DLG4 and ERBB2

Number of citations of the paper that reports this interaction (PubMedID 10839362)
0

Data Source:
BioGRID (affinity chromatography technology, biochemical)
HPRD (two hybrid, in vivo)

		DLG4	ERBB2
Description		discs large MAGUK scaffold protein 4	erb-b2 receptor tyrosine kinase 2
Image
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Cytosol Plasma Membrane Adherens Junction Synaptic Vesicle Voltage-gated Potassium Channel Complex Postsynaptic Density Membrane Cell Junction Axon Dendrite Endocytic Vesicle Membrane Cortical Cytoskeleton Neuromuscular Junction AMPA Glutamate Receptor Complex Dendrite Cytoplasm Cell Projection Neuron Projection Dendritic Spine Organelle Juxtaparanode Region Of Axon Cerebellar Mossy Fiber Neuron Projection Terminus Neuron Spine Synapse Postsynaptic Membrane Excitatory Synapse Cell Periphery Synaptic Membrane Presynapse Postsynapse Postsynaptic Density Membrane Glutamatergic Synapse	Semaphorin Receptor Complex Nucleus Nucleoplasm Cytoplasm Endosome Early Endosome Cytosol Plasma Membrane Basal Plasma Membrane Endosome Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane Cytoplasmic Vesicle Neuromuscular Junction Ruffle Membrane ERBB3:ERBB2 Complex Presynaptic Membrane Cell Projection Myelin Sheath Receptor Complex Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding Kinase Binding Protein Kinase Binding Protein Phosphatase Binding PDZ Domain Binding Protein-macromolecule Adaptor Activity Beta-1 Adrenergic Receptor Binding D1 Dopamine Receptor Binding P2Y1 Nucleotide Receptor Binding Acetylcholine Receptor Binding Ionotropic Glutamate Receptor Binding Protein-containing Complex Binding Neuroligin Family Protein Binding Scaffold Protein Binding	Nucleotide Binding RNA Polymerase I Core Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Transmembrane Signaling Receptor Activity Signaling Receptor Binding Protein Binding ATP Binding Coreceptor Activity Kinase Activity Transferase Activity Growth Factor Binding Receptor Tyrosine Kinase Binding Identical Protein Binding ErbB-3 Class Receptor Binding Protein Heterodimerization Activity
	Biological Process	Negative Regulation Of Receptor Internalization Signal Transduction Positive Regulation Of Cytosolic Calcium Ion Concentration Chemical Synaptic Transmission Nervous System Development Learning Synaptic Vesicle Maturation Social Behavior Protein Localization To Synapse Locomotory Exploration Behavior Cellular Response To Potassium Ion Establishment Of Protein Localization Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Regulation Of Long-term Neuronal Synaptic Plasticity Positive Regulation Of Synaptic Transmission Neuromuscular Process Controlling Balance Dendritic Spine Morphogenesis Protein-containing Complex Assembly Vocalization Behavior AMPA Glutamate Receptor Clustering Receptor Localization To Synapse Cell-cell Adhesion NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Positive Regulation Of Neuron Projection Arborization Positive Regulation Of Excitatory Postsynaptic Potential Regulation Of Grooming Behavior	Protein Phosphorylation Signal Transduction Cell Surface Receptor Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Nervous System Development Peripheral Nervous System Development Heart Development Neuromuscular Junction Development Motor Neuron Axon Guidance Cell Population Proliferation Positive Regulation Of Gene Expression Schwann Cell Development Peptidyl-tyrosine Phosphorylation Neuron Differentiation Positive Regulation Of Cell Growth Regulation Of Microtubule-based