NUCB2 and GADD45A

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (affinity chromatography technology, two hybrid)

		NUCB2	GADD45A
Gene Name		nucleobindin 2	growth arrest and DNA-damage-inducible, alpha
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Nuclear Envelope Endoplasmic Reticulum Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Cytosol Plasma Membrane Extracellular Vesicular Exosome	Nucleus Cytoplasm
	Molecular Function	DNA Binding Calcium Ion Binding Protein Binding	Core Promoter Binding Protein Binding
	Biological Process		Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Activation Of MAPKKK Activity DNA Repair Negative Regulation Of Protein Kinase Activity Apoptotic Process Cell Cycle Arrest Centrosome Cycle Signal Transduction In Response To DNA Damage Positive Regulation Of Apoptotic Process Positive Regulation Of JNK Cascade Cellular Response To Mechanical Stimulus Cellular Response To Ionizing Radiation Positive Regulation Of P38MAPK Cascade Positive Regulation Of Reactive Oxygen Species Metabolic Process
Pathways
Drugs
Diseases
GWAS		Height ( 20881960)
Protein-Protein Interactions		8 interactors: GADD45A GNAI3 GNAS NDN NR1I2 SMARCD1 STAR XPO1	65 interactors: ADAP1 ASCC2 AURKA BAG6 C14orf1 CCNB1 CDK1 CDK11A CDKN1A CENPB CHD3 CLEC3B DCTN2 DNAJC13 EEF1A1 EEF1G FAM83D FAS FBN3 FTL GADD45GIP1 GAPDH GBP2 GNB2 HIST1H1A HIST1H2AL HIST2H2BE HIST3H3 HIST4H4 IGHM IGSF21 JMJD1C KHSRP LMO4 MAP3K4 MAPK14 MASP1 MDM2 MICAL1 MIDN MPP1 NPM1 NRBP1 NUCB2 PCNA PFKFB4 PPARA PSMC3 PTN PTPRK QARS RAI1 RBPJ RPS2 RXRA SH3GLB1 SPTBN4 SYNE4 TLE1 TP53 UBE2D1 UBR1 VIM ZHX1 ZNF135
Entrez ID		4925	1647
HPRD ID		09726	00528
Ensembl ID		ENSG00000070081	ENSG00000116717
Uniprot IDs		E9PKG6 P80303	A5JUZ3 P24522
PDB IDs			2KG4
Enriched GO Terms of Interacting Partners?		Response To Drug Cellular Response To Catecholamine Stimulus Genetic Imprinting Cyclic Purine Nucleotide Metabolic Process Regulation Of Metabolic Process Cyclic Nucleotide Biosynthetic Process Cellular Response To Organic Substance Regulation Of Adenylate Cyclase Activity Signal Transduction Regulation Of Cyclase Activity Cellular Response To Organic Cyclic Compound Signaling Cyclic Nucleotide Metabolic Process Cellular Response To Lipid Cell Communication Drug Export Post-embryonic Body Morphogenesis Cellular Response To Luteinizing Hormone Stimulus Circadian Sleep/wake Cycle, REM Sleep Regulation Of CAMP Biosynthetic Process Regulation Of CAMP Metabolic Process Response To Organic Substance Response To Luteinizing Hormone Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Cellular Response To Growth Factor Stimulus Cellular Response To Hormone Stimulus Cellular Response To Stimulus Response To Growth Factor Xenobiotic Metabolic Process Cellular Response To Xenobiotic Stimulus Post-embryonic Development Ribosomal Small Subunit Export From Nucleus Insecticide Metabolic Process Response To Ionizing Radiation G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Response To Xenobiotic Stimulus Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Purine Nucleotide Biosynthetic Process Regulation Of Gene Expression Ribose Phosphate Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Cellular Response To Steroid Hormone Stimulus Cell Surface Receptor Signaling Pathway Circadian Sleep/wake Cycle Process Fractalkine Metabolic Process Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Platelet Activation Xenobiotic Transport Regulation Of Gene Expression, Epigenetic	Regulation Of Metabolic Process Cell Cycle Cell Cycle Process Regulation Of Gene Expression Mitotic Cell Cycle Mitotic Cell Cycle Process Cellular Response To Organic Substance Regulation Of Protein Metabolic Process Organelle Organization DNA Packaging DNA Conformation Change Negative Regulation Of Cellular Metabolic Process Apoptotic Process Programmed Cell Death Regulation Of Cellular Protein Metabolic Process Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Chromosome Organization Cell Aging Protein Complex Assembly Chromatin Organization Negative Regulation Of Cell Cycle Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Cell Death Death Positive Regulation Of Protein Metabolic Process Cell Cycle Checkpoint Positive Regulation Of Cellular Protein Catabolic Process Response To Organic Substance DNA Damage Checkpoint Chromatin Assembly Or Disassembly Stress-induced Premature Senescence Immune Response Mitotic Cell Cycle Checkpoint Positive Regulation Of Cellular Protein Metabolic Process Signal Transduction In Response To DNA Damage Negative Regulation Of Gene Expression Mitotic DNA Damage Checkpoint Immune System Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Negative Regulation Of Cell Death Positive Regulation Of Metabolic Process Innate Immune Response Mitotic DNA Integrity Checkpoint Response To Toxic Substance Positive Regulation Of Cell Cycle Regulation Of Nitrogen Compound Metabolic Process Regulation Of Mitotic Cell Cycle Positive Regulation Of Proteolysis Cellular Response To Oxygen Levels
Tagcloud ?		animal birth blot catch diets difference divided feeding gastric ghrelin groups growth immediately interact intrauterine iugr mucosa nesfatin newborn nutritional observation pregnancy produce rats retardation significance starting weaning whole	2h5 accompanies anova dynactin gtf2h5 invites keuls macaques malfunctioning nbn1 ndd ndds newman ovx perimenopausal presenilin1 proteosome psen1 rad23a raphe scna serotonin speculation subserving symptomology ube2d3 ube3a ubea5 ubiquinase
Tagcloud (Difference) ?		animal birth blot catch diets difference divided feeding gastric ghrelin groups growth immediately interact intrauterine iugr mucosa nesfatin newborn nutritional observation pregnancy produce rats retardation significance starting weaning whole	2h5 accompanies anova dynactin gtf2h5 invites keuls macaques malfunctioning nbn1 ndd ndds newman ovx perimenopausal presenilin1 proteosome psen1 rad23a raphe scna serotonin speculation subserving symptomology ube2d3 ube3a ubea5 ubiquinase
Tagcloud (Intersection) ?