DLG4 and NDOR1

Number of citations of the paper that reports this interaction (PMID 7569905)
284

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		DLG4	NDOR1
Gene Name		discs, large homolog 4 (Drosophila)	NADPH dependent diflavin oxidoreductase 1
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Plasma Membrane Synaptic Vesicle Voltage-gated Potassium Channel Complex Ionotropic Glutamate Receptor Complex Postsynaptic Density Basolateral Plasma Membrane Cell Junction Endocytic Vesicle Membrane Cortical Cytoskeleton Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid Selective Glutamate Receptor Complex Dendrite Cytoplasm Dendritic Spine Juxtaparanode Region Of Axon Cerebellar Mossy Fiber Neuron Projection Terminus Neuron Spine Synapse Postsynaptic Membrane Excitatory Synapse Neuronal Postsynaptic Density	Nucleus Cytoplasm Cytosol Intermediate Filament Cytoskeleton Perinuclear Region Of Cytoplasm
	Molecular Function	Guanylate Kinase Activity Protein Binding Protein C-terminus Binding Protein Phosphatase Binding PDZ Domain Binding Beta-1 Adrenergic Receptor Binding D1 Dopamine Receptor Binding P2Y1 Nucleotide Receptor Binding Protein Complex Binding Acetylcholine Receptor Binding Ionotropic Glutamate Receptor Binding Scaffold Protein Binding	NADPH-hemoprotein Reductase Activity Iron Ion Binding Protein Binding FMN Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, NAD(P)H As One Donor, And Incorporation Of One Atom Of Oxygen Flavin Adenine Dinucleotide Binding NADP Binding
	Biological Process	Negative Regulation Of Receptor Internalization Protein Complex Assembly Signal Transduction Positive Regulation Of Cytosolic Calcium Ion Concentration Synaptic Transmission Nervous System Development Axon Guidance Learning Synaptic Vesicle Maturation Social Behavior Protein Localization To Synapse Locomotory Exploration Behavior Establishment Of Protein Localization Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Nucleotide Phosphorylation Regulation Of Long-term Neuronal Synaptic Plasticity Positive Regulation Of Synaptic Transmission Neuromuscular Process Controlling Balance Dendritic Spine Morphogenesis Vocalization Behavior Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Clustering Receptor Localization To Synapse Regulation Of N-methyl-D-aspartate Selective Glutamate Receptor Activity Positive Regulation Of Excitatory Postsynaptic Membrane Potential Regulation Of Grooming Behavior	Cell Death Iron-sulfur Cluster Assembly Cellular Response To Menadione Small Molecule Metabolic Process Oxidation-reduction Process
Pathways		Axon guidance L1CAM interactions Activation of Kainate Receptors upon glutamate binding CREB phosphorylation through the activation of Ras Trafficking of AMPA receptors Activation of NMDA receptor upon glutamate binding and postsynaptic events CREB phosphorylation through the activation of CaMKII NrCAM interactions Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity Activation of Ca-permeable Kainate Receptor Unblocking of NMDA receptor, glutamate binding and activation Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Ionotropic activity of Kainate Receptors Ras activation uopn Ca2+ infux through NMDA receptor Post NMDA receptor activation events Transmission across Chemical Synapses	Cytosolic iron-sulfur cluster assembly
Drugs
Diseases
GWAS		Liver enzyme levels (alkaline phosphatase) ( 22001757)
Protein-Protein Interactions		104 interactors: ACTN2 ADRB1 AKAP5 ARHGAP32 ASIC3 ATP2B2 ATP2B4 BAI1 BEGAIN CACNG2 CASK CD46 CIT CNKSR2 CRIPT DLG2 DLG3 DLGAP1 DLGAP2 DLGAP3 DLGAP4 DYNLL1 EFNB2 ERBB2 ERBB2IP ERBB4 EXOC4 FYN FZD1 FZD2 FZD4 FZD7 GDA GLS2 GNG13 GRASP GRIK1 GRIK2 GRIK5 GRIN1 GRIN2A GRIN2B GRIN2C GRIN2D GRIN3A GRIN3B GUCY1A2 HGS HTR2A HTR2C HTT IL13RA1 KCNA1 KCNA2 KCNA3 KCNA4 KCNA5 KCND2 KCNJ10 KCNJ12 KCNJ2 KCNJ4 KHDRBS1 KIF13B KIF1B LIN7A LIN7B LPHN1 LRFN1 LRP1 LRP2 LRP8 LRRC1 LYN MAP1A MAP3K10 MAPK12 MDM2 NCKIPSD NDOR1 NLGN1 NLGN2 NLGN3 NLGN4X NOS1 PCDH10 PRKCA PTK2B PTPRG SCN5A SEMA4B SEMA4C SEMA4F SEMA4G SHANK1 SHANK2 SIPA1L1 SPRR2A SRC SYNGAP1 TANC1 WNT3A YES1 ZDHHC17	8 interactors: CCDC33 CIAPIN1 CYCS DLG4 EFHC2 MTUS2 TCF4 TCHP
Entrez ID		1742	27158
HPRD ID		04199	10444
Ensembl ID		ENSG00000132535	ENSG00000188566
Uniprot IDs		B7Z647 B9EGL1 P78352	D3YTG6 Q9UHB4
PDB IDs		1KEF 3I4W 3K82 3ZRT	4H2D
