APIP and IMPDH2

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		APIP	IMPDH2
Gene Name		APAF1 interacting protein	IMP (inosine 5-monophosphate) dehydrogenase 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm	Nucleus Cytoplasm Peroxisomal Membrane Cytosol Membrane Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Zinc Ion Binding Identical Protein Binding Methylthioribulose 1-phosphate Dehydratase Activity	Nucleotide Binding DNA Binding RNA Binding IMP Dehydrogenase Activity Metal Ion Binding
	Biological Process	Sulfur Amino Acid Metabolic Process Polyamine Metabolic Process Apoptotic Process L-methionine Biosynthetic Process From S-adenosylmethionine L-methionine Biosynthetic Process From Methylthioadenosine Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Apoptotic Process Small Molecule Metabolic Process Regulation Of ERK1 And ERK2 Cascade	Purine Nucleobase Metabolic Process GMP Biosynthetic Process Purine Ribonucleoside Monophosphate Biosynthetic Process Small Molecule Metabolic Process Lymphocyte Proliferation Protein Homotetramerization Nucleobase-containing Small Molecule Metabolic Process Oxidation-reduction Process Retina Development In Camera-type Eye Cellular Response To Interleukin-4
Pathways		Metabolism of polyamines Sulfur amino acid metabolism Methionine salvage pathway Metabolism of amino acids and derivatives	Purine ribonucleoside monophosphate biosynthesis Purine metabolism Metabolism of nucleotides
Drugs			NADH Mycophenolate mofetil Mycophenolic acid Ribavirin Monophosphate Nicotinamide-Adenine-Dinucleotide Selenazole-4-Carboxyamide-Adenine Dinucleotide 6-Chloropurine Riboside, 5\'-Monophosphate Inosinic Acid
Diseases
GWAS		Chronic obstructive pulmonary disease-related biomarkers ( 23144326) Cystic fibrosis severity ( 21602797)
Protein-Protein Interactions		17 interactors: APAF1 C6orf165 IMPDH2 LNX1 NIF3L1 NUDT18 PDZD4 PPP1CC PSMA1 SDCBP SKP1 TNPO2 TSC22D4 VIM VPS25 WDYHV1 ZBTB25	6 interactors: AKT1 APIP PIAS4 RSG1 SUMO4 UBQLN4
Entrez ID		51074	3615
HPRD ID		14725	00895
Ensembl ID		ENSG00000149089	ENSG00000178035
Uniprot IDs		J3KN82 Q96GX9	P12268
PDB IDs			1B3O 1NF7 1NFB
Enriched GO Terms of Interacting Partners?		Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Catabolic Process Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition GDP Catabolic Process Response To G1 DNA Damage Checkpoint Signaling DGDP Catabolic Process DADP Catabolic Process Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Positive Regulation Of Proteolysis Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process 7,8-dihydroneopterin 3'-triphosphate Biosynthetic Process Regulation Of Ubiquitin-protein Transferase Activity Cellular Macromolecule Catabolic Process Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Protein Targeting To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Dihydrobiopterin Metabolic Process Positive Regulation Of Extracellular Vesicular Exosome Assembly GMP Biosynthetic Process Positive Regulation Of Protein Ubiquitination Regulation Of Extracellular Vesicular Exosome Assembly Purine Ribonucleoside Diphosphate Catabolic Process Endosome Transport Via Multivesicular Body Sorting Pathway Nucleobase-containing Small Molecule Catabolic Process Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Cellular Protein Catabolic Process Late Endosome To Vacuole Transport Viral Process G1/S Transition Of Mitotic Cell Cycle Bergmann Glial Cell Differentiation Ribonucleoside Diphosphate Catabolic Process Regulation Of Metabolic Process Protein Ubiquitination Circadian Rhythm Regulation Of Apoptotic DNA Fragmentation GMP Metabolic Process Nucleoside Diphosphate Catabolic Process Protein Modification By Small Protein Conjugation Positive Regulation Of Exosomal Secretion Regulation Of Exosomal Secretion Deoxyribonucleoside Diphosphate Metabolic Process Regulation Of Protein Ubiquitination Substrate-dependent Cell Migration, Cell Extension Histone H2A Monoubiquitination	Protein Sumoylation Glycogen Cell Differentiation Involved In Embryonic Placenta Development Protein Modification By Small Protein Conjugation Positive Regulation Of Keratinocyte Apoptotic Process L-methionine Biosynthetic Process From S-adenosylmethionine Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Plasma Membrane Long-chain Fatty Acid Transport Negative Regulation Of Fatty Acid Beta-oxidation Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Apoptotic Signaling Pathway Peptidyl-amino Acid Modification S-adenosylmethionine Cycle Response To UV-A Activation-induced Cell Death Of T Cells Peptidyl-lysine Modification Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Involved In G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Cellular Response To Granulocyte Macrophage Colony-stimulating Factor Stimulus L-methionine Biosynthetic Process From Methylthioadenosine L-methionine Salvage Negative Regulation Of Fatty Acid Oxidation Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Protein Sumoylation Positive Regulation Of Glycogen Biosynthetic Process Nitric Oxide Biosynthetic Process Regulation Of Protein Catabolic Process Negative Regulation Of Cell Size Regulation Of Apoptotic Process Methionine Biosynthetic Process Spongiotrophoblast Layer Development Negative Regulation Of Release Of Cytochrome C From Mitochondria S-adenosylmethionine Metabolic Process T Cell Apoptotic Process Regulation Of Fatty Acid Beta-oxidation Positive Regulation Of Nitric-oxide Synthase Activity Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Cell Death Methionine Metabolic Process Positive Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Protein Sumoylation Insulin-like Growth Factor Receptor Signaling Pathway Sulfur Amino Acid Biosynthetic Process Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Peripheral Nervous System Myelin Maintenance Response To Food Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Mammary Gland Epithelial Cell Differentiation Negative Regulation Of Fatty Acid Metabolic Process Negative Regulation Of Lipid Transport
Tagcloud ?		11p12 14q24 6q12 9p24 abcd4 acyp1 amplifications cd109 cd274 commd9 coq6 cttn fjx1 hbld1 interscience jdp2 jpages ltbp2 myo6 otscc pdhx pinpointed ppfia1 q14 rln1 slc1a1 suppmat trim44 znf410	biogenesis biosynthesis dehydrogenase deoxy disrupts dually genotoxic gtp guanine inauzhin inosine inz mdm2 monophosphate notion nucleostemin pools ribonucleotide ribosomal rpl11 rpl5 rps rrna rs sirt1 stressor suppresses surprisingly
Tagcloud (Difference) ?		11p12 14q24 6q12 9p24 abcd4 acyp1 amplifications cd109 cd274 commd9 coq6 cttn fjx1 hbld1 interscience jdp2 jpages ltbp2 myo6 otscc pdhx pinpointed ppfia1 q14 rln1 slc1a1 suppmat trim44 znf410	biogenesis biosynthesis dehydrogenase deoxy disrupts dually genotoxic gtp guanine inauzhin inosine inz mdm2 monophosphate notion nucleostemin pools ribonucleotide ribosomal rpl11 rpl5 rps rrna rs sirt1 stressor suppresses surprisingly
Tagcloud (Intersection) ?