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DLG4 and TRAF6
Number of citations of the paper that reports this interaction (PubMedID
28973854
)
66
Data Source:
BioGRID
(enzymatic study)
DLG4
TRAF6
Description
discs large MAGUK scaffold protein 4
TNF receptor associated factor 6
Image
GO Annotations
Cellular Component
Cytoplasm
Endoplasmic Reticulum
Cytosol
Plasma Membrane
Adherens Junction
Synaptic Vesicle
Voltage-gated Potassium Channel Complex
Postsynaptic Density
Membrane
Cell Junction
Axon
Dendrite
Endocytic Vesicle Membrane
Cortical Cytoskeleton
Neuromuscular Junction
AMPA Glutamate Receptor Complex
Dendrite Cytoplasm
Cell Projection
Neuron Projection
Dendritic Spine
Organelle
Juxtaparanode Region Of Axon
Cerebellar Mossy Fiber
Neuron Projection Terminus
Neuron Spine
Synapse
Postsynaptic Membrane
Excitatory Synapse
Cell Periphery
Synaptic Membrane
Presynapse
Postsynapse
Postsynaptic Density Membrane
Glutamatergic Synapse
Nucleus
Cytoplasm
Lipid Droplet
Cytosol
Plasma Membrane
Cell Cortex
Cytoplasmic Side Of Plasma Membrane
Endosome Membrane
Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane
Protein-containing Complex
CD40 Receptor Complex
Perinuclear Region Of Cytoplasm
Glutamatergic Synapse
Molecular Function
Protein Binding
Kinase Binding
Protein Kinase Binding
Protein Phosphatase Binding
PDZ Domain Binding
Protein-macromolecule Adaptor Activity
Beta-1 Adrenergic Receptor Binding
D1 Dopamine Receptor Binding
P2Y1 Nucleotide Receptor Binding
Acetylcholine Receptor Binding
Ionotropic Glutamate Receptor Binding
Protein-containing Complex Binding
Neuroligin Family Protein Binding
Scaffold Protein Binding
Ubiquitin-protein Transferase Activity
Tumor Necrosis Factor Receptor Binding
Protein Binding
Zinc Ion Binding
Transferase Activity
Enzyme Binding
Protein-macromolecule Adaptor Activity
Ubiquitin Conjugating Enzyme Binding
Ubiquitin-ubiquitin Ligase Activity
Signaling Adaptor Activity
Identical Protein Binding
Histone Deacetylase Binding
Protein Kinase B Binding
Metal Ion Binding
Ubiquitin Protein Ligase Activity
Biological Process
Negative Regulation Of Receptor Internalization
Signal Transduction
Positive Regulation Of Cytosolic Calcium Ion Concentration
Chemical Synaptic Transmission
Nervous System Development
Learning
Synaptic Vesicle Maturation
Social Behavior
Protein Localization To Synapse
Locomotory Exploration Behavior
Cellular Response To Potassium Ion
Establishment Of Protein Localization
Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity
Regulation Of Long-term Neuronal Synaptic Plasticity
Positive Regulation Of Synaptic Transmission
Neuromuscular Process Controlling Balance
Dendritic Spine Morphogenesis
Protein-containing Complex Assembly
Vocalization Behavior
AMPA Glutamate Receptor Clustering
Receptor Localization To Synapse
Cell-cell Adhesion
NMDA Selective Glutamate Receptor Signaling Pathway
Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels
Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane
Positive Regulation Of Neuron Projection Arborization
Positive Regulation Of Excitatory Postsynaptic Potential
Regulation Of Grooming Behavior
Autophagosome Assembly
Negative Regulation Of Transcription By RNA Polymerase II
Protein Polyubiquitination
Ossification
In Utero Embryonic Development
Neural Tube Closure
Stimulatory C-type Lectin Receptor Signaling Pathway
Immune System Process
Regulation Of Immunoglobulin Production
Positive Regulation Of T Cell Cytokine Production
Cytoplasmic Pattern Recognition Receptor Signaling Pathway
MyD88-dependent Toll-like Receptor Signaling Pathway
