OSM and LIFR

Number of citations of the paper that reports this interaction (PMID 1542794)
119

Data Source:
HPRD (in vitro)

		OSM	LIFR
Gene Name		oncostatin M	leukemia inhibitory factor receptor alpha
Image
Gene Ontology Annotations	Cellular Component	Extracellular Space	Integral Component Of Plasma Membrane Receptor Complex Extracellular Vesicular Exosome
	Molecular Function	Cytokine Activity Oncostatin-M Receptor Binding Growth Factor Activity	Ciliary Neurotrophic Factor Receptor Activity Leukemia Inhibitory Factor Receptor Activity Oncostatin-M Receptor Activity Ciliary Neurotrophic Factor Receptor Binding Growth Factor Binding
	Biological Process	Positive Regulation Of Acute Inflammatory Response Immune Response Multicellular Organismal Development Peripheral Nervous System Development Cell Proliferation Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Response To Heat Positive Regulation Of Peptidyl-serine Phosphorylation Oncostatin-M-mediated Signaling Pathway Regulation Of Growth Tyrosine Phosphorylation Of Stat3 Protein Tyrosine Phosphorylation Of Stat5 Protein Tyrosine Phosphorylation Of Stat1 Protein Positive Regulation Of MAPK Cascade Negative Regulation Of Meiotic Nuclear Division Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Hormone Secretion Behavioral Response To Pain Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Cell Division Positive Regulation Of Apoptotic Signaling Pathway	Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Proliferation Cytokine-mediated Signaling Pathway Response To Cytokine Oncostatin-M-mediated Signaling Pathway Leukemia Inhibitory Factor Signaling Pathway Ciliary Neurotrophic Factor-mediated Signaling Pathway
Pathways
Drugs
Diseases
GWAS		Inflammatory bowel disease ( 23128233) Nephropathy ( 21399633)
Protein-Protein Interactions		11 interactors: APP COL4A1 COL4A2 COL4A3 COL4A4 COL4A5 COL4A6 IL6ST LIFR OSMR TNNT1	12 interactors: CNTF CNTFR CTF1 IL31RA IL6ST LIF MAPK1 OSM PLCG1 POU2F1 PTPN11 PTPN6
Entrez ID		5008	3977
HPRD ID		01300	01048
Ensembl ID		ENSG00000099985	ENSG00000113594
Uniprot IDs		P13725	A8K1Z4 P42702
PDB IDs		1EVS	3E0G
Enriched GO Terms of Interacting Partners?		Collagen Catabolic Process Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Multicellular Organismal Metabolic Process Extracellular Matrix Disassembly Extracellular Matrix Organization Extracellular Structure Organization Oncostatin-M-mediated Signaling Pathway Axon Guidance Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Neuron Projection Morphogenesis Cell Morphogenesis Involved In Differentiation Neuron Projection Development Cell Projection Morphogenesis Cell Part Morphogenesis Movement Of Cell Or Subcellular Component Leukemia Inhibitory Factor Signaling Pathway Generation Of Neurons Neuromuscular Junction Development Neuron Development Neurogenesis Ciliary Neurotrophic Factor-mediated Signaling Pathway Cell Morphogenesis Neuron Differentiation Cell Projection Organization Locomotion Nervous System Development Glomerular Basement Membrane Development Synapse Organization Catabolic Process Cell Development Response To External Stimulus Positive Regulation Of Acute Inflammatory Response Cell Differentiation Anatomical Structure Morphogenesis Glomerulus Development Renal System Development Interleukin-11-mediated Signaling Pathway Regulation Of Acute Inflammatory Response Urogenital System Development Negative Regulation Of Angiogenesis System Development Positive Regulation Of Inflammatory Response Cellular Response To Organic Substance Synaptic Growth At Neuromuscular Junction Interleukin-27-mediated Signaling Pathway Cytokine-mediated Signaling Pathway	Cellular Response To Cytokine Stimulus Response To Cytokine Cytokine-mediated Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Proliferation JAK-STAT Cascade Regulation Of Protein Phosphorylation Regulation Of Cellular Amino Acid Metabolic Process Positive Regulation Of Protein Phosphorylation Leukemia Inhibitory Factor Signaling Pathway Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Positive Regulation Of Signal Transduction Ciliary Neurotrophic Factor-mediated Signaling Pathway Regulation Of Phosphorylation System Development Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Regulation Of Cellular Ketone Metabolic Process Positive Regulation Of Phosphorylation Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Protein Modification Process Cell Surface Receptor Signaling Pathway Regulation Of Phosphorus Metabolic Process Regulation Of Cell Proliferation Multicellular Organismal Development Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Anatomical Structure Development Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Intracellular Signal Transduction Positive Regulation Of JAK-STAT Cascade Positive Regulation Of Protein Metabolic Process Cellular Response To Organic Substance Developmental Process Regulation Of Cellular Protein Metabolic Process Signaling Cell Communication Regulation Of Protein Metabolic Process Regulation Of JAK-STAT Cascade Nervous System Development Cell Differentiation Abortive Mitotic Cell Cycle Regulation Of MAPK Cascade Response To Organic Substance Positive Regulation Of Cellular Metabolic Process Signal Transduction Regulation Of Signal Transduction Regulation Of Immune System Process Organ Development Oncostatin-M-mediated Signaling Pathway
Tagcloud ?		32d absolute alphabeta antiproliferative antiviral consistent detectably express fibrosarcoma ifn ifns interdependence interferons irs jak jak1 jak2 jaks janus kinases lacking largely neither oncostatin phophorylation phosphatidylinositol requirement stat tyk2	box chimeric coexpression consensus constructs contained converges dominant entire gp130 jak lacking mapk maximal maximally mitogen motif polypeptide polypeptides positions putative ras shp2 similarly stimulate stimulation tyk tyr y118f
Tagcloud (Difference) ?		32d absolute alphabeta antiproliferative antiviral consistent detectably express fibrosarcoma ifn ifns interdependence interferons irs jak1 jak2 jaks janus kinases largely neither oncostatin phophorylation phosphatidylinositol requirement stat tyk2	box chimeric coexpression consensus constructs contained converges dominant entire gp130 mapk maximal maximally mitogen motif polypeptide polypeptides positions putative ras shp2 similarly stimulate stimulation tyk tyr y118f
Tagcloud (Intersection) ?		jak lacking