LAMA4 and APC

Number of citations of the paper that reports this interaction (PMID 20936779)
48

Data Source:
BioGRID (two hybrid)

		LAMA4	APC
Gene Name		laminin, alpha 4	adenomatous polyposis coli
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Basement Membrane Basal Lamina Laminin-1 Complex Extracellular Matrix Extracellular Vesicular Exosome	Kinetochore Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Cytoplasmic Microtubule Plasma Membrane Cell-cell Adherens Junction Tight Junction Lateral Plasma Membrane Lamellipodium Beta-catenin Destruction Complex Ruffle Membrane Microtubule Plus-end Axonal Growth Cone
	Molecular Function	Receptor Binding Extracellular Matrix Structural Constituent Protein Binding	Protein Binding Beta-catenin Binding Microtubule Binding Protein Kinase Regulator Activity Protein Kinase Binding Gamma-catenin Binding Cadherin Binding Microtubule Plus-end Binding
	Biological Process	Cell Adhesion Regulation Of Cell Adhesion Extracellular Matrix Organization Regulation Of Cell Migration Regulation Of Embryonic Development	Mitotic Cytokinesis Kidney Development Hair Follicle Development Protein Complex Assembly Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Cellular Response To DNA Damage Stimulus Negative Regulation Of Microtubule Depolymerization Cell Cycle Arrest Metaphase/anaphase Transition Of Mitotic Cell Cycle Mitotic Spindle Assembly Checkpoint Cell Adhesion Axonogenesis Negative Regulation Of Cell Proliferation Axis Specification Anterior/posterior Pattern Specification Dorsal/ventral Pattern Formation Proximal/distal Pattern Formation Cell Migration Positive Regulation Of Cell Migration Positive Regulation Of Epithelial Cell Differentiation Positive Regulation Of Microtubule Polymerization Cytoplasmic Microtubule Organization Positive Regulation Of Pseudopodium Assembly Regulation Of Microtubule-based Process T Cell Differentiation In Thymus Somatic Stem Cell Maintenance Negative Regulation Of Odontogenesis Positive Regulation Of Apoptotic Process Negative Regulation Of MAPK Cascade Canonical Wnt Signaling Pathway Involved In Negative Regulation Of Apoptotic Process Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Apoptotic Process Regulation Of Osteoblast Differentiation Regulation Of Osteoclast Differentiation Positive Regulation Of Protein Catabolic Process Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Cell Adhesion Muscle Cell Cellular Homeostasis Thymus Development Regulation Of Nitrogen Compound Metabolic Process Chromosome Organization Positive Regulation Of Cell Division Regulation Of Attachment Of Spindle Microtubules To Kinetochore Retina Development In Camera-type Eye Canonical Wnt Signaling Pathway Negative Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Tight Junction Assembly Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway
Pathways		Laminin interactions ECM proteoglycans Non-integrin membrane-ECM interactions	misspliced GSK3beta mutants stabilize beta-catenin APC truncation mutants have impaired AXIN binding T41 mutants of beta-catenin aren't phosphorylated truncated APC mutants destabilize the destruction complex TCF7L2 mutants don't bind CTBP Signaling by Wnt deactivation of the beta-catenin transactivating complex APC truncation mutants are not K63 polyubiquitinated disassembly of the destruction complex and recruitment of AXIN to the membrane S37 mutants of beta-catenin aren't phosphorylated Degradation of beta-catenin by the destruction complex RNF mutants show enhanced WNT signaling and proliferation AXIN mutants destabilize the destruction complex, activating WNT signaling S33 mutants of beta-catenin aren't phosphorylated XAV939 inhibits tankyrase, stabilizing AXIN Programmed Cell Death Beta-catenin phosphorylation cascade truncations of AMER1 destabilize the destruction complex Apoptotic cleavage of cellular proteins misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling Apoptotic execution phase phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex AXIN missense mutants destabilize the destruction complex S45 mutants of beta-catenin aren't phosphorylated deletions in the AMER1 gene destabilize the destruction complex TCF dependent signaling in response to WNT AMER1 mutants destabilize the destruction complex deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling Signaling by WNT in cancer
Drugs
Diseases
GWAS
