VPS36 and TSG101

Number of citations of the paper that reports this interaction (PMID 14505570)
292

Data Source:
HPRD (two hybrid)

		VPS36	TSG101
Gene Name		vacuolar protein sorting 36 homolog (S. cerevisiae)	tumor susceptibility 101
Image
Gene Ontology Annotations	Cellular Component	Nucleus Lysosome Endosome Late Endosome Cytosol Membrane Extracellular Vesicular Exosome	ESCRT I Complex Nucleolus Cytoplasm Early Endosome Late Endosome Multivesicular Body Plasma Membrane Endosome Membrane Late Endosome Membrane Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Phosphatidylinositol-3-phosphate Binding Ubiquitin Binding	DNA Binding Transcription Corepressor Activity Protein Binding Ubiquitin Protein Ligase Binding Protein Homodimerization Activity Ubiquitin Binding Calcium-dependent Protein Binding
	Biological Process	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Protein Transport Endosomal Transport Membrane Organization	Regulation Of Cell Growth Cellular Protein Modification Process Cell Cycle Arrest Negative Regulation Of Cell Proliferation Protein Transport Viral Process Endosomal Transport Viral Life Cycle Virion Assembly Viral Protein Processing Keratinocyte Differentiation Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Negative Regulation Of Transcription, DNA-templated Viral Budding Cell Division Membrane Organization Intracellular Transport Of Virus Positive Regulation Of Exosomal Secretion Regulation Of Extracellular Vesicular Exosome Assembly
Pathways		Endosomal Sorting Complex Required For Transport (ESCRT)	Assembly Of The HIV Virion Synthesis And Processing Of GAG, GAGPOL Polyproteins HIV Life Cycle Budding and maturation of HIV virion HIV Infection Endosomal Sorting Complex Required For Transport (ESCRT) Membrane binding and targetting of GAG proteins Late Phase of HIV Life Cycle
Drugs
Diseases
GWAS
Protein-Protein Interactions		7 interactors: CHMP6 RILP SNF8 SPRY2 TSG101 UBC VPS25	69 interactors: AATF ADRB2 AKAP9 AR ARRDC1 BCR BIRC2 CDKN1A CDS2 CEP55 DAXX DMAP1 DNMT1 DZIP3 EP300 FAM9B GGA1 GGA3 GMCL1 HAUS1 HCK HCRP1 HGS IQGAP1 ITSN1 JUN KIF5A KIFC3 KRT13 KRT15 KRT31 LRSAM1 MDM2 MGRN1 MKRN3 MVB12A NR3C1 PDCD6IP PDLIM7 PPFIBP2 RAD18 RNF111 RNF126 RNF41 ROCK1 SCAMP3 SCNN1A SNF8 SYCE1 TAX1BP1 THRB TNNT3 TOM1L1 TP53 TRAIP TRIM23 TRIM35 TRIM46 TRIM74 UBA52 UBAP1 USHBP1 VPS11 VPS28 VPS36 VPS37A VPS37B VPS37C VPS37D
Entrez ID		51028	7251
HPRD ID		12620	03229
Ensembl ID		ENSG00000136100	ENSG00000074319
Uniprot IDs		Q86VN1	Q99816
PDB IDs		2HTH 2ZME 3CUQ	1KPP 1KPQ 1M4P 1M4Q 1S1Q 2F0R 3IV1 3OBQ 3OBS 3OBU 3OBX 3P9G 3P9H 4EJE
Enriched GO Terms of Interacting Partners?		Endosomal Transport Vacuolar Transport Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Establishment Of Localization In Cell Cellular Localization Protein Targeting To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Intracellular Transport Endosome Transport Via Multivesicular Body Sorting Pathway Membrane Organization Late Endosome To Vacuole Transport Positive Regulation Of Exosomal Secretion Regulation Of Exosomal Secretion Viral Protein Processing Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Transport Protein Catabolic Process Viral Life Cycle Establishment Of Protein Localization Protein Targeting To Vacuole Virion Assembly Establishment Of Protein Localization To Vacuole Intracellular Transport Of Virus Cellular Macromolecule Catabolic Process Protein Localization Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Establishment Of Protein Localization To Organelle Cell Cycle Process Positive Regulation Of Exocytosis Protein Targeting Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Negative Regulation Of Cardiac Muscle Cell Myoblast Differentiation Cell Cycle Protein Localization To Organelle Viral Process Negative Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Transport Proteolysis Positive Regulation Of Protein Ubiquitination Mitotic Cell Cycle Process Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Cytoplasmic Transport Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Cellular Protein Catabolic Process	Virion Assembly Viral Protein Processing Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Endosomal Transport Establishment Of Protein Localization Intracellular Transport Of Virus Viral Process Protein Transport Protein Localization Protein Catabolic Process Intracellular Transport Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Establishment Of Localization In Cell Viral Life Cycle Protein Ubiquitination Apoptotic Process Cellular Localization Protein Modification By Small Protein Conjugation Programmed Cell Death Ubiquitin-dependent Protein Catabolic Process Cell Death Enzyme Linked Receptor Protein Signaling Pathway Modification-dependent Protein Catabolic Process Death Protein Polyubiquitination Cellular Macromolecule Catabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Membrane Organization Apoptotic Signaling Pathway Transport Positive Regulation Of Metabolic Process Cellular Response To Organic Substance Response To Organic Substance Regulation Of Protein Metabolic Process Vacuolar Transport Positive Regulation Of Protein Metabolic Process Positive Regulation Of Exosomal Secretion Regulation Of Exosomal Secretion Negative Regulation Of Apoptotic Process Protein Processing Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Cellular Protein Metabolic Process Regulation Of Cell Cycle Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Cell Death Regulation Of Cell Death Response To Lipid Signal Transduction By P53 Class Mediator
Tagcloud ?		bicoid budding complementation eap20 eap30 eap45 endosomal escrt escrtii evolutionarily exemplifies fertilised implication inward juxtanuclear localisation opts orthologue outwards rab7 staufen staufen1 tedly topologically trafficking tri unexpec vesicular vps22	000xg calreticulin cd81 centrifugation cleared contaminating devoid dulbecco eagle exosomal exosome exosomes fill fl3 hek293 impacted microsomes nanoparticle nta overnight pelleted phenol purity sedimentation speeds syntenin ultracentrifugation vdac1 vesicle
Tagcloud (Difference) ?		bicoid budding complementation eap20 eap30 eap45 endosomal escrt escrtii evolutionarily exemplifies fertilised implication inward juxtanuclear localisation opts orthologue outwards rab7 staufen staufen1 tedly topologically trafficking tri unexpec vesicular vps22	000xg calreticulin cd81 centrifugation cleared contaminating devoid dulbecco eagle exosomal exosome exosomes fill fl3 hek293 impacted microsomes nanoparticle nta overnight pelleted phenol purity sedimentation speeds syntenin ultracentrifugation vdac1 vesicle
Tagcloud (Intersection) ?