Immune Response
DNA Damage Response
Signal Transduction
Canonical NF-kappaB Signal Transduction
MRNA Transcription
Animal Organ Morphogenesis
Protein Ubiquitination
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II
CD40 Signaling Pathway
Osteoclast Differentiation
Positive Regulation Of Protein Ubiquitination
Lipopolysaccharide-mediated Signaling Pathway
Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway
Activation Of Protein Kinase Activity
Positive Regulation Of Type I Interferon Production
Positive Regulation Of Interleukin-12 Production
Positive Regulation Of Interleukin-2 Production
Positive Regulation Of Interleukin-6 Production
Tumor Necrosis Factor-mediated Signaling Pathway
Toll-like Receptor 3 Signaling Pathway
Toll-like Receptor 4 Signaling Pathway
TRIF-dependent Toll-like Receptor Signaling Pathway
Non-canonical NF-kappaB Signal Transduction
Fc-epsilon Receptor Signaling Pathway
Interleukin-33-mediated Signaling Pathway
Interleukin-17A-mediated Signaling Pathway
T-helper 1 Type Immune Response
Positive Regulation Of T Cell Proliferation
Odontogenesis Of Dentin-containing Tooth
Defense Response To Bacterium
Regulation Of Apoptotic Process
Myeloid Dendritic Cell Differentiation
Regulation Of Canonical NF-kappaB Signal Transduction
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Negative Regulation Of Canonical NF-kappaB Signal Transduction
Positive Regulation Of JUN Kinase Activity
Innate Immune Response
Bone Resorption
Positive Regulation Of Osteoclast Differentiation
Negative Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of JNK Cascade
Bone Remodeling
Cell Development
T Cell Receptor Signaling Pathway
Positive Regulation Of NF-kappaB Transcription Factor Activity
Protein Autoubiquitination
Interleukin-1-mediated Signaling Pathway
Protein K63-linked Ubiquitination
Response To Interleukin-1
Protein K48-linked Ubiquitination
Cellular Response To Lipopolysaccharide
Cellular Response To Cytokine Stimulus
Interleukin-17-mediated Signaling Pathway
Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane
Antiviral Innate Immune Response
Intracellular Signaling Cassette
Protein Branched Polyubiquitination
Cellular Response To Oxygen-containing Compound
Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell
Pathways
Signaling by ERBB4
Trafficking of AMPA receptors
Unblocking of NMDA receptors, glutamate binding and activation
Unblocking of NMDA receptors, glutamate binding and activation
Ras activation upon Ca2+ influx through NMDA receptor
NrCAM interactions
Activation of Ca-permeable Kainate Receptor
RHO GTPases activate CIT
RAF/MAP kinase cascade
LGI-ADAM interactions
Neurexins and neuroligins
Neurexins and neuroligins
Synaptic adhesion-like molecules
Assembly and cell surface presentation of NMDA receptors
Negative regulation of NMDA receptor-mediated neuronal transmission
Long-term potentiation
PIP3 activates AKT signaling
MyD88:MAL(TIRAP) cascade initiated on plasma membrane
NOD1/2 Signaling Pathway
TICAM1, RIP1-mediated IKK complex recruitment
Regulated proteolysis of p75NTR
Downstream TCR signaling
NRIF signals cell death from the nucleus
NRIF signals cell death from the nucleus
p75NTR recruits signalling complexes
NF-kB is activated and signals survival
FCERI mediated NF-kB activation
TAK1-dependent IKK and NF-kappa-B activation
activated TAK1 mediates p38 MAPK activation
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
CLEC7A (Dectin-1) signaling
Ub-specific processing proteases
Ovarian tumor domain proteases
