic Substance Lipid Homeostasis Positive Regulation Of Cellular Metabolic Process Regulation Of Kinase Activity Carbohydrate Transport Positive Regulation Of Deoxyribonuclease Activity Regulation Of DNA Replication Positive Regulation Of Phosphorylation Glucose Metabolic Process Positive Regulation Of DNA Metabolic Process Negative Regulation Of Glycogen Catabolic Process Leading Strand Elongation Carbohydrate Metabolic Process Response To Carbohydrate Positive Regulation Of Protein Secretion Regulation Of Insulin Secretion Hexose Metabolic Process Positive Regulation Of Metabolic Process Glucose Homeostasis Pathogenesis Negative Regulation Of Respiratory Burst Involved In Inflammatory Response Negative Regulation Of NAD(P)H Oxidase Activity Regulation Of Peptide Hormone Secretion Monosaccharide Metabolic Process Regulation Of Phosphorylation Regulation Of Hormone Secretion Homeostatic Process Positive Regulation Of Brown Fat Cell Differentiation Glucose Catabolic Process Regulation Of Phosphorus Metabolic Process Regulation Of Brown Fat Cell Differentiation Negative Regulation Of Glucokinase Activity Regulation Of NAD(P)H Oxidase Activity Negative Regulation Of Feeding Behavior Positive Regulation Of Secretion Positive Regulation Of Protein Transport Positive Regulation Of Respiratory Burst	Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Positive Regulation Of Transferase Activity Regulation Of Protein Transport Regulation Of Establishment Of Protein Localization Positive Regulation Of JUN Kinase Activity Positive Regulation Of Protein Phosphorylation Regulation Of Protein Kinase Activity Regulation Of JUN Kinase Activity Regulation Of Kinase Activity Regulation Of Protein Localization Innate Immune Response Positive Regulation Of Phosphorylation Positive Regulation Of Protein Modification Process Positive Regulation Of JNK Cascade Regulation Of Cellular Localization Regulation Of Protein Phosphorylation Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of Cellular Protein Metabolic Process Regulation Of JNK Cascade Positive Regulation Of Protein Metabolic Process Immune Response Regulation Of Phosphorylation Regulation Of Stress-activated MAPK Cascade Defense Response Positive Regulation Of MAP Kinase Activity Cellular Response To Extracellular Stimulus Regulation Of Phosphorus Metabolic Process Cellular Response To Stress Positive Regulation Of Catalytic Activity Detection Of Glucose Activation Of Protein Kinase Activity Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of MAP Kinase Activity Positive Regulation Of Cell Activation Intracellular Signal Transduction Cellular Response To Organic Substance Intestinal Epithelial Cell Maturation Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Epinephrine Secretion Immune System Process Negative Regulation Of Glial Cell Apoptotic Process Regulation Of Lymphocyte Activation Regulation Of Protein Secretion Regulation Of Protein Metabolic Process Cellular Response To UV-B Positive Regulation Of MAPK Cascade Regulation Of Catalytic Activity Response To Extracellular Stimulus
Tagcloud ?		15del26 a1c acanthosis boy department dysmorphic exam fasting glucose height hemoglobin hyperglycemia increment l maturity mmol mody2 mother mu mutational nigricans ogtt proband referred segregated shifted stable stature unremarkable	aetiology ancestry college direction equivocal european europeans genotyped gout hlf inconsistency inhbc loci maaori maf meeting obvious opposing pacific pdzk1 polynesian prkag2 replicated rheumatology sizes slc16a9 slc22a11 urate zealand
Tagcloud (Difference) ?		15del26 a1c acanthosis boy department dysmorphic exam fasting glucose height hemoglobin hyperglycemia increment l maturity mmol mody2 mother mu mutational nigricans ogtt proband referred segregated shifted stable stature unremarkable	aetiology ancestry college direction equivocal european europeans genotyped gout hlf inconsistency inhbc loci maaori maf meeting obvious opposing pacific pdzk1 polynesian prkag2 replicated rheumatology sizes slc16a9 slc22a11 urate zealand
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