PAX7 and FHL1

Number of citations of the paper that reports this interaction (PubMedID 23414517)
48

Data Source:
BioGRID (two hybrid)

		PAX7	FHL1
Description		paired box 7	four and a half LIM domains 1
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus	Nucleus Cytoplasm Cytosol Plasma Membrane Focal Adhesion
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding	Protein Binding Zinc Ion Binding Transmembrane Transporter Binding Metal Ion Binding Channel Activator Activity Potassium Channel Activator Activity
	Biological Process	Chromatin Remodeling Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Nervous System Development Muscle Organ Development Skeletal Muscle Tissue Development Anatomical Structure Morphogenesis Regulation Of Cell Fate Commitment Regulation Of Gene Expression Skeletal Muscle Satellite Cell Commitment Skeletal Muscle Satellite Cell Differentiation Spinal Cord Association Neuron Differentiation Dorsal/ventral Neural Tube Patterning Negative Regulation Of Apoptotic Process Skeletal Muscle Tissue Regeneration Positive Regulation Of Transcription By RNA Polymerase II Neuron Fate Commitment Embryonic Skeletal System Development Cartilage Development Muscle Tissue Morphogenesis Regulation Of Chromatin Organization Positive Regulation Of Myoblast Proliferation	Muscle Organ Development Animal Organ Morphogenesis Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Cell Differentiation Negative Regulation Of Cell Growth Regulation Of Atrial Cardiac Muscle Cell Membrane Depolarization Positive Regulation Of Potassium Ion Transmembrane Transport Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways		Specification of the neural plate border
Drugs
Diseases		Alveolar rhabdomyosarcoma	X-linked myopathy with postural muscle atrophy (XMPMA) Scapuloperoneal myopathy (SPM) Reducing body myopathy (RBM) Emery-Dreifuss muscular dystrophy
GWAS		Body mass index ( 23669352) Cortical surface area (visual PC2) ( 32198502) Knee osteoarthritis ( 28916551) Nonsyndromic cleft lip with cleft palate ( 28232668) Nonsyndromic cleft lip with or without cleft palate ( 33898419) Orofacial cleft x maternal periconceptional alcohol use interaction (2df) ( 33937227) Orofacial cleft x maternal periconceptional multivitamin use interaction (2df) ( 33937227) Orofacial cleft x maternal periconceptional smoking interaction (2df) ( 33937227) Orofacial clefts ( 22863734) Percentage gas trapping ( 26030696) Response to amphetamines ( 22952603) Urate levels in lean individuals ( 25811787)
Interacting Genes		14 interacting genes: AIRIM CIB1 CSNK2A1 CT55 FHL1 HIRA HNF1B HOMER3 KRTAP19-7 MAGOHB NEDD4 NFIC NFIX TCAP	30 interacting genes: APP CBX4 CHEK2 CLMN CSRP3 DBN1 DEAF1 DOCK9 EED ENO1 FHL2 HES1 HIVEP3 IGFBP5 LAMA4 MACF1 MYBPC1 NFIL3 PAX7 PDE4DIP PDLIM3 RBPJ RING1 SRF SRPK1 TTN TXNIP USP15 YWHAE ZBTB40
Entrez ID		5081	2273
HPRD ID		01331	02157
Ensembl ID		ENSG00000009709	ENSG00000022267
Uniprot IDs		P23759	B7Z9A1 Q13642 Q5JXI2
PDB IDs			1X63 2CUP 2CUR 2EGQ
Enriched GO Terms of Interacting Partners?		Transmembrane Transporter Binding Negative Regulation Of Macromolecule Biosynthetic Process Protein Targeting Negative Regulation Of Metabolic Process RNA Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Protein Targeting To Vacuole Nucleic Acid Metabolic Process Animal Organ Morphogenesis DNA-templated Transcription Formation Of Structure Involved In A Symbiotic Process Epithelial Tube Formation Mesonephric Duct Formation Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Mesonephric Nephron Morphogenesis Ureteric Bud Elongation Pronephric Nephron Tubule Development Mesenchymal Cell Apoptotic Process Involved In Metanephros Development HIR Complex Regulation Of Calcineurin-NFAT Signaling Cascade Regulation Of Calcineurin-mediated Signaling Positive Regulation Of Male Germ Cell Proliferation Anatomical Structure Morphogenesis Negative Regulation Of Nucleobase-containing Compound Metabolic Process Establishment Of Protein Localization To Vacuole Regulation Of Growth Regulation Of Potassium Ion Transmembrane Transport Channel Inhibitor Activity Chromatin Hepatoblast Differentiation Regulation Of Pronephros Size Titin-telethonin Complex Titin Z Domain Binding Sarcomerogenesis Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body Regulation Of Potassium Ion Transport Phosphothreonine Residue Binding Transcription By RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Branch Elongation Involved In Ureteric Bud Branching Mesonephric Duct Morphogenesis Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Metanephros Development Skeletal Muscle Myosin Thick Filament Assembly G Protein-coupled Glutamate Receptor Binding Endomitotic Cell Cycle Calcium-dependent Protein Kinase Inhibitor Activity Exon-exon Junction Subcomplex Mago-y14 Zinc Ion Import Into Golgi Lumen Protein Localization To Vacuole	Regulation Of RNA Metabolic Process Negative Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Sarcomere Organization Structural Constituent Of Muscle Negative Regulation Of RNA Metabolic Process Cardiac Myofibril Assembly Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Nucleobase-containing Compound Metabolic Process Cellular Developmental Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Nucleus M Band Aorta Morphogenesis Chromatin Binding Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Supramolecular Fiber Organization Myofibril Assembly Developmental Process Negative Regulation Of Macromolecule Biosynthetic Process Actin Binding Actomyosin Structure Organization Negative Regulation Of Biosynthetic Process Sex Chromatin Detection Of Muscle Stretch Telethonin Binding Cell Differentiation Negative Regulation Of Metabolic Process Transcription Corepressor Binding Z Disc Dorsal Aorta Morphogenesis Cardiac Muscle Cell Myoblast Differentiation Negative Regulation Of Macromolecule Metabolic Process Artery Morphogenesis Cadherin Binding Regulation Of Timing Of Cell Differentiation Cardioblast Differentiation Cytoskeleton Organization Heart Trabecula Formation Regulation Of Development, Heterochronic Actinin Binding Muscle Tissue Morphogenesis Muscle Alpha-actinin Binding
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