PSENEN and TMED10

Number of citations of the paper that reports this interaction (PMID 16641999)
75

Data Source:
HPRD (in vivo)

		PSENEN	TMED10
Gene Name		presenilin enhancer gamma secretase subunit	transmembrane emp24-like trafficking protein 10 (yeast)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Golgi Cisterna Membrane Gamma-secretase Complex	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Cis-Golgi Network Plasma Membrane Integral Component Of Membrane COPI-coated Vesicle Trans-Golgi Network Transport Vesicle Transport Vesicle Membrane Secretory Granule Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Melanosome Zymogen Granule Membrane Extracellular Vesicular Exosome Gamma-secretase Complex
	Molecular Function	Protein Binding	Protein Binding Syntaxin Binding Protein Complex Binding
	Biological Process	Membrane Protein Ectodomain Proteolysis Notch Signaling Pathway Notch Receptor Processing Axon Guidance Protein Processing Membrane Protein Intracellular Domain Proteolysis Amyloid Precursor Protein Catabolic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Catalytic Activity Neurotrophin TRK Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Apoptotic Signaling Pathway	Kidney Development Intracellular Protein Transport ER To Golgi Vesicle-mediated Transport Retrograde Vesicle-mediated Transport, Golgi To ER Golgi Organization Cargo Loading Into Vesicle COPI-coated Vesicle Budding Response To Alkaloid Regulated Secretory Pathway Vesicle Targeting, To, From Or Within Golgi COPI Coating Of Golgi Vesicle COPII Vesicle Coating Protein Oligomerization Regulation Of Beta-amyloid Formation
Pathways		Signaling by NOTCH1 HD Domain Mutants in Cancer Axon guidance Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Signaling by NOTCH2 EPH-ephrin mediated repulsion of cells Signaling by NOTCH1 EPH-Ephrin signaling Signaling by NOTCH1 in Cancer Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants FBXW7 Mutants and NOTCH1 in Cancer Signaling by NOTCH4 Regulated proteolysis of p75NTR Signalling by NGF Cell death signalling via NRAGE, NRIF and NADE Signaling by NOTCH p75 NTR receptor-mediated signalling Signaling by ERBB4 NOTCH2 Activation and Transmission of Signal to the Nucleus Activated NOTCH1 Transmits Signal to the Nucleus Nuclear signaling by ERBB4 NRIF signals cell death from the nucleus Signaling by NOTCH1 PEST Domain Mutants in Cancer Signaling by NOTCH3 Constitutive Signaling by NOTCH1 PEST Domain Mutants
Drugs
Diseases
GWAS			Height ( 19343178)
Protein-Protein Interactions		6 interactors: APH1A NCSTN PSEN1 PSEN2 THBD TMED10	15 interactors: APH1A ARCN1 ARF1 COPA COPB1 COPB2 COPE COPG1 COPZ1 DHODH GORASP2 NCSTN PSENEN SEC23B TMED2
Entrez ID		55851	10972
HPRD ID		06362	12013
Ensembl ID			ENSG00000170348
Uniprot IDs		Q9NZ42	B4DL12 P49755
PDB IDs
Enriched GO Terms of Interacting Partners?		Amyloid Precursor Protein Catabolic Process Amyloid Precursor Protein Metabolic Process Membrane Protein Ectodomain Proteolysis Notch Receptor Processing Membrane Protein Proteolysis Beta-amyloid Metabolic Process Membrane Protein Intracellular Domain Proteolysis Notch Signaling Pathway Positive Regulation Of Coagulation Protein Processing Ephrin Receptor Signaling Pathway Locomotion Peptide Metabolic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Movement Of Cell Or Subcellular Component Positive Regulation Of Cell Death Regulation Of Epidermal Growth Factor-activated Receptor Activity Neurotrophin TRK Receptor Signaling Pathway Response To External Stimulus Neurotrophin Signaling Pathway Endoplasmic Reticulum Calcium Ion Homeostasis Cellular Amide Metabolic Process Dorsal/ventral Neural Tube Patterning T Cell Aggregation T Cell Activation Lymphocyte Aggregation Leukocyte Aggregation Brain Morphogenesis Neuron Development Vesicle Targeting Apoptotic Process Leukocyte Cell-cell Adhesion Programmed Cell Death Homotypic Cell-cell Adhesion Cell Death Death Apoptotic Signaling Pathway Neuron Differentiation Thymus Development Neural Tube Patterning Response To Organic Substance Regulation Of Protein Tyrosine Kinase Activity Axon Guidance Lymphocyte Activation T Cell Activation Involved In Immune Response Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Somitogenesis Leukocyte Activation	COPI-coated Vesicle Budding COPI Coating Of Golgi Vesicle Golgi Vesicle Budding Vesicle Targeting, To, From Or Within Golgi Localization Within Membrane Vesicle Targeting Retrograde Vesicle-mediated Transport, Golgi To ER Membrane Budding Golgi Vesicle Transport Establishment Of Vesicle Localization Vesicle Organization Vesicle Localization Establishment Of Organelle Localization Organelle Localization Membrane Organization Protein Transport Vesicle-mediated Transport Establishment Of Protein Localization Intracellular Transport Intracellular Protein Transport Protein Localization Intra-Golgi Vesicle-mediated Transport Establishment Of Localization In Cell Amyloid Precursor Protein Catabolic Process Membrane Protein Intracellular Domain Proteolysis Membrane Protein Ectodomain Proteolysis Amyloid Precursor Protein Metabolic Process Cellular Localization Notch Receptor Processing Cellular Protein Localization Membrane Protein Proteolysis Organelle Organization Transport Ephrin Receptor Signaling Pathway ER To Golgi Vesicle-mediated Transport Notch Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Protein Processing Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Cerebellar Purkinje Cell Layer Maturation Apoptotic Signaling Pathway Axon Guidance Cerebellum Maturation 'de Novo' UMP Biosynthetic Process Body Fluid Secretion Axonogenesis Establishment Of Golgi Localization
Tagcloud ?		ad al amyloidosis attenuates burden ca1 calorie cerebral cr endogenously enhancer feeding female hippocampal indicates influences intake involve libitum neuron pathology reduces reductions restriction secretase sustained tg2576 translatable	aiming aip alignment boar brms1 chordc1 clues cops6 csde1 csfv ddx5 domestic fever gnb2l1 hemorrhagic hspa8 interactive metap2 nav1 ncbi ns5a phf5a polr1c ppp2r3c psmc3 suvec swine tmem70 y2h
Tagcloud (Difference) ?		ad al amyloidosis attenuates burden ca1 calorie cerebral cr endogenously enhancer feeding female hippocampal indicates influences intake involve libitum neuron pathology reduces reductions restriction secretase sustained tg2576 translatable	aiming aip alignment boar brms1 chordc1 clues cops6 csde1 csfv ddx5 domestic fever gnb2l1 hemorrhagic hspa8 interactive metap2 nav1 ncbi ns5a phf5a polr1c ppp2r3c psmc3 suvec swine tmem70 y2h
Tagcloud (Intersection) ?