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
TICAM1,TRAF6-dependent induction of TAK1 complex
Interleukin-1 signaling
TRAF6 mediated IRF7 activation
TRAF6 mediated NF-kB activation
TRAF6 mediated NF-kB activation
IRAK1 recruits IKK complex
IKK complex recruitment mediated by RIP1
IRAK2 mediated activation of TAK1 complex
TRAF6-mediated induction of TAK1 complex within TLR4 complex
Alpha-protein kinase 1 signaling pathway
SARS-CoV-1 activates/modulates innate immune responses
SARS-CoV-2 activates/modulates innate and adaptive immune responses
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
MyD88 dependent cascade initiated on endosome
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
Regulation of NF-kappa B signaling
MyD88 cascade initiated on plasma membrane
Drugs
Guanidine
Guanosine-5'-Monophosphate
Diseases
GWAS
Cholesterol, total (
24097068
25961943
)
Hematocrit (
32888494
)
Hemoglobin (
32888494
)
LDL cholesterol (
24097068
25961943
)
LDL cholesterol levels (
28334899
)
Liver enzyme levels (alkaline phosphatase) (
22001757
33972514
)
Serum alkaline phosphatase levels (
29403010
33547301
)
Idiopathic inflammatory myopathy (
26362759
)
Metabolite levels (
23823483
)
Rheumatoid arthritis (
24390342
30423114
)
Interacting Genes
139 interacting genes:
ABHD17A
ACTN2
ADGRB1
ADGRB2
ADGRL1
ADRB1
AKAP5
ARHGAP32
ARRB2
ASIC3
ATP2B2
ATP2B4
BEGAIN
CACNG2
CASK
CD46
CIT
CLU
CNKSR2
CRHR1
CRIPT
CYLD
DLG2
DLG3
DLGAP1
DLGAP2
DLGAP3
DLGAP4
DRD1
DSCAM
DYNLL1
EEF1G
EFNB2
ERBB2
ERBB4
ERBIN
EXOC4
FTH1
FYN
FZD1
FZD2
FZD4
FZD7
GDA
GLS2
GNG13
GOLGA2
GPSM2
GRIK1
GRIK2
GRIK5
GRIN1
GRIN2A
GRIN2B
GRIN2C
GRIN2D
GRIN3A
GRIN3B
GUCY1A2
HGS
HNRNPC
HTR2A
HTR2C
HTT
IL13RA1
KCNA1
KCNA2
KCNA3
KCNA4
KCNA5
KCND2
KCNJ10
KCNJ12
KCNJ2
KCNJ4
KHDRBS1
KIF13B
KIF1B
LIN7A
LIN7B
LRFN1
LRP1
LRP2
LRP8
LRRC1
LYN
LZTS2
MAP1A
MAP3K10
MAPK12
MDM2
MPND
MPP1
MT-CO1
NCKIPSD
NDOR1
NLGN1
NLGN2
NLGN3
NLGN4X
NOMO1
NOS1
PCDH10
PCMT1
PEX19
PICK1
PRKCA
PRR16
PTK2B
PTPRG
RALBP1
RASSF4
RPS6KA1
SCN5A
SEMA4B
SEMA4C
SEMA4F
SEMA4G
SHANK1
SHANK2
SIPA1L1
SLC4A7
SPRR2A
SRC
SYNGAP1
TAMALIN
TANC1
THOC3
TIAM1
TJAP1
TRAF6
TUBB2B
UBE3A
VANGL2
VMAC
WDR74
WNT3A
YES1
ZDHHC17
184 interacting genes:
ABL1
AKT1
APP
ATM
ATP6V1E1
ATXN3
BANK1
BCL3
BEX3
BMPR1B
BRSK2
CAV1
CBL
CD40
CUL5
CYLD
DLG4
DNA2
ECSIT
EDA2R
EDARADD
FADD
FAM177A1
FHL2
FYN
GART
GTF2I
H2AX
H2BC21
HNRNPA1
HSD17B10
HSPA4
IL17RB
IPMK
IQUB
IRAK1
IRAK2
IRAK3
IRAK4
IRF5
IRF7
IRF8
JAK2
KCNQ1
LIMD1
LNX1
MALT1
MAP2K1
MAP2K6
MAP2K7
MAP3K11
MAP3K14
MAP3K3
MAP3K5
MAP3K7
MAP3K8
MAPK14
MAPK8
MAPT
MAST2
MATR3
MAVS
MBP
MCL1
MEOX2
MTOR
MTURN
NEAT1
NGFR
NOL3
NTRK1
NTRK2
NUMBL
OTUB1
OTUB2
OTUD7B
PEDS1-UBE2V1
PELI3
PFN1
PHLDA1
PINK1
PLEKHF2
PLEKHO1
POLI
PPP4C
PRKCZ
PSMB5
PSMC1
PSMC2
PSMC3
PSMD1
PSMD12
PSMD13
PSMD6
PSMD7
PTPN6
RAD23A
RIPK1
RIPK2
RIPK3
RNF114
RNF152
RNF31
RPL3
RPS2
RPS20
RPS27A
RSAD2
SIGIRR
SPHK1
SPOP
SQSTM1
SRC
STAMBP
STK17A
STK26
STRADB
STUB1
SUFU
SYK
TAB1
TAB2
TAB3
TANK
TAX1BP1
TDP2
TGFBR1
TICAM1
TICAM2
TIFA
TIRAP
TLR3
TNFAIP3
TNFRSF11A
TNFRSF13B
TNFRSF19
TNFSF11
TRAF1
TRAF2
TRAF3IP1
TRAF3IP2
TRAF4
TRAF5
TRAF7
TRAFD1
TRAM1
TRIM17
TRIM25
TRIM37
TTC3
TXNIP
UBB
UBC
UBE2D1
UBE2D2
UBE2D3
UBE2D4
UBE2E1
UBE2I
UBE2L3
UBE2N
UBE2V1
UBOX5
UBTD1
UBXN7
UEVLD
USP1
USP15
USP2
USP21
USP39
USP7
VPS52
XIAP
YBX1
YES1
YOD1
YWHAQ
ZBTB25
ZDHHC11
ZFAND5
ZMYND11
ZNF675
ZRANB1
Entrez ID
1742
7189
HPRD ID
04199
03833
Ensembl ID
ENSG00000132535
ENSG00000175104
Uniprot IDs
A0A3B3IS17
B7Z4H2
B7Z647
B9EGL1
P78352
Q9Y4K3
PDB IDs
1KEF
2MES
3I4W
3K82
3ZRT
5J7J
5JXB
6QJD
6QJF
6QJG
6QJI
6QJJ
6QJK
6QJL
6QJN
6SPV
6SPZ
8AH4
8AH5
8AH6
8AH7
8AH8
1LB4
1LB5
1LB6
2ECI
