NUCB2

Description		nucleobindin 2
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Nuclear Envelope Nuclear Outer Membrane Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Cytosol Plasma Membrane Endomembrane System Membrane Extracellular Exosome
	Molecular Function	G-protein Alpha-subunit Binding DNA Binding Guanyl-nucleotide Exchange Factor Activity Calcium Ion Binding Protein Binding Metal Ion Binding
	Biological Process	Small GTPase-mediated Signal Transduction
Pathways
Drugs		Calcium citrate Calcium Phosphate Calcium phosphate dihydrate
Diseases
GWAS		Body mass index ( 26426971) Height ( 20881960) Mean platelet volume ( 32888494) Pulse pressure ( 27841878) Systolic blood pressure ( 27841878 28739976) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for body mass index ( 28448500 34021172) Youthful appearance (self-reported) ( 32339537)
Novel Interacting Genes		2 novel interacting genes: FURIN NFRKB
Interacting Genes		12 interacting genes: ARL13B ASPH FFAR2 GADD45A GNAI3 GNAS NDN NR1I2 SLC7A1 SMARCD1 STAR XPO1
Entrez ID		4925
HPRD ID		09726
Ensembl ID		ENSG00000070081
Uniprot IDs		P80303 Q2L696
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Metabolic Process Regulation Of Metabolic Process Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding Regulation Of Protein Transport Heterotrimeric G-protein Complex Negative Regulation Of Inflammatory Response To Antigenic Stimulus Cellular Response To Lipid Cellular Response To Fatty Acid Regulation Of Establishment Of Protein Localization Negative Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein Negative Regulation Of Nerve Growth Factor Production Dibasic Protein Processing Zymogen Inhibition Regulation Of Multicellular Organismal Process Peptidyl-aspartic Acid 3-dioxygenase Activity Promoter-specific Chromatin Binding Mu-type Opioid Receptor Binding Positive Regulation Of Acute Inflammatory Response To Non-antigenic Stimulus Response To Fatty Acid Golgi Apparatus Subcompartment Regulation Of Nerve Growth Factor Production Negative Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Nerve Growth Factor Production Negative Regulation Of Neurotrophin Production Lysine Transport L-histidine Import Across Plasma Membrane Cellular Response To Triglyceride
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