PHF20L1 and WWP1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		PHF20L1	WWP1
Description		PHD finger protein 20 like 1	WW domain containing E3 ubiquitin protein ligase 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm NSL Complex	Ubiquitin Ligase Complex Nucleus Cytoplasm Cytosol Plasma Membrane Membrane Extracellular Exosome Anchoring Junction
	Molecular Function	Protein Binding Zinc Ion Binding Metal Ion Binding Methylation-dependent Protein Binding	Ubiquitin-protein Transferase Activity Protein Binding Transferase Activity Ubiquitin Protein Ligase Activity
	Biological Process	Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Protein Catabolic Process	Ubiquitin-dependent Protein Catabolic Process Signal Transduction Central Nervous System Development Protein Ubiquitination Monoatomic Ion Transmembrane Transport Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of DNA-templated Transcription Symbiont Entry Into Host Cell
Pathways		Formation of WDR5-containing histone-modifying complexes	Downregulation of ERBB4 signaling Stimuli-sensing channels Regulation of RUNX2 expression and activity Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Body fat percentage ( 31752434) Mean reticulocyte volume ( 32888494) Metabolite levels ( 23823483) Thyroid stimulating hormone levels ( 32769997) Type 1 diabetes (age at diagnosis) ( 33179336)	Estimated glomerular filtration rate ( 31152163)
Interacting Genes		10 interacting genes: APP CASP10 ELAVL4 KDM1A LRRK2 LYAR TERT UBC WWP1 ZNF471	59 interacting genes: ASH2L ATN1 CBL CDKN1B CLCN5 CPSF6 DAG1 DAZAP2 DIDO1 ENTREP1 EWSR1 FBXL18 HSPB1 IKBKG IL2RG IL6R KLF2 LAPTM5 LATS1 LNX1 LZTR1 MACROH2A2 MIR19A MIR19B1 NFE2 NOTCH1 PCBD1 PHF20L1 PRKAA2 PRRG4 PTEN PYGM RASA1 RNF11 RTN4 RUNX1 SCNN1A SFTPC SHANK3 SLC2A1 SMAD3 SMAD5 STAT6 TFAP2A TGIF1 TP53 TP53BP2 TRAF4 TXNIP UBC UBE2D1 UBE2D2 UBE2D3 UBE2L3 WASL WBP1 WBP2 YWHAQ ZNF638
Entrez ID		51105	11059
HPRD ID		15125	03811
Ensembl ID		ENSG00000129292	ENSG00000123124
Uniprot IDs		A0A0A0MQS0 A0A0A8K9A6 A8MW92 F8W9L8 Q9H8G4	Q9H0M0
PDB IDs		2EQM 2EQU 2JTF 6L0X 6L10 6L1C 6L1F 6L1I 6L1P	1ND7 2OP7 5HPS 5HPT 6J1X 6J1Y 8EI4 9EQK
Enriched GO Terms of Interacting Partners?		Golgi-associated Vesicle Growth Cone Cellular Response To Catecholamine Stimulus Cellular Response To Manganese Ion Perikaryon Regulation Of Apoptotic Signaling Pathway Response To Catecholamine Response To Manganese Ion Macromolecule Metabolic Process Positive Regulation Of Endocytosis Telomeric DNA Binding Neuron Maturation Regulation Of Intrinsic Apoptotic Signaling Pathway Locomotory Behavior Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Amyloid-beta Complex Cell Projection Morphogenesis Growth Cone Lamellipodium Regulation Of Neuron Apoptotic Process Regulation Of Response To Calcium Ion Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Amylin Binding Neuron Projection Morphogenesis Positive Regulation Of Toll Signaling Pathway Regulation Of CAMP/PKA Signal Transduction Cellular Response To CAMP Modulation Of Excitatory Postsynaptic Potential TERT-RMRP Complex Template-free RNA Nucleotidyltransferase Negative Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Transdifferentiation RNA-directed RNA Polymerase Complex Positive Regulation Of Stem Cell Proliferation SiRNA Transcription Regulation Of Neuroblast Proliferation Cellular Response To Curcumin Caveola Neck GTP-dependent Protein Kinase Activity Wnt Signalosome Assembly Myeloid Cell Development Negative Regulation Of RNA Metabolic Process Regulation Of Endocytosis Regulation Of Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Regulation Of Wnt Signaling Pathway Acetylcholine Receptor Activator Activity Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of RNA Metabolic Process Response To Metal Ion	WW Domain Binding Ubiquitin Protein Ligase Binding Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process Regulation Of Programmed Cell Death Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Nucleoplasm Negative Regulation Of Signal Transduction Regulation Of Apoptotic Process Regulation Of Organ Growth Regulation Of Extracellular Matrix Assembly Regulation Of DNA-templated Transcription Response To Hormone Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Intracellular Signal Transduction Negative Regulation Of Metabolic Process Negative Regulation Of Programmed Cell Death Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Developmental Process Regulation Of Signal Transduction Cell Fate Commitment Positive Regulation Of Biosynthetic Process Regulation Of Extracellular Matrix Organization Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Multicellular Organismal Development Modification-dependent Protein Catabolic Process Identical Protein Binding Negative Regulation Of DNA-templated Transcription Ubiquitin Conjugating Enzyme Activity Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Metabolic Process Negative Regulation Of Apoptotic Process Nucleus Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Developmental Process Apoptotic Process Ubiquitin Ligase Activator Activity Enzyme Binding Regulation Of Protein Metabolic Process
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