LAMA4 and UBR1

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		LAMA4	UBR1
Gene Name		laminin, alpha 4	ubiquitin protein ligase E3 component n-recognin 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Basement Membrane Basal Lamina Laminin-1 Complex Extracellular Matrix Extracellular Vesicular Exosome	Ubiquitin Ligase Complex Proteasome Complex Cytosol
	Molecular Function	Receptor Binding Extracellular Matrix Structural Constituent Protein Binding	Ubiquitin-protein Transferase Activity Zinc Ion Binding Ligase Activity Leucine Binding
	Biological Process	Cell Adhesion Regulation Of Cell Adhesion Extracellular Matrix Organization Regulation Of Cell Migration Regulation Of Embryonic Development	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Negative Regulation Of TOR Signaling Cellular Response To Leucine
Pathways		Laminin interactions ECM proteoglycans Non-integrin membrane-ECM interactions	Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		15 interactors: APC ATF7IP BRD7 COPS6 EEF1A1 GAPDH LRIF1 MED31 PTN RTN4 TP53 TUBB2A UBR1 UNC119 ZHX1	26 interactors: ANXA3 ARL15 ARL3 ARL4D BCL2L1 BTBD2 CDC42 CDC6 DLEU1 DNAJB11 FOS FTH1 GADD45A GSK3B LAMA4 LAMTOR3 NDUFA4L2 NUDT3 PTPRS SERPINB9 SPRY2 TAC3 TP53I3 UBC UBE2A UBE2B
Entrez ID		3910	197131
HPRD ID		02532	09342
Ensembl ID		ENSG00000112769	ENSG00000159459
Uniprot IDs		Q16363 Q5D044	Q8IWV7
PDB IDs			3NY1
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Fibroblast Proliferation Transcription, DNA-templated Regulation Of Chromosome Organization Mitotic Cytokinesis RNA Biosynthetic Process Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Phase Transition Neuron Apoptotic Process Negative Regulation Of Cell Proliferation Negative Regulation Of Clathrin-mediated Endocytosis Peptidyl-cysteine S-trans-nitrosylation Regulation Of Cellular Component Organization Neuron Death T Cell Differentiation In Thymus Positive Regulation Of Histone Modification Negative Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Metabolic Process Regulation Of Protein Complex Assembly Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Macromitophagy Cellular Response To Leucine Negative Regulation Of Caveolin-mediated Endocytosis Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Apoptotic Process Oligodendrocyte Apoptotic Process Regulation Of Cell Proliferation Regulation Of Fibroblast Proliferation Regulation Of Cellular Amino Acid Metabolic Process Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle RNA Metabolic Process Positive Regulation Of Organelle Organization Regulation Of Branching Morphogenesis Of A Nerve Cytokinesis, Completion Of Separation Negative Regulation Of Helicase Activity Cytokinesis Regulation Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle Apoptotic Process Negative Regulation Of Odontogenesis Regulation Of Histone Modification Gene Expression Positive Regulation Of Cell Division Programmed Cell Death Peptidyl-cysteine S-nitrosylation Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle Process Protein Complex Assembly	Response To Stimulus Cell Cycle Process Regulation Of Protein Kinase Activity Regulation Of Protein Phosphorylation Cellular Localization Cellular Response To Stimulus Regulation Of Kinase Activity Establishment Of Localization In Cell Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Immune Response Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Phosphorylation ERBB Signaling Pathway Cell Cycle Signaling Intracellular Signal Transduction Regulation Of Catalytic Activity Cellular Response To Organic Substance Cell Communication Regulation Of Cellular Process Regulation Of Apoptotic Process Regulation Of Phosphorus Metabolic Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Phosphorylation Response To Abiotic Stimulus Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Cellular Response To Stress Response To Radiation Positive Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Cell Cycle Process Regulation Of Cell Death Signal Transduction Regulation Of ERBB Signaling Pathway Negative Regulation Of Catalytic Activity Positive Regulation Of Kinase Activity Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of Cellular Protein Metabolic Process Immune System Process Histone H2A Ubiquitination Canonical Wnt Signaling Pathway Regulation Of Protein Metabolic Process Fc Receptor Signaling Pathway Positive Regulation Of Phosphorylation Positive Regulation Of Signal Transduction Regulation Of Peptidyl-serine Phosphorylation Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Cycle Negative Regulation Of Protein Metabolic Process Positive Regulation Of Transferase Activity
Tagcloud ?		angpt1 angpt2 ca9 cdh5 cdkn2a ednra erbb1 gadd45b glut1 hif2a hippel inherited irs1 lindau looked microadenomas neuroendocrine nineteen ocln pannet pdgfb predisposing rps6kb1 vegfa vegfr1 vegfr2 vhl vim von	26s abruptly adducts anchoring breakdown conjugation e1 e3 e3s f1 fluctuate fos harbors heterodimeric homodimer intermediates lived multiply pathophysiological presumably reconstituted stabilizes sulfhydryl thermolabile thioester ts20 ubch5 ubiquitin ubiquitinated
Tagcloud (Difference) ?		angpt1 angpt2 ca9 cdh5 cdkn2a ednra erbb1 gadd45b glut1 hif2a hippel inherited irs1 lindau looked microadenomas neuroendocrine nineteen ocln pannet pdgfb predisposing rps6kb1 vegfa vegfr1 vegfr2 vhl vim von	26s abruptly adducts anchoring breakdown conjugation e1 e3 e3s f1 fluctuate fos harbors heterodimeric homodimer intermediates lived multiply pathophysiological presumably reconstituted stabilizes sulfhydryl thermolabile thioester ts20 ubch5 ubiquitin ubiquitinated
Tagcloud (Intersection) ?