OSM and TNNT1

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		OSM	TNNT1
Description		oncostatin M	troponin T1, slow skeletal type
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Cytosol Troponin Complex
	Molecular Function	Signaling Receptor Binding Cytokine Activity Oncostatin-M Receptor Binding Protein Binding Growth Factor Activity	Protein Binding Tropomyosin Binding Troponin T Binding
	Biological Process	Positive Regulation Of Acute Inflammatory Response Immune Response Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Interleukin-17 Production Positive Regulation Of Peptidyl-serine Phosphorylation Oncostatin-M-mediated Signaling Pathway Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Positive Regulation Of MAPK Cascade Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Hormone Secretion Positive Regulation Of Inflammatory Response Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Cell Division Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Hematopoietic Stem Cell Differentiation	Skeletal Muscle Contraction Regulation Of Muscle Contraction Transition Between Fast And Slow Fiber Slow-twitch Skeletal Muscle Fiber Contraction Sarcomere Organization Negative Regulation Of Muscle Contraction
Pathways		Interleukin-4 and Interleukin-13 signaling IL-6-type cytokine receptor ligand interactions	Striated Muscle Contraction
Drugs
Diseases			Nemaline myopathy
GWAS		Coronary artery disease ( 29212778 33020668) Delirium ( 29631748) Heel bone mineral density ( 30598549) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494) Inflammatory bowel disease ( 23128233) Myocardial infarction ( 33532862) Nephropathy ( 21399633) Suicidal ideation ( 30145303) Tonsillectomy ( 27941131)	Height ( 31562340)
Interacting Genes		13 interacting genes: APP COL4A1 COL4A2 COL4A3 COL4A4 COL4A5 COL4A6 IL6ST LIFR OSMR S100P TNNT1 ZNF410	69 interacting genes: ARMC8 BLOC1S2 BMPR1B CCDC136 CCDC85B CHD3 CLIP4 DDX5 EEF1G FAF1 FXR2 FYN HAP1 HMGXB4 HSP90AB1 IMMT KAT5 KRT27 KRT40 LARP1 LDOC1 MARS1 MORF4L1 MYOM2 NACAD NAGK NFE2L2 NINL NSG2 OSBP2 OSM PI4KA PLEKHF1 PNMA1 PPFIA1 PRKG1 PSMC5 SBK3 SDCBP2 SEC31A SERPINA4 SH3GL3 SMAD1 SMAD2 SMURF1 SNW1 TBPL1 TFIP11 TGFBR1 TMEM98 TNNC1 TNNI1 TNNI2 TNNI3 TNNT2 TPM1 TPM3 TRA2A TRIM63 TSPYL2 TULP3 UBE2D1 VIM WDCP ZC3H15 ZKSCAN5 ZMYND19 ZNF250 ZNF768
Entrez ID		5008	7138
HPRD ID		01300	01841
Ensembl ID		ENSG00000099985	ENSG00000105048
Uniprot IDs		B5MCX1 P13725	P13805
PDB IDs		1EVS 8V29 8V2A
Enriched GO Terms of Interacting Partners?		Collagen Type IV Trimer Collagen-activated Tyrosine Kinase Receptor Signaling Pathway Extracellular Matrix Structural Constituent Conferring Tensile Strength Collagen-activated Signaling Pathway Collagen Trimer Basement Membrane Extracellular Matrix Structural Constituent Oncostatin-M Receptor Activity Endoplasmic Reticulum Lumen Oncostatin-M-mediated Signaling Pathway Ciliary Neurotrophic Factor Receptor Binding Extracellular Matrix Organization Extracellular Structure Organization Enzyme-linked Receptor Protein Signaling Pathway Extracellular Region Extracellular Matrix Leukemia Inhibitory Factor Receptor Activity Oncostatin-M Receptor Complex Ciliary Neurotrophic Factor Receptor Activity Leukemia Inhibitory Factor Signaling Pathway Cell Surface Receptor Signaling Pathway Cytokine Binding Growth Factor Binding Ciliary Neurotrophic Factor-mediated Signaling Pathway Cytokine Receptor Activity Receptor Complex Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Glomerular Basement Membrane Development Cell Body Transition Metal Ion Binding External Side Of Plasma Membrane Positive Regulation Of Acute Inflammatory Response Integrin Binding Positive Regulation Of Inflammatory Response Signal Transduction Cell Junction Organization Neuromuscular Junction Development Regulation Of Acute Inflammatory Response Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Response To Cytokine Slow-twitch Skeletal Muscle Fiber Contraction Response To Peptide Synapse Organization Regulation Of Cell Population Proliferation Acetylcholine Receptor Activator Activity Lipoprotein Particle	Troponin Complex Cardiac Muscle Contraction Ventricular Cardiac Muscle Tissue Morphogenesis SMAD Binding Muscle System Process Cardiac Troponin Complex Cardiac Muscle Tissue Morphogenesis Muscle Contraction Troponin T Binding Muscle Filament Sliding I-SMAD Binding Muscle Tissue Morphogenesis Actin-myosin Filament Sliding Striated Muscle Contraction Protein Binding Skeletal Muscle Contraction Primary MiRNA Processing Homomeric SMAD Protein Complex Actin-mediated Cell Contraction Contractile Muscle Fiber Regulation Of Hematopoietic Stem Cell Differentiation Tissue Morphogenesis Negative Regulation Of Vascular Associated Smooth Muscle Cell Migration Troponin C Binding Regulation Of Muscle System Process Regulation Of Muscle Contraction Sarcomere Response To Muramyl Dipeptide Regulation Of Primary Metabolic Process Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Troponin I Binding Muscle Thin Filament Tropomyosin Cytosol Actin Filament-based Movement Regulation Of Cell Differentiation Regulation Of Nucleobase-containing Compound Metabolic Process Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Cytoskeleton Organization Transforming Growth Factor Beta Receptor Activity, Type I Disordered Domain Specific Binding Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process R-SMAD Binding Cytoplasm Negative Regulation Of Smooth Muscle Cell Migration Regulation Of Stem Cell Differentiation Calcium-dependent Protein Binding SMAD Protein Complex Trophoblast Cell Migration Transition Between Fast And Slow Fiber Cardiac Myofibril
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