APIP and NIF3L1

Number of citations of the paper that reports this interaction (PMID 19060904)
157

Data Source:
BioGRID (two hybrid)

		APIP	NIF3L1
Gene Name		APAF1 interacting protein	NIF3 NGG1 interacting factor 3-like 1 (S. cerevisiae)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm	Cytoplasm Mitochondrion
	Molecular Function	Protein Binding Zinc Ion Binding Identical Protein Binding Methylthioribulose 1-phosphate Dehydratase Activity	GTP Cyclohydrolase I Activity Protein Binding GTP Binding Transcription Factor Binding Metal Ion Binding
	Biological Process	Sulfur Amino Acid Metabolic Process Polyamine Metabolic Process Apoptotic Process L-methionine Biosynthetic Process From S-adenosylmethionine L-methionine Biosynthetic Process From Methylthioadenosine Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Apoptotic Process Small Molecule Metabolic Process Regulation Of ERK1 And ERK2 Cascade	7,8-dihydroneopterin 3'-triphosphate Biosynthetic Process Positive Regulation Of Transcription, DNA-templated
Pathways		Metabolism of polyamines Sulfur amino acid metabolism Methionine salvage pathway Metabolism of amino acids and derivatives
Drugs
Diseases
GWAS		Chronic obstructive pulmonary disease-related biomarkers ( 23144326) Cystic fibrosis severity ( 21602797)
Protein-Protein Interactions		17 interactors: APAF1 C6orf165 IMPDH2 LNX1 NIF3L1 NUDT18 PDZD4 PPP1CC PSMA1 SDCBP SKP1 TNPO2 TSC22D4 VIM VPS25 WDYHV1 ZBTB25	64 interactors: AP5B1 APIP ARPIN BEND7 CCDC102B CCDC85B CDKN2B CDKN2C COIL COPS2 CUTC DCDC2 DCTD DCTPP1 DHPS DMC1 DMRTB1 DUSP23 DYNLT3 EIF5A2 ENOX1 EPHB6 FAM49B FXR2 GNMT GRB2 KCTD17 KRT15 KXD1 LAMTOR3 LMO2 MAGEA11 MAPRE2 MLXIPL NATD1 NME1 NOL3 NUDT14 NUDT21 ORC5 PAICS PCBD1 PRTFDC1 RABAC1 RAD54B RPIA S100A1 SAT1 SNF8 STAT3 STK16 SULT1A2 SULT1A3 SYT17 THOC7 TIFA TRAF2 TRIM21 TRIP13 TSC22D4 VIM YES1 YWHAQ ZBED1
Entrez ID		51074	60491
HPRD ID		14725	10424
Ensembl ID		ENSG00000149089	ENSG00000196290
Uniprot IDs		J3KN82 Q96GX9	Q9GZT8
PDB IDs
Enriched GO Terms of Interacting Partners?		Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Catabolic Process Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition GDP Catabolic Process Response To G1 DNA Damage Checkpoint Signaling DGDP Catabolic Process DADP Catabolic Process Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Positive Regulation Of Proteolysis Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process 7,8-dihydroneopterin 3'-triphosphate Biosynthetic Process Regulation Of Ubiquitin-protein Transferase Activity Cellular Macromolecule Catabolic Process Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Protein Targeting To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Dihydrobiopterin Metabolic Process Positive Regulation Of Extracellular Vesicular Exosome Assembly GMP Biosynthetic Process Positive Regulation Of Protein Ubiquitination Regulation Of Extracellular Vesicular Exosome Assembly Purine Ribonucleoside Diphosphate Catabolic Process Endosome Transport Via Multivesicular Body Sorting Pathway Nucleobase-containing Small Molecule Catabolic Process Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Cellular Protein Catabolic Process Late Endosome To Vacuole Transport Viral Process G1/S Transition Of Mitotic Cell Cycle Bergmann Glial Cell Differentiation Ribonucleoside Diphosphate Catabolic Process Regulation Of Metabolic Process Protein Ubiquitination Circadian Rhythm Regulation Of Apoptotic DNA Fragmentation GMP Metabolic Process Nucleoside Diphosphate Catabolic Process Protein Modification By Small Protein Conjugation Positive Regulation Of Exosomal Secretion Regulation Of Exosomal Secretion Deoxyribonucleoside Diphosphate Metabolic Process Regulation Of Protein Ubiquitination Substrate-dependent Cell Migration, Cell Extension Histone H2A Monoubiquitination	Protein Oligomerization Nucleobase-containing Compound Metabolic Process Protein Tetramerization Cellular Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Nucleobase-containing Small Molecule Metabolic Process Nitrogen Compound Metabolic Process Nucleoside Metabolic Process 3'-phosphoadenosine 5'-phosphosulfate Metabolic Process Protein Complex Assembly Protein Homotetramerization Purine Nucleoside Metabolic Process Protein Homooligomerization Peptidyl-lysine Modification To Peptidyl-hypusine Polyamine Metabolic Process Polyamine Catabolic Process Ribose Phosphate Metabolic Process Reciprocal Meiotic Recombination Nucleotide Metabolic Process Amine Metabolic Process Ribonucleotide Metabolic Process Biosynthetic Process Cellular Metabolic Process Purine Nucleotide Metabolic Process S-adenosylmethionine Metabolic Process Methionine Metabolic Process Regulation Of Protein Homodimerization Activity Cellular Component Assembly Sulfation Sulfur Compound Metabolic Process Positive Regulation Of T Cell Activation Gene Expression Amine Biosynthetic Process Oocyte Maturation Positive Regulation Of Homotypic Cell-cell Adhesion Transcription, DNA-templated Regulation Of Glycolytic Process Meiosis I Organophosphate Metabolic Process Male Meiosis I Cell Cycle Process Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Cell-cell Adhesion RNA Biosynthetic Process Response To Injury Involved In Regulation Of Muscle Adaptation Deoxyhypusine Biosynthetic Process From Spermidine Glucose Mediated Signaling Pathway Polyamine Homeostasis Response To Brefeldin A
Tagcloud ?		11p12 14q24 6q12 9p24 abcd4 acyp1 amplifications cd109 cd274 commd9 coq6 cttn fjx1 hbld1 interscience jdp2 jpages ltbp2 myo6 otscc pdhx pinpointed ppfia1 q14 rln1 slc1a1 suppmat trim44 znf410
Tagcloud (Difference) ?		11p12 14q24 6q12 9p24 abcd4 acyp1 amplifications cd109 cd274 commd9 coq6 cttn fjx1 hbld1 interscience jdp2 jpages ltbp2 myo6 otscc pdhx pinpointed ppfia1 q14 rln1 slc1a1 suppmat trim44 znf410
Tagcloud (Intersection) ?