LAMA4 and UBR1

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		LAMA4	UBR1
Description		laminin subunit alpha 4	ubiquitin protein ligase E3 component n-recognin 1
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Basement Membrane Extracellular Matrix Extracellular Exosome	Ubiquitin Ligase Complex Proteasome Complex Cytoplasm Cytosol
	Molecular Function	Signaling Receptor Binding Extracellular Matrix Structural Constituent Protein Binding	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity L-leucine Binding
	Biological Process	Cell Adhesion Regulation Of Cell Adhesion Regulation Of Cell Migration Regulation Of Embryonic Development Negative Regulation Of Cold-induced Thermogenesis	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Protein Catabolic Process Negative Regulation Of TOR Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Cellular Response To L-leucine Ubiquitin-dependent Protein Catabolic Process Via The N-end Rule Pathway
Pathways		Laminin interactions Laminin interactions Non-integrin membrane-ECM interactions ECM proteoglycans MET activates PTK2 signaling Attachment of bacteria to epithelial cells Formation of the dystrophin-glycoprotein complex (DGC) Formation of the dystrophin-glycoprotein complex (DGC) Developmental Lineage of Pancreatic Ductal Cells	Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases			Johanson-Blizzard syndrome
GWAS		A body shape index ( 34021172) Bipolar disorder ( 31043756) Metabolite levels ( 23823483) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Appendicular lean mass ( 33097823) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) MGMT methylation in smokers ( 26183928) Triglycerides ( 25961943)
Interacting Genes		17 interacting genes: APC ATF7IP BRD7 COPS6 EEF1A1 FHL1 GAPDH LRIF1 MED31 PTN RTN4 RTP2 TP53 TUBB2A UBR1 UNC119 ZHX1	33 interacting genes: ANXA3 ARL15 ARL3 ARL4D ATF3 BCL2L1 BTBD2 CDC42 CDC6 COXFA4L2 DLEU1 DNAJB11 FOS FTH1 GADD45A GSK3B LAMA4 LAMTOR3 NR3C1 NTAN1 NTAQ1 NUDT3 PKNOX1 PLIN2 PTPRS RGS4 SERPINB9 SPRY2 TAC3 TP53I3 UBE2A UBE2B UBE2D2
Entrez ID		3910	197131
HPRD ID		02532	09342
Ensembl ID		ENSG00000112769	ENSG00000159459
Uniprot IDs		A0A0A0MTC7 Q16363 Q5D044	Q8IWV7
PDB IDs			3NY1 5TDC
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Epigenetic Regulation Of Gene Expression Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G1/S Phase Transition Positive Regulation Of Hepatocyte Proliferation Negative Regulation Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle Phase Transition Regulation Of Protein Metabolic Process Regulation Of Hepatocyte Proliferation Negative Regulation Of Neuroblast Proliferation Regulation Of Gliogenesis Leukocyte Migration Involved In Inflammatory Response Negative Regulation Of Cell Cycle Process Positive Regulation Of Oligodendrocyte Differentiation Regulation Of Primary Metabolic Process Disordered Domain Specific Binding Negative Regulation Of Neural Precursor Cell Proliferation Molecular Function Activator Activity Nuclear Matrix Negative Regulation Of Neurogenesis Regulation Of Mitotic Cell Cycle Phase Transition Heterochromatin Formation Negative Regulation Of Nervous System Development Negative Regulation Of Cell Cycle Chromatin Remodeling Regulation Of Neurogenesis Negative Regulation Of Fibroblast Proliferation Negative Regulation Of Catalytic Activity Negative Regulation Of Cellular Component Organization Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Cell Growth Negative Regulation Of Gene Expression, Epigenetic Positive Regulation Of Glial Cell Differentiation Regulation Of Oligodendrocyte Differentiation Positive Regulation Of Male Mating Behavior Dendrite Development Regulation Of Neuroblast Proliferation Negative Regulation Of Helicase Activity Negative Regulation Of G1 To G0 Transition Negative Regulation Of Vasculogenesis Positive Regulation Of ERBB3 Signaling Pathway Cell Adhesion Involved In Sprouting Angiogenesis Regulation Of Macromolecule Metabolic Process Regulation Of Nervous System Development Regulation Of Cell Cycle Phase Transition Negative Regulation Of Metabolic Process Transcription Initiation-coupled Chromatin Remodeling Positive Regulation Of Gene Expression, Epigenetic	Protein-N-terminal Asparagine Amidohydrolase Activity HULC Complex Ubiquitin Conjugating Enzyme Activity Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
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