NUCB2 and GNAS

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		NUCB2	GNAS
Gene Name		nucleobindin 2	GNAS complex locus
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Nuclear Envelope Endoplasmic Reticulum Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Cytosol Plasma Membrane Extracellular Vesicular Exosome	Ruffle Extracellular Region Nucleus Cytoplasm Cytosol Heterotrimeric G-protein Complex Plasma Membrane Membrane Transport Vesicle Dendrite Intrinsic Component Of Membrane Trans-Golgi Network Membrane Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	DNA Binding Calcium Ion Binding Protein Binding	Molecular_function GTPase Activity Adenylate Cyclase Activity Signal Transducer Activity Insulin-like Growth Factor Receptor Binding Protein Binding GTP Binding G-protein Beta/gamma-subunit Complex Binding Beta-2 Adrenergic Receptor Binding D1 Dopamine Receptor Binding Mu-type Opioid Receptor Binding Ionotropic Glutamate Receptor Binding Metal Ion Binding Corticotropin-releasing Hormone Receptor 1 Binding
	Biological Process		Tissue Homeostasis Endochondral Ossification Renal Water Homeostasis Energy Reserve Metabolic Process CAMP Biosynthetic Process DNA Methylation Water Transport Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Female Pregnancy Blood Coagulation Sensory Perception Of Chemical Stimulus Sensory Perception Of Smell Protein Secretion Positive Regulation Of CAMP Biosynthetic Process Positive Regulation Of Ras GTPase Activity Embryonic Hindlimb Morphogenesis Multicellular Organism Growth Negative Regulation Of Multicellular Organism Growth Post-embryonic Body Morphogenesis Response To Drug Positive Regulation Of CAMP-mediated Signaling Small Molecule Metabolic Process Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Osteoclast Differentiation Intracellular Transport Developmental Growth Embryonic Cranial Skeleton Morphogenesis Regulation Of Insulin Secretion Cognition Cartilage Development Transmembrane Transport Bone Development Hair Follicle Placode Formation Platelet Aggregation Response To Parathyroid Hormone Cellular Response To Glucagon Stimulus Cellular Response To Prostaglandin E Stimulus Genetic Imprinting Cellular Response To Catecholamine Stimulus Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway
Pathways			Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Integration of energy metabolism Hedgehog 'off' state G alpha (s) signalling events Glucagon-type ligand receptors Metabolic disorders of biological oxidation enzymes G alpha (z) signalling events G alpha (i) signalling events Class B/2 (Secretin family receptors) Glucagon signaling in metabolic regulation Prostacyclin signalling through prostacyclin receptor PKA activation in glucagon signalling Vasopressin regulates renal water homeostasis via Aquaporins Regulation of insulin secretion GPCR ligand binding Aquaporin-mediated transport GPCR downstream signaling Platelet homeostasis Signaling by Hedgehog
Drugs
Diseases
GWAS		Height ( 20881960)	Blood pressure ( 21909110) Diastolic blood pressure ( 21909115) DNA methylation (variation) ( 23725790) Hypertension ( 21909115) Renal function-related traits (BUN) ( 22797727) Response to diuretic therapy in hypertension ( 23753411) Systolic blood pressure ( 21909115)
Protein-Protein Interactions		8 interactors: GADD45A GNAI3 GNAS NDN NR1I2 SMARCD1 STAR XPO1	31 interactors: ADCY2 ADCY5 ADCY6 ADORA1 ADRB2 ADRB3 AVPR2 AXIN1 CALM1 CAV3 CRHR1 GCGR GNB1 GNGT1 HTR6 LHB LHCGR NUCB1 NUCB2 OPTN PANX1 PTGDR PTGIR RGS2 RIC8A RIC8B SNX13 TBXA2R TSHR TTC1 VIPR1
Entrez ID		4925	2778
HPRD ID		09726	00761
Ensembl ID		ENSG00000070081	ENSG00000087460
Uniprot IDs		E9PKG6 P80303	O95467 P63092 P84996 Q5JWF2
PDB IDs