Process Immature T Cell Proliferation In Thymus Negative Regulation Of Immature T Cell Proliferation In Thymus Positive Regulation Of Rho Protein Signal Transduction Intracellular Signal Transduction ERBB2 Signaling Pathway ERBB2-ERBB3 Signaling Pathway ERBB2-EGFR Signaling Pathway ERBB2-ERBB4 Signaling Pathway Wound Healing Regulation Of Cell Population Proliferation Myelination Negative Regulation Of Apoptotic Process Positive Regulation Of MAP Kinase Activity Positive Regulation Of MAPK Cascade Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Translation Regulation Of Angiogenesis Positive Regulation Of Cell Adhesion Positive Regulation Of Transcription By RNA Polymerase I Oligodendrocyte Differentiation Positive Regulation Of Epithelial Cell Proliferation Regulation Of ERK1 And ERK2 Cascade Cellular Response To Growth Factor Stimulus Cellular Response To Epidermal Growth Factor Stimulus Semaphorin-plexin Signaling Pathway Positive Regulation Of Protein Targeting To Membrane Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Positive Regulation Of Intracellular Signal Transduction
Pathways		Signaling by ERBB4 Trafficking of AMPA receptors Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation Ras activation upon Ca2+ influx through NMDA receptor NrCAM interactions Activation of Ca-permeable Kainate Receptor RHO GTPases activate CIT RAF/MAP kinase cascade LGI-ADAM interactions Neurexins and neuroligins Neurexins and neuroligins Synaptic adhesion-like molecules Assembly and cell surface presentation of NMDA receptors Negative regulation of NMDA receptor-mediated neuronal transmission Long-term potentiation	Signaling by ERBB2 SHC1 events in ERBB2 signaling SHC1 events in ERBB2 signaling PLCG1 events in ERBB2 signaling PIP3 activates AKT signaling GRB7 events in ERBB2 signaling Downregulation of ERBB2:ERBB3 signaling GRB2 events in ERBB2 signaling GRB2 events in ERBB2 signaling PI3K events in ERBB2 signaling Constitutive Signaling by Aberrant PI3K in Cancer Sema4D induced cell migration and growth-cone collapse RAF/MAP kinase cascade ERBB2 Regulates Cell Motility PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling ERBB2 Activates PTK6 Signaling Downregulation of ERBB2 signaling TFAP2 (AP-2) family regulates transcription of growth factors and their receptors Constitutive Signaling by Overexpressed ERBB2 Drug-mediated inhibition of ERBB2 signaling Signaling by ERBB2 KD Mutants Resistance of ERBB2 KD mutants to trastuzumab Resistance of ERBB2 KD mutants to sapitinib Resistance of ERBB2 KD mutants to tesevatinib Resistance of ERBB2 KD mutants to neratinib Resistance of ERBB2 KD mutants to osimertinib Resistance of ERBB2 KD mutants to afatinib Resistance of ERBB2 KD mutants to AEE788 Resistance of ERBB2 KD mutants to lapatinib Signaling by ERBB2 ECD mutants Signaling by ERBB2 TMD/JMD mutants Drug resistance in ERBB2 TMD/JMD mutants Developmental Lineage of Mammary Gland Luminal Epithelial Cells Developmental Lineage of Mammary Gland Myoepithelial Cells Developmental Lineage of Mammary Stem Cells
Drugs		Guanidine Guanosine-5'-Monophosphate	Trastuzumab Lapatinib IGN311 Trastuzumab emtansine Varlitinib AV-412 Pertuzumab Afatinib Tucatinib Tesevatinib Fostamatinib Brigatinib Margetuximab Zanubrutinib
Diseases			Breast cancer Cervical cancer Cholangiocarcinoma Pancreatic cancer Gastric cancer Ovarian cancer Choriocarcinoma Endometrial Cancer Bladder cancer