Protein-Protein Interactions		15 interactors: APC ATF7IP BRD7 COPS6 EEF1A1 GAPDH LRIF1 MED31 PTN RTN4 TP53 TUBB2A UBR1 UNC119 ZHX1	109 interactors: ACTN1 AGFG1 ANKRD17 ANXA7 AP2B1 ARHGEF4 AXIN1 AXIN2 BUB1 BUB1B C4A CGNL1 COG4 COG5 CREBBP CSNK1A1 CSNK1E CSNK2A1 CTBP1 CTNNA1 CTNNB1 CYTH2 DLG3 DLGAP1 DST EPAS1 ERBB2IP EXPH5 FAM214A FBXO30 FHOD1 FLNA GIGYF2 GOLGA2 GSK3B HGS HNRNPM HSPA5 HTRA2 ING5 IQGAP1 JUP KIAA1328 KIF5B KIFAP3 KRT13 KRT14 KRT15 KRT17 KRT19 KRT23 KRT5 LAMA3 LAMA4 LPHN1 MACF1 MAPRE1 MAPRE2 MBD5 MCM3AP MUC1 MYH10 MYH11 MYO6 NAV1 NAV2 NAV3 NCKAP5 NCKAP5L ND4 NEB NOSTRIN NUP153 NUP214 NUP54 NUP98 NUPL1 NUPL2 PNISR POM121 POM121C PPP1R13B PPP2CA PPP2R5A PRKACA PSMD1 PTPN13 RANBP9 RBM4B RP1 RPS27 SCRIB SEC31A SETDB1 SIAH1 SMC3 SNRNP200 SPECC1L SPTBN1 SPTBN2 SYNE1 TAF1 TFAP2A TPR TRIM21 TUBA4A XPO1 YWHAQ ZNF106
Entrez ID		3910	324
HPRD ID		02532	01439
Ensembl ID		ENSG00000112769	ENSG00000134982
Uniprot IDs		Q16363 Q5D044	B7Z2B6 P25054 Q4LE70
PDB IDs			1DEB 1EMU 1JPP 1M5I 1T08 1TH1 1V18 2RQU 3AU3 3NMW 3NMX 3NMZ 3QHE 3RL7 3RL8 3T7U 4G69
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Fibroblast Proliferation Transcription, DNA-templated Regulation Of Chromosome Organization Mitotic Cytokinesis RNA Biosynthetic Process Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Phase Transition Neuron Apoptotic Process Negative Regulation Of Cell Proliferation Negative Regulation Of Clathrin-mediated Endocytosis Peptidyl-cysteine S-trans-nitrosylation Regulation Of Cellular Component Organization Neuron Death T Cell Differentiation In Thymus Positive Regulation Of Histone Modification Negative Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Metabolic Process Regulation Of Protein Complex Assembly Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Macromitophagy Cellular Response To Leucine Negative Regulation Of Caveolin-mediated Endocytosis Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Apoptotic Process Oligodendrocyte Apoptotic Process Regulation Of Cell Proliferation Regulation Of Fibroblast Proliferation Regulation Of Cellular Amino Acid Metabolic Process Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle RNA Metabolic Process Positive Regulation Of Organelle Organization Regulation Of Branching Morphogenesis Of A Nerve Cytokinesis, Completion Of Separation Negative Regulation Of Helicase Activity Cytokinesis Regulation Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle Apoptotic Process Negative Regulation Of Odontogenesis Regulation Of Histone Modification Gene Expression Positive Regulation Of Cell Division Programmed Cell Death Peptidyl-cysteine S-nitrosylation Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle Process Protein Complex Assembly	Cell Cycle Mitotic Cell Cycle Organelle Organization Mitotic Cell Cycle Process Protein Localization Cell Cycle Process Cellular Localization Mitotic Nuclear Envelope Disassembly Cellular Protein Localization Establishment Of Localization In Cell MRNA Transport Nuclear Envelope Disassembly Nucleus Organization Nuclear Envelope Organization Endomembrane System Organization RNA Transport Membrane Organization Viral Process RNA Localization Cellular Component Assembly Nucleocytoplasmic Transport Nuclear Transport Response To Stimulus Signaling Intracellular Transport Cell Communication Signal Transduction Regulation Of Cellular Component Organization Establishment Of Protein Localization Cytoplasmic Transport Anatomical Structure Development Cytoskeleton Organization Regulation Of Cell Cycle Viral Transcription Cell Differentiation Regulation Of Glucose Transport Protein Transport Developmental Process Viral Life Cycle Regulation Of Protein Catabolic Process Glucose Transport Cell Development Positive Regulation Of Wnt Signaling Pathway Hexose Transport Cellular Response To Stimulus Protein Localization To Organelle Negative Regulation Of Cell Cycle Regulation Of Signal Transduction Regulation Of Cellular Process Cell Junction Assembly
Tagcloud ?		angpt1 angpt2 ca9 cdh5 cdkn2a ednra erbb1 gadd45b glut1 hif2a hippel inherited irs1 lindau looked microadenomas neuroendocrine nineteen ocln pannet pdgfb predisposing rps6kb1 vegfa vegfr1 vegfr2 vhl vim von	12q 12q21 14q31 15q25 16q23 18p 19q13 20p12 20pq 20q12 21q21 3p14 4pq 5p14 5q14 6p12 7p12 8q23 cardia cdkn2 fist gej mlvi2 mts1 nrasl3 parentheses ptpn1 rca1 xpq xq25
Tagcloud (Difference) ?		angpt1 angpt2 ca9 cdh5 cdkn2a ednra erbb1 gadd45b glut1 hif2a hippel inherited irs1 lindau looked microadenomas neuroendocrine nineteen ocln pannet pdgfb predisposing rps6kb1 vegfa vegfr1 vegfr2 vhl vim von	12q 12q21 14q31 15q25 16q23 18p 19q13 20p12 20pq 20q12 21q21 3p14 4pq 5p14 5q14 6p12 7p12 8q23 cardia cdkn2 fist gej mlvi2 mts1 nrasl3 parentheses ptpn1 rca1 xpq xq25
Tagcloud (Intersection) ?