VPS36 and VPS25

Number of citations of the paper that reports this interaction (PMID 16371348)
43

Data Source:
HPRD (in vivo, two hybrid)

		VPS36	VPS25
Gene Name		vacuolar protein sorting 36 homolog (S. cerevisiae)	vacuolar protein sorting 25 homolog (S. cerevisiae)
Image
Gene Ontology Annotations	Cellular Component	Nucleus Lysosome Endosome Late Endosome Cytosol Membrane Extracellular Vesicular Exosome	ESCRT II Complex Nucleus Nucleoplasm Nucleolus Mitochondrion Cytosol Endosome Membrane Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Phosphatidylinositol-3-phosphate Binding Ubiquitin Binding	Structural Molecule Activity Protein Binding Protein Homodimerization Activity
	Biological Process	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Protein Transport Endosomal Transport Membrane Organization	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Endosomal Transport Protein Targeting To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Membrane Organization
Pathways		Endosomal Sorting Complex Required For Transport (ESCRT)	Endosomal Sorting Complex Required For Transport (ESCRT)
Drugs
Diseases
GWAS
Protein-Protein Interactions		7 interactors: CHMP6 RILP SNF8 SPRY2 TSG101 UBC VPS25	10 interactors: APIP BEND5 CHMP6 CRLF3 REL RHOXF2 SNF8 SPRY2 TRIM27 VPS36
Entrez ID		51028	84313
HPRD ID		12620	14396
Ensembl ID		ENSG00000136100	ENSG00000131475
Uniprot IDs		Q86VN1	Q9BRG1
PDB IDs		2HTH 2ZME 3CUQ	2ZME 3CUQ 3HTU
Enriched GO Terms of Interacting Partners?		Endosomal Transport Vacuolar Transport Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Establishment Of Localization In Cell Cellular Localization Protein Targeting To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Intracellular Transport Endosome Transport Via Multivesicular Body Sorting Pathway Membrane Organization Late Endosome To Vacuole Transport Positive Regulation Of Exosomal Secretion Regulation Of Exosomal Secretion Viral Protein Processing Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Transport Protein Catabolic Process Viral Life Cycle Establishment Of Protein Localization Protein Targeting To Vacuole Virion Assembly Establishment Of Protein Localization To Vacuole Intracellular Transport Of Virus Cellular Macromolecule Catabolic Process Protein Localization Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Establishment Of Protein Localization To Organelle Cell Cycle Process Positive Regulation Of Exocytosis Protein Targeting Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Negative Regulation Of Cardiac Muscle Cell Myoblast Differentiation Cell Cycle Protein Localization To Organelle Viral Process Negative Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Transport Proteolysis Positive Regulation Of Protein Ubiquitination Mitotic Cell Cycle Process Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Cytoplasmic Transport Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Cellular Protein Catabolic Process	Endosomal Transport Vacuolar Transport Regulation Of Gene Expression Establishment Of Localization In Cell Regulation Of Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Interleukin-2 Secretion L-methionine Biosynthetic Process From S-adenosylmethionine Cellular Localization Protein Targeting To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Cytokine Production Protein Transport Establishment Of Protein Localization Intracellular Transport Mitotic Cell Cycle Process Regulation Of Transcription, DNA-templated S-adenosylmethionine Cycle Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Negative Regulation Of Calcium Ion Import Endosome Transport Via Multivesicular Body Sorting Pathway Mitotic Cell Cycle Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Neurotrophin TRK Receptor Signaling Pathway Late Endosome To Vacuole Transport Regulation Of Intracellular Signal Transduction Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of Protein Kinase Activity Lung Growth Interferon-gamma Secretion L-methionine Biosynthetic Process From Methylthioadenosine Regulation Of Transcription From RNA Polymerase II Promoter Membrane Organization Negative Regulation Of Kinase Activity Regulation Of Neurotrophin TRK Receptor Signaling Pathway Protein Localization L-methionine Salvage Positive Regulation Of Exosomal Secretion Regulation Of Exosomal Secretion Positive Regulation Of Interleukin-12 Biosynthetic Process Bud Elongation Involved In Lung Branching Negative Regulation Of Cell Death Negative Regulation Of Transferase Activity Cell Cycle Process Negative Regulation Of Viral Release From Host Cell Negative Regulation Of Protein Phosphorylation Establishment Of Organelle Localization Methionine Biosynthetic Process Regulation Of Interleukin-12 Biosynthetic Process
Tagcloud ?		bicoid budding complementation eap20 eap30 eap45 endosomal escrt escrtii evolutionarily exemplifies fertilised implication inward juxtanuclear localisation opts orthologue outwards rab7 staufen staufen1 tedly topologically trafficking tri unexpec vesicular vps22	bmp consequent contexts directs endosomal endosome enu escrt fgf fgfr gestation hyperactivation hypomorphic limbs machineries mutagenesis mysterious patterning polydactylous polydactyly preferential shh sort sorting specification survive unperturbed vacuolar vertebrate
Tagcloud (Difference) ?		bicoid budding complementation eap20 eap30 eap45 escrtii evolutionarily exemplifies fertilised implication inward juxtanuclear localisation opts orthologue outwards rab7 staufen staufen1 tedly topologically trafficking tri unexpec vesicular vps22	bmp consequent contexts directs endosome enu fgf fgfr gestation hyperactivation hypomorphic limbs machineries mutagenesis mysterious patterning polydactylous polydactyly preferential shh sort sorting specification survive unperturbed vacuolar vertebrate
Tagcloud (Intersection) ?		endosomal escrt