APIP and NIF3L1

Number of citations of the paper that reports this interaction (PubMedID 19060904)
32

Data Source:
BioGRID (two hybrid)

		APIP	NIF3L1
Description		APAF1 interacting protein	NGG1 interacting factor 3 like 1
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol	Nucleus Cytoplasm Mitochondrion
	Molecular Function	Protein Binding Zinc Ion Binding Lyase Activity Identical Protein Binding Methylthioribulose 1-phosphate Dehydratase Activity Metal Ion Binding	Protein Binding Identical Protein Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding
	Biological Process	Apoptotic Process Amino Acid Biosynthetic Process Methionine Biosynthetic Process L-methionine Salvage From Methylthioadenosine Negative Regulation Of Apoptotic Process Protein Homotetramerization Pyroptotic Inflammatory Response Regulation Of ERK1 And ERK2 Cascade	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Neuron Differentiation Positive Regulation Of DNA-templated Transcription
Pathways		Formation of apoptosome Methionine salvage pathway Regulation of the apoptosome activity
Drugs
Diseases
GWAS		Chronic obstructive pulmonary disease-related biomarkers ( 23144326) Cystic fibrosis severity ( 21602797) Gamma glutamyl transferase levels ( 29403010 33339817) Lung disease severity in cystic fibrosis ( 26417704) Prostate-specific antigen levels ( 28139693) Systemic lupus erythematosus ( 19838195)	Triptolide cytotoxicity ( 26121980)
Interacting Genes		18 interacting genes: APAF1 BAZ2B CFAP206 GORASP2 IMPDH2 LNX1 NIF3L1 NTAQ1 NUDT18 PDZD4 PPP1CC PSMA1 SDCBP SKP1 TNPO2 VIM VPS25 ZBTB25	93 interacting genes: ALKBH4 AP5B1 APIP ARPIN BDKRB2 BEND7 C14orf119 CASP7 CCDC102B CCDC85B CDKN2B CDKN2C CDKN2D COIL COPS2 CUTC CYRIB DCDC2 DCTD DCTPP1 DHPS DMC1 DMRTB1 DTX2 DUSP23 DUSP29 DYNLT3 EIF4A3 EIF5A2 ENOX1 EPHB6 FLAD1 FXR2 GNMT GRB2 IP6K3 KCNIP1 KCTD17 KCTD7 KCTD9 KRT15 KXD1 LAMTOR3 LMO2 LMO3 MAGEA11 MAPRE2 MLXIPL NATD1 NEK6 NGB NME1 NME7 NOL3 NUDT14 NUDT21 ORC5 PAFAH1B3 PAICS PCBD1 PNMA1 POLR1C PPIH PRTFDC1 PTPA RABAC1 RAD54B RPIA S100A1 SAT1 SEPTIN1 SNF8 SPG21 SSX2IP STAT3 STK16 SULT1A2 SULT1A3 SULT2A1 SYT17 TCL1A THOC7 TIFA TRAF2 TRIM21 TRIM27 TRIP13 TSC22D4 TXN VIM YES1 YWHAQ ZBED1
Entrez ID		51074	60491
HPRD ID		14725	10424
Ensembl ID		ENSG00000149089	ENSG00000196290
Uniprot IDs		Q96GX9	Q9GZT8
PDB IDs		4M6R
Enriched GO Terms of Interacting Partners?			Identical Protein Binding Cytoplasm Protein Binding Cytosol Protein Complex Oligomerization Nucleotide Metabolic Process Nucleobase-containing Small Molecule Metabolic Process Ethanol Catabolic Process Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity 3'-phosphoadenosine 5'-phosphosulfate Metabolic Process Ethanol Metabolic Process Nucleoside Phosphate Metabolic Process Phosphate-containing Compound Metabolic Process Sulfation Pyrimidine Nucleotide Metabolic Process Polyamine Catabolic Process Nucleus Ribose Phosphate Metabolic Process Reciprocal Meiotic Recombination
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