2JMD
3HCS
3HCT
3HCU
4Z8M
5ZUJ
6A33
7L3L
8HZ2
Enriched GO Terms of Interacting Partners
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Synapse
Glutamatergic Synapse
Postsynaptic Density Membrane
Plasma Membrane
Postsynaptic Membrane
Modulation Of Chemical Synaptic Transmission
Postsynaptic Density
Regulation Of Membrane Potential
Regulation Of Biological Quality
Ionotropic Glutamate Receptor Signaling Pathway
Membrane
Regulation Of Signaling
Regulation Of Cell Communication
Scaffold Protein Binding
Synaptic Signaling
Chemical Synaptic Transmission
Dendrite
Regulation Of Synapse Organization
Trans-synaptic Signaling
Glutamate Receptor Signaling Pathway
Regulation Of Postsynaptic Membrane Potential
Signaling
Ligand-gated Ion Channel Signaling Pathway
Metal Ion Transport
Cell Communication
Presynaptic Membrane
NMDA Selective Glutamate Receptor Complex
PDZ Domain Binding
Monoatomic Cation Transport
Monoatomic Ion Transport
Positive Regulation Of Synaptic Transmission, Glutamatergic
Regulation Of Synaptic Transmission, Glutamatergic
Regulation Of System Process
Cell-cell Signaling
NMDA Glutamate Receptor Activity
Modulation Of Excitatory Postsynaptic Potential
Regulation Of Synaptic Plasticity
Dendritic Spine
Signal Transduction
Monoatomic Ion Channel Activity
Protein Localization To Synapse
Synaptic Transmission, Glutamatergic
Positive Regulation Of Excitatory Postsynaptic Potential
Ligand-gated Monoatomic Ion Channel Activity
Monoatomic Ion Channel Complex
Regulation Of Transport
Cell Surface Receptor Signaling Pathway
Regulation Of Monoatomic Ion Transmembrane Transport
Monoatomic Ion Transmembrane Transport
Regulation Of Synapse Assembly
Regulation Of Canonical NF-kappaB Signal Transduction
Positive Regulation Of Intracellular Signal Transduction
Regulation Of Intracellular Signal Transduction
Protein Modification Process
Protein Metabolic Process
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Positive Regulation Of Signal Transduction
Intracellular Signal Transduction
Regulation Of Signal Transduction
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Post-translational Protein Modification
Regulation Of Signaling
Regulation Of Cell Communication
Innate Immune Response-activating Signaling Pathway
Positive Regulation Of Defense Response
Pattern Recognition Receptor Signaling Pathway
Activation Of Innate Immune Response
Response To Stress
Immune Response-regulating Signaling Pathway
Regulation Of Defense Response
Modification-dependent Protein Catabolic Process
Proteolysis Involved In Protein Catabolic Process
Positive Regulation Of Innate Immune Response
Immune Response-activating Signaling Pathway
Cell Surface Receptor Signaling Pathway
Signal Transduction
Proteolysis
Cytosol
Activation Of Immune Response
Ubiquitin-dependent Protein Catabolic Process
Ubiquitin Protein Ligase Binding
Protein Polyubiquitination
Positive Regulation Of Immune Response
Regulation Of Innate Immune Response
Macromolecule Metabolic Process
Regulation Of Immune Response
Defense Response
Protein Kinase Activity
MAPK Cascade
Cytoplasmic Pattern Recognition Receptor Signaling Pathway
Regulation Of Apoptotic Process
Regulation Of Programmed Cell Death
Transferase Activity
Negative Regulation Of Signal Transduction
Regulation Of Cytokine-mediated Signaling Pathway
Protein Ubiquitination
Positive Regulation Of Protein Metabolic Process
Positive Regulation Of Immune System Process
Negative Regulation Of Signaling
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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