Enriched GO Terms of Interacting Partners?		Cell-cell Signaling Synaptic Transmission Signaling Cell Communication Regulation Of Membrane Potential Regulation Of Ion Transport Regulation Of Ion Transmembrane Transport Membrane Depolarization Nervous System Development Regulation Of Postsynaptic Membrane Potential Regulation Of Signaling Ionotropic Glutamate Receptor Signaling Pathway Regulation Of Synaptic Transmission Regulation Of Excitatory Postsynaptic Membrane Potential Neurological System Process Neuron-neuron Synaptic Transmission Glutamate Receptor Signaling Pathway Signal Transduction Metal Ion Transport Synaptic Transmission, Glutamatergic Neurogenesis Response To Stimulus Ion Transport Generation Of Neurons Cellular Response To Stimulus Transport System Development Cation Transport Cell Surface Receptor Signaling Pathway Single-organism Behavior Sensory Perception Of Pain Behavior Neuron Differentiation Regulation Of Signal Transduction Response To Abiotic Stimulus Ion Transmembrane Transport Regulation Of Cellular Localization Anatomical Structure Development Regulation Of Cellular Process Membrane Hyperpolarization Cell Differentiation Cation Transmembrane Transport Multicellular Organismal Development Developmental Process Regulation Of Phosphorus Metabolic Process Learning Response To External Stimulus Cellular Process Neuron Development Positive Regulation Of Signal Transduction	Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Epithelial To Mesenchymal Transition Catenin Import Into Nucleus Positive Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process Apoptotic Process Programmed Cell Death Vesicle Localization Maintenance Of DNA Repeat Elements Mitochondrial Electron Transport, Cytochrome C To Oxygen Cell Death Death Negative Regulation Of Growth Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Clustering Regulation Of Grooming Behavior Embryonic Hindgut Morphogenesis Negative Regulation Of Type B Pancreatic Cell Apoptotic Process Maintenance Of Apical/basal Cell Polarity Embryonic Genitalia Morphogenesis Receptor Localization To Synapse Myoblast Fate Commitment Energy Derivation By Oxidation Of Organic Compounds Negative Regulation Of Receptor Internalization Mitochondrial Electron Transport, Ubiquinol To Cytochrome C Secretory Granule Localization Locomotory Exploration Behavior Regulation Of Apoptotic Process Hindgut Morphogenesis Dendritic Spine Morphogenesis Synaptic Vesicle Maturation Insulin Metabolic Process Maintenance Of Cell Polarity Regulation Of Cell Death Hindgut Development Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C Vocalization Behavior Positive Regulation Of Protein Export From Nucleus Positive Regulation Of Glycoprotein Biosynthetic Process Generation Of Precursor Metabolites And Energy Organelle Localization Positive Regulation Of Triglyceride Biosynthetic Process Positive Regulation Of Glycoprotein Metabolic Process Dendritic Spine Development Protein Localization To Synapse Positive Regulation Of Gluconeogenesis Negative Regulation Of Receptor-mediated Endocytosis Regulation Of Triglyceride Biosynthetic Process Genitalia Morphogenesis Apoptotic DNA Fragmentation Regulation Of N-methyl-D-aspartate Selective Glutamate Receptor Activity Dendritic Spine Organization Cellular Component Assembly
Tagcloud ?		6g1 alleviated amyloid ca1 counteract densities distant fibrillar immunohistochemically immunotherapy oligomer oligomeric oligomers plaque plaques presynapses psd95 quantified reservoirs sequestering suffices synapse synapses synapsin synaptotoxic tg2576 unchanged unspecific vicinity	abcc3 agilent ankrd46 begins bonferroni c1orf9 c6orf62 cd47 chernobyl david fallout fgfr1op2 frozen hey2 hnrnph1 hybridised iodine kruskal multistep panther purposes qrt representation scel serpina1 ucp3 ukrainian unirradiated wallis
Tagcloud (Difference) ?		6g1 alleviated amyloid ca1 counteract densities distant fibrillar immunohistochemically immunotherapy oligomer oligomeric oligomers plaque plaques presynapses psd95 quantified reservoirs sequestering suffices synapse synapses synapsin synaptotoxic tg2576 unchanged unspecific vicinity	abcc3 agilent ankrd46 begins bonferroni c1orf9 c6orf62 cd47 chernobyl david fallout fgfr1op2 frozen hey2 hnrnph1 hybridised iodine kruskal multistep panther purposes qrt representation scel serpina1 ucp3 ukrainian unirradiated wallis
Tagcloud (Intersection) ?