PSENEN

Gene Name		presenilin enhancer gamma secretase subunit
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Golgi Cisterna Membrane Gamma-secretase Complex
	Molecular Function	Protein Binding
	Biological Process	Membrane Protein Ectodomain Proteolysis Notch Signaling Pathway Notch Receptor Processing Axon Guidance Protein Processing Membrane Protein Intracellular Domain Proteolysis Amyloid Precursor Protein Catabolic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Catalytic Activity Neurotrophin TRK Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Apoptotic Signaling Pathway
Pathways		Signaling by NOTCH1 HD Domain Mutants in Cancer Axon guidance Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Signaling by NOTCH2 EPH-ephrin mediated repulsion of cells Signaling by NOTCH1 EPH-Ephrin signaling Signaling by NOTCH1 in Cancer Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants FBXW7 Mutants and NOTCH1 in Cancer Signaling by NOTCH4 Regulated proteolysis of p75NTR Signalling by NGF Cell death signalling via NRAGE, NRIF and NADE Signaling by NOTCH p75 NTR receptor-mediated signalling Signaling by ERBB4 NOTCH2 Activation and Transmission of Signal to the Nucleus Activated NOTCH1 Transmits Signal to the Nucleus Nuclear signaling by ERBB4 NRIF signals cell death from the nucleus Signaling by NOTCH1 PEST Domain Mutants in Cancer Signaling by NOTCH3 Constitutive Signaling by NOTCH1 PEST Domain Mutants
Drugs
Diseases
GWAS
Protein-protein Interactions		6 interactors: APH1A NCSTN PSEN1 PSEN2 THBD TMED10
Entrez ID		55851
HPRD ID		06362
Ensembl ID
Uniprot IDs		Q9NZ42
PDB IDs
Enriched GO Terms of Interacting Partners?		Amyloid Precursor Protein Catabolic Process Amyloid Precursor Protein Metabolic Process Membrane Protein Ectodomain Proteolysis Notch Receptor Processing Membrane Protein Proteolysis Beta-amyloid Metabolic Process Membrane Protein Intracellular Domain Proteolysis Notch Signaling Pathway Positive Regulation Of Coagulation Protein Processing Ephrin Receptor Signaling Pathway Locomotion Peptide Metabolic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Movement Of Cell Or Subcellular Component Positive Regulation Of Cell Death Regulation Of Epidermal Growth Factor-activated Receptor Activity Neurotrophin TRK Receptor Signaling Pathway Response To External Stimulus Neurotrophin Signaling Pathway Endoplasmic Reticulum Calcium Ion Homeostasis Cellular Amide Metabolic Process Dorsal/ventral Neural Tube Patterning T Cell Aggregation T Cell Activation Lymphocyte Aggregation Leukocyte Aggregation Brain Morphogenesis Neuron Development Vesicle Targeting Apoptotic Process Leukocyte Cell-cell Adhesion Programmed Cell Death Homotypic Cell-cell Adhesion Cell Death Death Apoptotic Signaling Pathway Neuron Differentiation Thymus Development Neural Tube Patterning Response To Organic Substance Regulation Of Protein Tyrosine Kinase Activity Axon Guidance Lymphocyte Activation T Cell Activation Involved In Immune Response Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Somitogenesis Leukocyte Activation
Tagcloud ?		ad al amyloidosis attenuates burden ca1 calorie cerebral cr endogenously enhancer feeding female hippocampal indicates influences intake involve libitum neuron pathology reduces reductions restriction secretase sustained tg2576 translatable