PSENEN and THBD

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		PSENEN	THBD
Gene Name		presenilin enhancer gamma secretase subunit	thrombomodulin
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Golgi Cisterna Membrane Gamma-secretase Complex	Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane Cell Surface
	Molecular Function	Protein Binding	Receptor Activity Transmembrane Signaling Receptor Activity Calcium Ion Binding Protein Binding
	Biological Process	Membrane Protein Ectodomain Proteolysis Notch Signaling Pathway Notch Receptor Processing Axon Guidance Protein Processing Membrane Protein Intracellular Domain Proteolysis Amyloid Precursor Protein Catabolic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Catalytic Activity Neurotrophin TRK Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Apoptotic Signaling Pathway	Signal Transduction Female Pregnancy Blood Coagulation Response To X-ray Negative Regulation Of Platelet Activation Negative Regulation Of Blood Coagulation Response To Lipopolysaccharide Leukocyte Migration Response To CAMP Negative Regulation Of Fibrinolysis
Pathways		Signaling by NOTCH1 HD Domain Mutants in Cancer Axon guidance Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Signaling by NOTCH2 EPH-ephrin mediated repulsion of cells Signaling by NOTCH1 EPH-Ephrin signaling Signaling by NOTCH1 in Cancer Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants FBXW7 Mutants and NOTCH1 in Cancer Signaling by NOTCH4 Regulated proteolysis of p75NTR Signalling by NGF Cell death signalling via NRAGE, NRIF and NADE Signaling by NOTCH p75 NTR receptor-mediated signalling Signaling by ERBB4 NOTCH2 Activation and Transmission of Signal to the Nucleus Activated NOTCH1 Transmits Signal to the Nucleus Nuclear signaling by ERBB4 NRIF signals cell death from the nucleus Signaling by NOTCH1 PEST Domain Mutants in Cancer Signaling by NOTCH3 Constitutive Signaling by NOTCH1 PEST Domain Mutants	Common Pathway Formation of Fibrin Clot (Clotting Cascade) Cell surface interactions at the vascular wall
Drugs			Drotrecogin alfa Ibuprofen
Diseases
GWAS
Protein-Protein Interactions		6 interactors: APH1A NCSTN PSEN1 PSEN2 THBD TMED10	5 interactors: F2 PF4 PROC PSENEN SERPINA5
Entrez ID		55851	7056
HPRD ID		06362	01764
Ensembl ID			ENSG00000178726
Uniprot IDs		Q9NZ42	P07204
PDB IDs			1ADX 1DQB 1DX5 1EGT 1FGD 1FGE 1HLT 1TMR 1ZAQ 2ADX 3GIS
Enriched GO Terms of Interacting Partners?		Amyloid Precursor Protein Catabolic Process Amyloid Precursor Protein Metabolic Process Membrane Protein Ectodomain Proteolysis Notch Receptor Processing Membrane Protein Proteolysis Beta-amyloid Metabolic Process Membrane Protein Intracellular Domain Proteolysis Notch Signaling Pathway Positive Regulation Of Coagulation Protein Processing Ephrin Receptor Signaling Pathway Locomotion Peptide Metabolic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Movement Of Cell Or Subcellular Component Positive Regulation Of Cell Death Regulation Of Epidermal Growth Factor-activated Receptor Activity Neurotrophin TRK Receptor Signaling Pathway Response To External Stimulus Neurotrophin Signaling Pathway Endoplasmic Reticulum Calcium Ion Homeostasis Cellular Amide Metabolic Process Dorsal/ventral Neural Tube Patterning T Cell Aggregation T Cell Activation Lymphocyte Aggregation Leukocyte Aggregation Brain Morphogenesis Neuron Development Vesicle Targeting Apoptotic Process Leukocyte Cell-cell Adhesion Programmed Cell Death Homotypic Cell-cell Adhesion Cell Death Death Apoptotic Signaling Pathway Neuron Differentiation Thymus Development Neural Tube Patterning Response To Organic Substance Regulation Of Protein Tyrosine Kinase Activity Axon Guidance Lymphocyte Activation T Cell Activation Involved In Immune Response Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Somitogenesis Leukocyte Activation	Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Wound Healing Peptidyl-glutamic Acid Carboxylation Response To Wounding Leukocyte Migration Locomotion Negative Regulation Of Blood Coagulation Negative Regulation Of Coagulation Negative Regulation Of Wound Healing Movement Of Cell Or Subcellular Component Regulation Of Blood Coagulation Positive Regulation Of Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Regulation Of Wound Healing Cell Migration Cell Motility Negative Regulation Of Cytolysis Platelet Activation Post-translational Protein Modification Negative Regulation Of Megakaryocyte Differentiation Negative Regulation Of MHC Class II Biosynthetic Process Negative Regulation Of Hematopoietic Progenitor Cell Differentiation Response To Stress Negative Regulation Of Fibrinolysis Negative Regulation Of Proteolysis Regulation Of Apoptotic Process Negative Regulation Of Protein Processing Proteolysis Positive Regulation Of Macrophage Differentiation Amyloid Precursor Protein Catabolic Process Regulation Of Cell Death Regulation Of Protein Processing Regulation Of Fibrinolysis Positive Regulation Of CAMP-mediated Signaling Inflammatory Response Blood Coagulation, Intrinsic Pathway Negative Regulation Of Astrocyte Differentiation Fusion Of Sperm To Egg Plasma Membrane Membrane Protein Intracellular Domain Proteolysis Negative Regulation Of Platelet Activation Positive Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Regulation Of Megakaryocyte Differentiation Plasma Membrane Fusion Membrane Protein Ectodomain Proteolysis Amyloid Precursor Protein Metabolic Process Regulation Of CAMP-mediated Signaling Notch Receptor Processing Response To Stimulus Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol
Tagcloud ?		ad al amyloidosis attenuates burden ca1 calorie cerebral cr endogenously enhancer feeding female hippocampal indicates influences intake involve libitum neuron pathology reduces reductions restriction secretase sustained tg2576 translatable	acat acyltransferase alox5ap arachidonate ath atherosclerotic cbs cysthathionenine deceased gathered genomelab gexp hcats irs1 lcat ldlr lecithin lipoxygenase lpl malaysian metallopeptidase methylenetetrahydrofolate mmp9 mortem mthfr ncat predetermined tgfbr2 thrombomodulin
Tagcloud (Difference) ?		ad al amyloidosis attenuates burden ca1 calorie cerebral cr endogenously enhancer feeding female hippocampal indicates influences intake involve libitum neuron pathology reduces reductions restriction secretase sustained tg2576 translatable	acat acyltransferase alox5ap arachidonate ath atherosclerotic cbs cysthathionenine deceased gathered genomelab gexp hcats irs1 lcat ldlr lecithin lipoxygenase lpl malaysian metallopeptidase methylenetetrahydrofolate mmp9 mortem mthfr ncat predetermined tgfbr2 thrombomodulin
Tagcloud (Intersection) ?