GWAS		Cholesterol, total ( 24097068 25961943) Hematocrit ( 32888494) Hemoglobin ( 32888494) LDL cholesterol ( 24097068 25961943) LDL cholesterol levels ( 28334899) Liver enzyme levels (alkaline phosphatase) ( 22001757 33972514) Serum alkaline phosphatase levels ( 29403010 33547301)	Adult asthma ( 30787307) Asthma ( 29273806 31619474) Asthma or allergic disease (pleiotropy) ( 29785011) Bipolar disorder ( 27329760 34002096) Estimated glomerular filtration rate ( 31451708) Pancreatic ductal adenocarcinoma ( 30541042) Polycystic ovary syndrome ( 26416764) Refractive error ( 32231278) Systemic lupus erythematosus ( 26502338 28714469) Ulcerative colitis ( 20228799)
Interacting Genes		139 interacting genes: ABHD17A ACTN2 ADGRB1 ADGRB2 ADGRL1 ADRB1 AKAP5 ARHGAP32 ARRB2 ASIC3 ATP2B2 ATP2B4 BEGAIN CACNG2 CASK CD46 CIT CLU CNKSR2 CRHR1 CRIPT CYLD DLG2 DLG3 DLGAP1 DLGAP2 DLGAP3 DLGAP4 DRD1 DSCAM DYNLL1 EEF1G EFNB2 ERBB2 ERBB4 ERBIN EXOC4 FTH1 FYN FZD1 FZD2 FZD4 FZD7 GDA GLS2 GNG13 GOLGA2 GPSM2 GRIK1 GRIK2 GRIK5 GRIN1 GRIN2A GRIN2B GRIN2C GRIN2D GRIN3A GRIN3B GUCY1A2 HGS HNRNPC HTR2A HTR2C HTT IL13RA1 KCNA1 KCNA2 KCNA3 KCNA4 KCNA5 KCND2 KCNJ10 KCNJ12 KCNJ2 KCNJ4 KHDRBS1 KIF13B KIF1B LIN7A LIN7B LRFN1 LRP1 LRP2 LRP8 LRRC1 LYN LZTS2 MAP1A MAP3K10 MAPK12 MDM2 MPND MPP1 MT-CO1 NCKIPSD NDOR1 NLGN1 NLGN2 NLGN3 NLGN4X NOMO1 NOS1 PCDH10 PCMT1 PEX19 PICK1 PRKCA PRR16 PTK2B PTPRG RALBP1 RASSF4 RPS6KA1 SCN5A SEMA4B SEMA4C SEMA4F SEMA4G SHANK1 SHANK2 SIPA1L1 SLC4A7 SPRR2A SRC SYNGAP1 TAMALIN TANC1 THOC3 TIAM1 TJAP1 TRAF6 TUBB2B UBE3A VANGL2 VMAC WDR74 WNT3A YES1 ZDHHC17	347 interacting genes: AATK ABCB5 ABL1 ABL2 ACP1 ACP3 ADGRB1 AIP AKAP12 AKT1 ALDOA ALDOC ALK ANKS1A ANKS1B ANXA6 AP3B2 APBB1 APBB3 ARF1 ARF5 ARNT ASRGL1 ATP6AP1 ATP6V0C AURKA BAAT BCAR3 BECN1 BLK BLNK BMX BNIP1 BTC CACYBP CALM1 CAV1 CBLC CBR1 CCDC180 CCND2 CCT3 CD82 CDK4 CDK6 CDK8 CDKN2B CDKN2C CEND1 CFAP298 CFL1 CHN1 CISH CKB CLASP2 CLCN6 CLNK COL9A2 COL9A3 CRIP2 CRK CRKL CSDE1 CTNNB1 CXCL8 CYLC2 CYP17A1 DAB1 DDR1 DLG4 DOK1 DOK4 DOK6 DST DUSP14 DUSP18 DUSP19 EGF EGFR EPHA1 EPHA3 EPHA4 EPHB1 EPHB3 EPHB6 ERBB3 ERBB4 ERBIN ERG28 ERRFI1 ESR1 FAM241B FBP1 FBXO7 FER FES FGFR1 FGFR2 FGFR3 FGFR4 FGR FKBP1A FKBP3 FKBP8 FLNB FLT3 FLT4 FRAT2 FZR1 GAB1 GABARAPL1 GABARAPL2 GAPDH GLCE GLIS2 GLRX3 GMPR2 GPM6B GRAP2 GRB10 GRB14 GRB2 GRB7 GRK2 GRM1 GSN HCK HDAC6 HDLBP HGF HLA-A HRAS HSD17B3 HSH2D HSP90AA1 HSP90AB1 HSP90B1 HSPA1A HSPA5 HSPA9 HSPD1 IARS1 IGF1R IL13RA2 IL6ST ILF3 ILKAP INPPL1 INSR IRF2BP2 IRS1 IRS4 ITGA5 ITGB4 ITK ITPKA ITPR1 JAK1 JAK2 JMJD4 JUP KCTD6 KDELR2 KLC1 KLK5 LATS2 LCK LCP2 LGALS8 LPCAT4 LRRC7 LYPD3 MAP2K1 MAP2K3 MAP2K5 MAPK8IP1 MAPK8IP2 MATK MDH1 MEPCE MERTK MET MSN MST1R MTCH1 MUC1 MUC4 MUCL1 MYC MYO9A NAT2 NCK1 NCK2 NEFH NF2 NINL NRG1 NTRK1 NTRK2 NTRK3 NUDT16L1 ODF2L PABPC1 PAK1 PARP1 PDCD11 PDGFRA PDGFRB PEBP1 PGAM1 PHF23 PICK1 PIK3C2A PIK3C2B PIK3R1 PIK3R2 PIK3R3 PIN4 PLCG1 PLCG2 POLD2 POU6F1 PPA1 PPM1A PPM1F PRDM14 PRDX5 PSAP PSMA1 PSMC3 PSMC3IP PSMD3 PTGES3L-AARSD1 PTK2 PTK2B PTK6 PTK7 PTPN11 PTPN18 PTPN6 PTPRR PTPRT PTPRU RAB5C RAF1 RASA1 RASSF1 RBM15B RET RHBDD2 RHOBTB2 RIN1 RIN2 ROR2 RPRML RTN4 S100A11 SAFB2 SELENOK SERPINA3 SFRP4 SH2B1 SH2B2 SH2B3 SH2D1A SH2D1B SH2D2A SH2D3A SH2D3C SH2D5 SH3BGRL3 SH3BP2 SHB SHC1 SHC2 SHC3 SHC4 SHD SLA SLA2 SLC7A4 SMAD1 SMIM20 SMPD4 SMURF2 SNAP91 SOCS1 SOCS3 SOCS5 SOCS6 SORL1 SOS1 SPP1 SRC SRPK1 STAP1 STAT3 STIP1 STK11 STK24 STMN1 STMN2 STUB1 STYK1 STYX SUPT6H SYK SYNM TCEAL2 TEC TGFA TGFB1 THRSP TLN1 TMA7 TMEM134 TMEM230 TNS1 TNS2 TNS3 TOB1 TP53 TRIP6 TRMO TSEN15 TTC9B TTYH2 TVP23B TXK TXN TYMP TYRO3 UBB USP2 UTP18 VAPA VAV1 VAV2 VAV3 YES1 YWHAZ ZAP70 ZFAND1 ZMAT2 ZMYND8 ZNF189 ZNF532
Entrez ID		1742	2064
HPRD ID		04199	01281
