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PSENEN
Description
presenilin enhancer, gamma-secretase subunit
Image
GO Annotations
Cellular Component
Golgi Membrane
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Golgi Apparatus
Plasma Membrane
Endosome Membrane
Membrane
Golgi Cisterna Membrane
Presynaptic Membrane
Gamma-secretase Complex
Molecular Function
Protein Binding
Enzyme Binding
Endopeptidase Activator Activity
Biological Process
Membrane Protein Ectodomain Proteolysis
Notch Signaling Pathway
Notch Receptor Processing
Positive Regulation Of Endopeptidase Activity
Protein Processing
Membrane Protein Intracellular Domain Proteolysis
Amyloid-beta Formation
Amyloid Precursor Protein Metabolic Process
Amyloid Precursor Protein Catabolic Process
Pathways
Nuclear signaling by ERBB4
Regulated proteolysis of p75NTR
NRIF signals cell death from the nucleus
Activated NOTCH1 Transmits Signal to the Nucleus
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
NOTCH2 Activation and Transmission of Signal to the Nucleus
EPH-ephrin mediated repulsion of cells
NOTCH3 Activation and Transmission of Signal to the Nucleus
NOTCH4 Activation and Transmission of Signal to the Nucleus
Noncanonical activation of NOTCH3
Amyloid fiber formation
TGFBR3 PTM regulation
Drugs
E-2012
Diseases
Acne inversa; Hidradenitis supprativa
GWAS
Brain morphology (MOSTest) (
32665545
)
Refractive error (
32231278
)
Interacting Genes
10 interacting genes:
APH1A
CRB3
CREB3
NCSTN
PSEN1
PSEN2
SLC10A2
SLC10A6
THBD
TMED10
Entrez ID
55851
HPRD ID
06362
Ensembl ID
ENSG00000205155
Uniprot IDs
Q9NZ42
PDB IDs
5A63
5FN2
5FN3
5FN4
5FN5
6IDF
6IYC
6LQG
6LR4
7C9I
7D8X
7Y5T
7Y5X
7Y5Z
8IM7
8K8E
8KCO
8KCP
8KCS
8KCT
8KCU
8OQY
8OQZ
8X52
8X53
8X54
Enriched GO Terms of Interacting Partners
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Gamma-secretase Complex
Notch Receptor Processing
Amyloid-beta Formation
Amyloid Precursor Protein Catabolic Process
Membrane Protein Ectodomain Proteolysis
Amyloid-beta Metabolic Process
Amyloid Precursor Protein Metabolic Process
Aspartic Endopeptidase Activity, Intramembrane Cleaving
Membrane Protein Proteolysis
Protein Processing
Synaptic Membrane
Notch Signaling Pathway
Protein Maturation
Golgi Membrane
Presynaptic Membrane
Synaptic Vesicle
Growth Factor Receptor Binding
Bile Acid:sodium Symporter Activity
Endoplasmic Reticulum Membrane
Early Endosome
Membrane Protein Intracellular Domain Proteolysis
Golgi Apparatus
Vesicle Targeting
Plasma Membrane
Endopeptidase Activator Activity
Bile Acid And Bile Salt Transport
Endoplasmic Reticulum
Membrane
Positive Regulation Of Coagulation
Proteolysis
Azurophil Granule Membrane
Carboxylic Acid Transport
Organic Acid Transport
Cerebellum Development
Negative Regulation Of Core Promoter Binding
Positive Regulation Of Deacetylase Activity
Cytosol To ERGIC Protein Transport
Protein Localization To ERGIC
COPI-coated Vesicle Budding
Amyloid Precursor Protein Biosynthetic Process
Sodium-dependent Organic Anion Transmembrane Transporter Activity
Sodium-dependent Organic Anion Transport
Protein-containing Complex
Organic Anion Transport
ATPase Binding
Smooth Endoplasmic Reticulum Calcium Ion Homeostasis
Endopeptidase Activity
Cajal-Retzius Cell Differentiation
Blood Coagulation, Common Pathway
Symporter Activity
Tagcloud
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