OSM and OSMR

Number of citations of the paper that reports this interaction (PMID 8999038)
51

Data Source:
HPRD (in vivo, in vitro)

		OSM	OSMR
Gene Name		oncostatin M	oncostatin M receptor
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space	Oncostatin-M Receptor Complex
	Molecular Function	Cytokine Activity Oncostatin-M Receptor Binding Growth Factor Activity	Oncostatin-M Receptor Activity Growth Factor Binding
	Biological Process	Positive Regulation Of Acute Inflammatory Response Immune Response Multicellular Organismal Development Peripheral Nervous System Development Cell Proliferation Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Response To Heat Positive Regulation Of Peptidyl-serine Phosphorylation Oncostatin-M-mediated Signaling Pathway Regulation Of Growth Tyrosine Phosphorylation Of Stat3 Protein Tyrosine Phosphorylation Of Stat5 Protein Tyrosine Phosphorylation Of Stat1 Protein Positive Regulation Of MAPK Cascade Negative Regulation Of Meiotic Nuclear Division Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Hormone Secretion Behavioral Response To Pain Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Cell Division Positive Regulation Of Apoptotic Signaling Pathway	Positive Regulation Of Acute Inflammatory Response Positive Regulation Of Cell Proliferation Response To Cytokine Oncostatin-M-mediated Signaling Pathway
Pathways
Drugs
Diseases
GWAS		Inflammatory bowel disease ( 23128233) Nephropathy ( 21399633)	Obesity-related traits ( 23251661)
Protein-Protein Interactions		11 interactors: APP COL4A1 COL4A2 COL4A3 COL4A4 COL4A5 COL4A6 IL6ST LIFR OSMR TNNT1	5 interactors: GAPDH IL6ST JAK1 JAK2 OSM
Entrez ID		5008	9180
HPRD ID		01300	03446
Ensembl ID		ENSG00000099985	ENSG00000145623
Uniprot IDs		P13725	Q99650
PDB IDs		1EVS
Enriched GO Terms of Interacting Partners?		Collagen Catabolic Process Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Multicellular Organismal Metabolic Process Extracellular Matrix Disassembly Extracellular Matrix Organization Extracellular Structure Organization Oncostatin-M-mediated Signaling Pathway Axon Guidance Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Neuron Projection Morphogenesis Cell Morphogenesis Involved In Differentiation Neuron Projection Development Cell Projection Morphogenesis Cell Part Morphogenesis Movement Of Cell Or Subcellular Component Leukemia Inhibitory Factor Signaling Pathway Generation Of Neurons Neuromuscular Junction Development Neuron Development Neurogenesis Ciliary Neurotrophic Factor-mediated Signaling Pathway Cell Morphogenesis Neuron Differentiation Cell Projection Organization Locomotion Nervous System Development Glomerular Basement Membrane Development Synapse Organization Catabolic Process Cell Development Response To External Stimulus Positive Regulation Of Acute Inflammatory Response Cell Differentiation Anatomical Structure Morphogenesis Glomerulus Development Renal System Development Interleukin-11-mediated Signaling Pathway Regulation Of Acute Inflammatory Response Urogenital System Development Negative Regulation Of Angiogenesis System Development Positive Regulation Of Inflammatory Response Cellular Response To Organic Substance Synaptic Growth At Neuromuscular Junction Interleukin-27-mediated Signaling Pathway Cytokine-mediated Signaling Pathway	Cellular Response To Cytokine Stimulus Response To Cytokine Tyrosine Phosphorylation Of Stat1 Protein Tyrosine Phosphorylation Of Stat5 Protein Oncostatin-M-mediated Signaling Pathway Tyrosine Phosphorylation Of Stat3 Protein Positive Regulation Of Inflammatory Response Cytokine-mediated Signaling Pathway Regulation Of Cytokine-mediated Signaling Pathway Tyrosine Phosphorylation Of STAT Protein Cellular Response To Interferon-gamma Positive Regulation Of Peptidyl-tyrosine Phosphorylation Cellular Response To Organic Substance Response To Interferon-gamma Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Interferon-gamma-mediated Signaling Pathway Regulation Of Response To Interferon-gamma Positive Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Positive Regulation Of Acute Inflammatory Response Peptidyl-amino Acid Modification Response To Organic Substance Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Regulation Of Inflammatory Response Peptidyl-tyrosine Phosphorylation Peptidyl-tyrosine Autophosphorylation Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Immune Response Regulation Of Cellular Amino Acid Metabolic Process JAK-STAT Cascade Response To Antibiotic Positive Regulation Of JAK-STAT Cascade Regulation Of Cell Proliferation Regulation Of Cellular Ketone Metabolic Process Regulation Of Acute Inflammatory Response Regulation Of JAK-STAT Cascade Host Programmed Cell Death Induced By Symbiont Interleukin-11-mediated Signaling Pathway Peptidyl-cysteine S-trans-nitrosylation Histone H3-Y41 Phosphorylation Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Phosphorylation Interferon-gamma-mediated Signaling Pathway Immune System Process Regulation Of Protein Metabolic Process Innate Immune Response Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Proliferation Interleukin-27-mediated Signaling Pathway Mineralocorticoid Receptor Signaling Pathway Positive Regulation Of Phosphorylation
Tagcloud ?		32d absolute alphabeta antiproliferative antiviral consistent detectably express fibrosarcoma ifn ifns interdependence interferons irs jak jak1 jak2 jaks janus kinases lacking largely neither oncostatin phophorylation phosphatidylinositol requirement stat tyk2	apart auuua closed dependently dispensable ehlting erk1 fr180204 hepatocytes integrates intercellular involves knock mek1 mk2 osmrbeta p38mapk pentameric proximity sb203580 sensing socs socs3 stabilization transcript u0126 unexpectedly utr
Tagcloud (Difference) ?		32d absolute alphabeta antiproliferative antiviral consistent detectably express fibrosarcoma ifn ifns interdependence interferons irs jak jak1 jak2 jaks janus kinases lacking largely neither oncostatin phophorylation phosphatidylinositol requirement stat tyk2	apart auuua closed dependently dispensable ehlting erk1 fr180204 hepatocytes integrates intercellular involves knock mek1 mk2 osmrbeta p38mapk pentameric proximity sb203580 sensing socs socs3 stabilization transcript u0126 unexpectedly utr
Tagcloud (Intersection) ?