Ensembl ID		ENSG00000132535	ENSG00000141736
Uniprot IDs		A0A3B3IS17 B7Z4H2 B7Z647 B9EGL1 P78352	B4DTR1 F5H1T4 J3QLU9 P04626 X5DNK3
PDB IDs		1KEF 2MES 3I4W 3K82 3ZRT 5J7J 5JXB 6QJD 6QJF 6QJG 6QJI 6QJJ 6QJK 6QJL 6QJN 6SPV 6SPZ 8AH4 8AH5 8AH6 8AH7 8AH8	1MFG 1MFL 1MW4 1N8Z 1QR1 1S78 2A91 2JWA 2KS1 2L4K 2N2A 3BE1 3H3B 3MZW 3N85 3PP0 3RCD 3WLW 3WSQ 4GFU 4HRL 4HRM 4HRN 4NND 5K33 5KWG 5MY6 5O4G 5OB4 5TQS 6ATT 6BGT 6J71 6LBX 6OGE 7JXH 7MN5 7MN6 7MN8 7PCD 7QVK 8FFJ 8HGO 8HGP 8JYQ 8JYR 8PWH 8Q6J 8U4K 8U4L 8U8X 8VB5 8VQD 8VQE 9L1S
Enriched GO Terms of Interacting Partners?		Synapse Glutamatergic Synapse Postsynaptic Density Membrane Plasma Membrane Postsynaptic Membrane Modulation Of Chemical Synaptic Transmission Postsynaptic Density Regulation Of Membrane Potential Regulation Of Biological Quality Ionotropic Glutamate Receptor Signaling Pathway Membrane Regulation Of Signaling Regulation Of Cell Communication Scaffold Protein Binding Synaptic Signaling Chemical Synaptic Transmission Dendrite Regulation Of Synapse Organization Trans-synaptic Signaling Glutamate Receptor Signaling Pathway Regulation Of Postsynaptic Membrane Potential Signaling Ligand-gated Ion Channel Signaling Pathway Metal Ion Transport Cell Communication Presynaptic Membrane NMDA Selective Glutamate Receptor Complex PDZ Domain Binding Monoatomic Cation Transport Monoatomic Ion Transport Positive Regulation Of Synaptic Transmission, Glutamatergic Regulation Of Synaptic Transmission, Glutamatergic Regulation Of System Process Cell-cell Signaling NMDA Glutamate Receptor Activity Modulation Of Excitatory Postsynaptic Potential Regulation Of Synaptic Plasticity Dendritic Spine Signal Transduction Monoatomic Ion Channel Activity Protein Localization To Synapse Synaptic Transmission, Glutamatergic Positive Regulation Of Excitatory Postsynaptic Potential Ligand-gated Monoatomic Ion Channel Activity Monoatomic Ion Channel Complex Regulation Of Transport Cell Surface Receptor Signaling Pathway Regulation Of Monoatomic Ion Transmembrane Transport Monoatomic Ion Transmembrane Transport Regulation Of Synapse Assembly	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Protein Tyrosine Kinase Activity Cell Surface Receptor Signaling Pathway Phosphotyrosine Residue Binding Signal Transduction Protein Kinase Activity Regulation Of Signal Transduction ERBB Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Activity Regulation Of Cell Communication Regulation Of Signaling Peptidyl-tyrosine Phosphorylation Kinase Activity Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Non-membrane Spanning Protein Tyrosine Kinase Activity Cytosol Regulation Of MAPK Cascade Positive Regulation Of Intracellular Signal Transduction Protein Autophosphorylation Protein Phosphorylation Phosphorylation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Plasma Membrane ATP Binding Ephrin Receptor Signaling Pathway Positive Regulation Of Cell Motility Cell Migration Positive Regulation Of Locomotion Protein Kinase Binding Intracellular Signaling Cassette Positive Regulation Of Cell Migration Positive Regulation Of MAPK Cascade Regulation Of Cell Motility Phosphate-containing Compound Metabolic Process Regulation Of Locomotion Regulation Of Cell Population Proliferation Regulation Of Cell Adhesion Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cell Motility Regulation Of Cell Migration Focal Adhesion Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Cellular Component Organization Nucleotide Binding
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