OSM and COL4A6

Number of citations of the paper that reports this interaction (PMID 11711546)
6

Data Source:
HPRD (in vitro)

		OSM	COL4A6
Gene Name		oncostatin M	collagen, type IV, alpha 6
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space	Extracellular Region Collagen Type IV Trimer Endoplasmic Reticulum Lumen
	Molecular Function	Cytokine Activity Oncostatin-M Receptor Binding Growth Factor Activity	Extracellular Matrix Structural Constituent
	Biological Process	Positive Regulation Of Acute Inflammatory Response Immune Response Multicellular Organismal Development Peripheral Nervous System Development Cell Proliferation Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Response To Heat Positive Regulation Of Peptidyl-serine Phosphorylation Oncostatin-M-mediated Signaling Pathway Regulation Of Growth Tyrosine Phosphorylation Of Stat3 Protein Tyrosine Phosphorylation Of Stat5 Protein Tyrosine Phosphorylation Of Stat1 Protein Positive Regulation Of MAPK Cascade Negative Regulation Of Meiotic Nuclear Division Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Hormone Secretion Behavioral Response To Pain Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Cell Division Positive Regulation Of Apoptotic Signaling Pathway	Cell Adhesion Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Catabolic Process
Pathways			Collagen formation Laminin interactions Collagen degradation ECM proteoglycans Anchoring fibril formation Integrin cell surface interactions Non-integrin membrane-ECM interactions Collagen biosynthesis and modifying enzymes Degradation of the extracellular matrix Assembly of collagen fibrils and other multimeric structures
Drugs
Diseases
GWAS		Inflammatory bowel disease ( 23128233) Nephropathy ( 21399633)
Protein-Protein Interactions		11 interactors: APP COL4A1 COL4A2 COL4A3 COL4A4 COL4A5 COL4A6 IL6ST LIFR OSMR TNNT1	10 interactors: APP CD93 DCN FBLN2 FN1 HABP2 MATN2 MMP9 OSM SERPINE2
Entrez ID		5008	1288
HPRD ID		01300	02364
Ensembl ID		ENSG00000099985	ENSG00000197565
Uniprot IDs		P13725	F5H851 Q14031 Q9BS57
PDB IDs		1EVS
Enriched GO Terms of Interacting Partners?		Collagen Catabolic Process Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Multicellular Organismal Metabolic Process Extracellular Matrix Disassembly Extracellular Matrix Organization Extracellular Structure Organization Oncostatin-M-mediated Signaling Pathway Axon Guidance Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Neuron Projection Morphogenesis Cell Morphogenesis Involved In Differentiation Neuron Projection Development Cell Projection Morphogenesis Cell Part Morphogenesis Movement Of Cell Or Subcellular Component Leukemia Inhibitory Factor Signaling Pathway Generation Of Neurons Neuromuscular Junction Development Neuron Development Neurogenesis Ciliary Neurotrophic Factor-mediated Signaling Pathway Cell Morphogenesis Neuron Differentiation Cell Projection Organization Locomotion Nervous System Development Glomerular Basement Membrane Development Synapse Organization Catabolic Process Cell Development Response To External Stimulus Positive Regulation Of Acute Inflammatory Response Cell Differentiation Anatomical Structure Morphogenesis Glomerulus Development Renal System Development Interleukin-11-mediated Signaling Pathway Regulation Of Acute Inflammatory Response Urogenital System Development Negative Regulation Of Angiogenesis System Development Positive Regulation Of Inflammatory Response Cellular Response To Organic Substance Synaptic Growth At Neuromuscular Junction Interleukin-27-mediated Signaling Pathway Cytokine-mediated Signaling Pathway	Extracellular Matrix Organization Extracellular Structure Organization Response To Wounding Extracellular Matrix Disassembly Wound Healing Regulation Of Growth Endodermal Cell Differentiation Nervous System Development Cell Morphogenesis Involved In Differentiation Peptide Cross-linking Anatomical Structure Morphogenesis Mating Generation Of Neurons Endoderm Formation Neurogenesis System Development Platelet Degranulation Seminal Vesicle Epithelium Development Dendrite Regeneration Response To External Stimulus Axon Guidance Negative Regulation Of Transport Regulation Of Peptidase Activity Endoderm Development Blood Coagulation Hemostasis Cell Morphogenesis Negative Regulation Of Ion Transport Response To Abiotic Stimulus Single-organism Behavior Multicellular Organismal Development Mating Plug Formation Synaptic Growth At Neuromuscular Junction Cell Adhesion Anatomical Structure Development Secretion By Cell Immune System Process Response To Stress Axonogenesis Locomotion Collateral Sprouting In Absence Of Injury Tyrosine Phosphorylation Of Stat1 Protein Tyrosine Phosphorylation Of Stat5 Protein Formation Of Primary Germ Layer Axon Development Reproductive Process Regulation Of Body Fluid Levels Dendrite Development Cell Morphogenesis Involved In Neuron Differentiation Behavior
Tagcloud ?		32d absolute alphabeta antiproliferative antiviral consistent detectably express fibrosarcoma ifn ifns interdependence interferons irs jak jak1 jak2 jaks janus kinases lacking largely neither oncostatin phophorylation phosphatidylinositol requirement stat tyk2	aiming alport ats comprising concepts contiguous deletion deletions distally encompassing epidemiology exon exons extending families hereditary leiomyomatosis ligation mapped multicentric multiplex nephropathy oligo portugal proximally rarely segregated spanning
Tagcloud (Difference) ?		32d absolute alphabeta antiproliferative antiviral consistent detectably express fibrosarcoma ifn ifns interdependence interferons irs jak jak1 jak2 jaks janus kinases lacking largely neither oncostatin phophorylation phosphatidylinositol requirement stat tyk2	aiming alport ats comprising concepts contiguous deletion deletions distally encompassing epidemiology exon exons extending families hereditary leiomyomatosis ligation mapped multicentric multiplex nephropathy oligo portugal proximally rarely segregated spanning
Tagcloud (Intersection) ?