APIP and PDZD4

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		APIP	PDZD4
Gene Name		APAF1 interacting protein	PDZ domain containing 4
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm	Cell Cortex
	Molecular Function	Protein Binding Zinc Ion Binding Identical Protein Binding Methylthioribulose 1-phosphate Dehydratase Activity
	Biological Process	Sulfur Amino Acid Metabolic Process Polyamine Metabolic Process Apoptotic Process L-methionine Biosynthetic Process From S-adenosylmethionine L-methionine Biosynthetic Process From Methylthioadenosine Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Apoptotic Process Small Molecule Metabolic Process Regulation Of ERK1 And ERK2 Cascade
Pathways		Metabolism of polyamines Sulfur amino acid metabolism Methionine salvage pathway Metabolism of amino acids and derivatives
Drugs
Diseases
GWAS		Chronic obstructive pulmonary disease-related biomarkers ( 23144326) Cystic fibrosis severity ( 21602797)
Protein-Protein Interactions		17 interactors: APAF1 C6orf165 IMPDH2 LNX1 NIF3L1 NUDT18 PDZD4 PPP1CC PSMA1 SDCBP SKP1 TNPO2 TSC22D4 VIM VPS25 WDYHV1 ZBTB25	3 interactors: APIP APP GFI1B
Entrez ID		51074	57595
HPRD ID		14725	06601
Ensembl ID		ENSG00000149089	ENSG00000067840
Uniprot IDs		J3KN82 Q96GX9	B3KVR9 B7ZKY3 D3DWW0 Q17RL8 Q76G19
PDB IDs
Enriched GO Terms of Interacting Partners?		Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Catabolic Process Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition GDP Catabolic Process Response To G1 DNA Damage Checkpoint Signaling DGDP Catabolic Process DADP Catabolic Process Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Positive Regulation Of Proteolysis Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process 7,8-dihydroneopterin 3'-triphosphate Biosynthetic Process Regulation Of Ubiquitin-protein Transferase Activity Cellular Macromolecule Catabolic Process Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Protein Targeting To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Dihydrobiopterin Metabolic Process Positive Regulation Of Extracellular Vesicular Exosome Assembly GMP Biosynthetic Process Positive Regulation Of Protein Ubiquitination Regulation Of Extracellular Vesicular Exosome Assembly Purine Ribonucleoside Diphosphate Catabolic Process Endosome Transport Via Multivesicular Body Sorting Pathway Nucleobase-containing Small Molecule Catabolic Process Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Cellular Protein Catabolic Process Late Endosome To Vacuole Transport Viral Process G1/S Transition Of Mitotic Cell Cycle Bergmann Glial Cell Differentiation Ribonucleoside Diphosphate Catabolic Process Regulation Of Metabolic Process Protein Ubiquitination Circadian Rhythm Regulation Of Apoptotic DNA Fragmentation GMP Metabolic Process Nucleoside Diphosphate Catabolic Process Protein Modification By Small Protein Conjugation Positive Regulation Of Exosomal Secretion Regulation Of Exosomal Secretion Deoxyribonucleoside Diphosphate Metabolic Process Regulation Of Protein Ubiquitination Substrate-dependent Cell Migration, Cell Extension Histone H2A Monoubiquitination	Synaptic Growth At Neuromuscular Junction L-methionine Biosynthetic Process From S-adenosylmethionine Collateral Sprouting In Absence Of Injury Collateral Sprouting Axon Midline Choice Point Recognition S-adenosylmethionine Cycle Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Axon Choice Point Recognition L-methionine Biosynthetic Process From Methylthioadenosine Neuron Remodeling L-methionine Salvage Methionine Biosynthetic Process S-adenosylmethionine Metabolic Process Cellular Copper Ion Homeostasis Methionine Metabolic Process Sulfur Amino Acid Biosynthetic Process Copper Ion Homeostasis Suckling Behavior Regulation Of Histone H3-K4 Methylation Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Neuron Maturation MRNA Polyadenylation Regulation Of Epidermal Growth Factor-activated Receptor Activity Polyamine Metabolic Process Mating Behavior Endoplasmic Reticulum Calcium Ion Homeostasis RNA Polyadenylation Neuron Recognition Apoptotic Process Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Programmed Cell Death Sulfur Amino Acid Metabolic Process Ionotropic Glutamate Receptor Signaling Pathway Regulation Of G2/M Transition Of Mitotic Cell Cycle Cell Death Death Regulation Of Cell Cycle G2/M Phase Transition Axon Cargo Transport Mating Neuromuscular Junction Development Regulation Of Histone Methylation Positive Regulation Of Mitotic Cell Cycle Phase Transition Neuron Apoptotic Process Positive Regulation Of Cell Cycle Phase Transition Nucleobase-containing Compound Metabolic Process Regulation Of Protein Tyrosine Kinase Activity Visual Learning Glutamate Receptor Signaling Pathway Visual Behavior Neuron Death
Tagcloud ?		11p12 14q24 6q12 9p24 abcd4 acyp1 amplifications cd109 cd274 commd9 coq6 cttn fjx1 hbld1 interscience jdp2 jpages ltbp2 myo6 otscc pdhx pinpointed ppfia1 q14 rln1 slc1a1 suppmat trim44 znf410
Tagcloud (Difference) ?		11p12 14q24 6q12 9p24 abcd4 acyp1 amplifications cd109 cd274 commd9 coq6 cttn fjx1 hbld1 interscience jdp2 jpages ltbp2 myo6 otscc pdhx pinpointed ppfia1 q14 rln1 slc1a1 suppmat trim44 znf410
Tagcloud (Intersection) ?