Enriched GO Terms of Interacting Partners?		Response To Drug Cellular Response To Catecholamine Stimulus Genetic Imprinting Cyclic Purine Nucleotide Metabolic Process Regulation Of Metabolic Process Cyclic Nucleotide Biosynthetic Process Cellular Response To Organic Substance Regulation Of Adenylate Cyclase Activity Signal Transduction Regulation Of Cyclase Activity Cellular Response To Organic Cyclic Compound Signaling Cyclic Nucleotide Metabolic Process Cellular Response To Lipid Cell Communication Drug Export Post-embryonic Body Morphogenesis Cellular Response To Luteinizing Hormone Stimulus Circadian Sleep/wake Cycle, REM Sleep Regulation Of CAMP Biosynthetic Process Regulation Of CAMP Metabolic Process Response To Organic Substance Response To Luteinizing Hormone Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Cellular Response To Growth Factor Stimulus Cellular Response To Hormone Stimulus Cellular Response To Stimulus Response To Growth Factor Xenobiotic Metabolic Process Cellular Response To Xenobiotic Stimulus Post-embryonic Development Ribosomal Small Subunit Export From Nucleus Insecticide Metabolic Process Response To Ionizing Radiation G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Response To Xenobiotic Stimulus Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Purine Nucleotide Biosynthetic Process Regulation Of Gene Expression Ribose Phosphate Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Cellular Response To Steroid Hormone Stimulus Cell Surface Receptor Signaling Pathway Circadian Sleep/wake Cycle Process Fractalkine Metabolic Process Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Platelet Activation Xenobiotic Transport Regulation Of Gene Expression, Epigenetic	G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Catalytic Activity Cell Surface Receptor Signaling Pathway Positive Regulation Of CAMP Biosynthetic Process Cell-cell Signaling Activation Of Adenylate Cyclase Activity Regulation Of Catalytic Activity Positive Regulation Of CAMP Metabolic Process Positive Regulation Of Adenylate Cyclase Activity Signal Transduction Positive Regulation Of Cyclic Nucleotide Metabolic Process Regulation Of CAMP Biosynthetic Process Positive Regulation Of Lyase Activity Regulation Of CAMP Metabolic Process Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Signaling Cell Communication Regulation Of Adenylate Cyclase Activity Regulation Of Cyclase Activity Energy Reserve Metabolic Process Regulation Of Phosphorus Metabolic Process Positive Regulation Of Metabolic Process Cellular Response To Glucagon Stimulus Synaptic Transmission Cellular Response To Stimulus Positive Regulation Of Hydrolase Activity Response To Stress Response To Glucagon Response To Hormone Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Response To Stimulus Regulation Of Body Fluid Levels Cellular Response To Hormone Stimulus Homeostatic Process Regulation Of Muscle Contraction Response To Organic Substance Renal Water Homeostasis Energy Derivation By Oxidation Of Organic Compounds Regulation Of Cellular Process Regulation Of Phospholipase Activity Regulation Of Blood Pressure Blood Circulation Regulation Of Signaling Vasodilation Negative Regulation Of Ion Transport Renal System Process Regulation Of Protein Kinase Activity
Tagcloud ?		animal birth blot catch diets difference divided feeding gastric ghrelin groups growth immediately interact intrauterine iugr mucosa nesfatin newborn nutritional observation pregnancy produce rats retardation significance starting weaning whole	accompanying addressed adenylyl allergic bias camp cd11c cyclases dc dendritic encodes focusing galphai galphas gap gnasdeltacd11c gtp heterotrimeric immunopathologies imply inductive pka polarization prominent provoke th th2 turn yields
Tagcloud (Difference) ?		animal birth blot catch diets difference divided feeding gastric ghrelin groups growth immediately interact intrauterine iugr mucosa nesfatin newborn nutritional observation pregnancy produce rats retardation significance starting weaning whole	accompanying addressed adenylyl allergic bias camp cd11c cyclases dc dendritic encodes focusing galphai galphas gap gnasdeltacd11c gtp heterotrimeric immunopathologies imply inductive pka polarization prominent provoke th th2 turn yields
Tagcloud (Intersection) ?