VPS36 and SNF8

Number of citations of the paper that reports this interaction (PMID 14505570)
292

Data Source:
BioGRID (two hybrid, two hybrid, affinity chromatography technology)
HPRD (in vivo)

		VPS36	SNF8
Gene Name		vacuolar protein sorting 36 homolog (S. cerevisiae)	SNF8, ESCRT-II complex subunit
Image
Gene Ontology Annotations	Cellular Component	Nucleus Lysosome Endosome Late Endosome Cytosol Membrane Extracellular Vesicular Exosome	ESCRT II Complex Nucleoplasm Transcription Factor Complex Cytoplasm Cytosol Late Endosome Membrane Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Phosphatidylinositol-3-phosphate Binding Ubiquitin Binding	Protein Binding Transcription Factor Binding Protein Homodimerization Activity
	Biological Process	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Protein Transport Endosomal Transport Membrane Organization	Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Endosomal Transport Protein Targeting To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Membrane Organization Positive Regulation Of Exosomal Secretion
Pathways		Endosomal Sorting Complex Required For Transport (ESCRT)	Endosomal Sorting Complex Required For Transport (ESCRT)
Drugs
Diseases
GWAS			Coronary heart disease ( 21378990)
Protein-Protein Interactions		7 interactors: CHMP6 RILP SNF8 SPRY2 TSG101 UBC VPS25	15 interactors: ADORA1 CHMP6 DVL2 ELL GOLGA2 KDM1A NIF3L1 PRMT6 RILP SUV39H2 TRIM54 TSG101 VAC14 VPS25 VPS36
Entrez ID		51028	11267
HPRD ID		12620	16847
Ensembl ID		ENSG00000136100
Uniprot IDs		Q86VN1	Q96H20
PDB IDs		2HTH 2ZME 3CUQ	2ZME 3CUQ
Enriched GO Terms of Interacting Partners?		Endosomal Transport Vacuolar Transport Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Establishment Of Localization In Cell Cellular Localization Protein Targeting To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Intracellular Transport Endosome Transport Via Multivesicular Body Sorting Pathway Membrane Organization Late Endosome To Vacuole Transport Positive Regulation Of Exosomal Secretion Regulation Of Exosomal Secretion Viral Protein Processing Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Transport Protein Catabolic Process Viral Life Cycle Establishment Of Protein Localization Protein Targeting To Vacuole Virion Assembly Establishment Of Protein Localization To Vacuole Intracellular Transport Of Virus Cellular Macromolecule Catabolic Process Protein Localization Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Establishment Of Protein Localization To Organelle Cell Cycle Process Positive Regulation Of Exocytosis Protein Targeting Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Negative Regulation Of Cardiac Muscle Cell Myoblast Differentiation Cell Cycle Protein Localization To Organelle Viral Process Negative Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Transport Proteolysis Positive Regulation Of Protein Ubiquitination Mitotic Cell Cycle Process Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Cytoplasmic Transport Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Cellular Protein Catabolic Process	Endosomal Transport Vacuolar Transport Viral Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Negative Regulation Of Circadian Rhythm Protein Localization Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Membrane Organization Protein Transport Regulation Of Gene Expression Regulation Of Metabolic Process Establishment Of Protein Localization Intracellular Transport Transcription, DNA-templated Positive Regulation Of Protein Tyrosine Kinase Activity RNA Biosynthetic Process Cellular Localization Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Gene Expression Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Protein Binding Negative Regulation Of Long Term Synaptic Depression Negative Regulation Of Neurotrophin Production Positive Regulation Of Nucleoside Transport Regulation Of Primitive Erythrocyte Differentiation Negative Regulation Of Cardiac Muscle Cell Myoblast Differentiation Regulation Of Protein Tyrosine Kinase Activity Biosynthetic Process Establishment Of Localization In Cell Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Chordate Embryonic Development Embryo Development Ending In Birth Or Egg Hatching Histone H3-R2 Methylation Negative Regulation Of Mucus Secretion 7,8-dihydroneopterin 3'-triphosphate Biosynthetic Process Negative Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Regulation Of Circadian Rhythm Histone Modification Negative Regulation Of Binding RNA Metabolic Process Convergent Extension Involved In Neural Plate Elongation Regulation Of Long Term Synaptic Depression Protein Targeting To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway
Tagcloud ?		bicoid budding complementation eap20 eap30 eap45 endosomal escrt escrtii evolutionarily exemplifies fertilised implication inward juxtanuclear localisation opts orthologue outwards rab7 staufen staufen1 tedly topologically trafficking tri unexpec vesicular vps22	cerevisiae cloning complementation dalton derepression diploids distinguished extremely homozygous impair invertase limitation notably predicts raffinose saccharomyces sick snf1 snf2 snf4 snf5 snf6 snf7 sporulation spt6 ssn20 ssn6 suc2 suppressors
Tagcloud (Difference) ?		bicoid budding eap20 eap30 eap45 endosomal escrt escrtii evolutionarily exemplifies fertilised implication inward juxtanuclear localisation opts orthologue outwards rab7 staufen staufen1 tedly topologically trafficking tri unexpec vesicular vps22	cerevisiae cloning dalton derepression diploids distinguished extremely homozygous impair invertase limitation notably predicts raffinose saccharomyces sick snf1 snf2 snf4 snf5 snf6 snf7 sporulation spt6 ssn20 ssn6 suc2 suppressors
Tagcloud (Intersection) ?		complementation