DDR2 and SHC1

Number of citations of the paper that reports this interaction (PubMedID 11884411)
0

Data Source:
HPRD (in vivo, two hybrid)

		DDR2	SHC1
Description		discoidin domain receptor tyrosine kinase 2	SHC adaptor protein 1
Image
GO Annotations	Cellular Component	Plasma Membrane Focal Adhesion Actin Cytoskeleton Membrane Apical Plasma Membrane Receptor Complex	Cytoplasm Mitochondrion Mitochondrial Matrix Cytosol Plasma Membrane Focal Adhesion Anchoring Junction Shc-EGFR Complex
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Binding Collagen Binding ATP Binding Kinase Activity Transferase Activity Protein Tyrosine Kinase Collagen Receptor Activity	Phosphotyrosine Residue Binding Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Epidermal Growth Factor Receptor Binding Insulin Receptor Binding Insulin-like Growth Factor Receptor Binding Neurotrophin TRKA Receptor Binding Protein Binding Phospholipid Binding Receptor Tyrosine Kinase Binding Ephrin Receptor Binding Epidermal Growth Factor Binding
	Biological Process	Ossification Endochondral Bone Growth Cell Adhesion Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Cell Population Proliferation Regulation Of Extracellular Matrix Disassembly Positive Regulation Of Fibroblast Migration Positive Regulation Of Neuron Projection Development Peptidyl-tyrosine Phosphorylation Collagen Fibril Organization Regulation Of Bone Mineralization Biomineral Tissue Development Positive Regulation Of Collagen Biosynthetic Process Regulation Of Tissue Remodeling Chondrocyte Proliferation Response To Muscle Stretch Collagen-activated Tyrosine Kinase Receptor Signaling Pathway Negative Regulation Of Apoptotic Process Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Protein Kinase Activity Protein Autophosphorylation Positive Regulation Of Fibroblast Proliferation Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Hypoxia Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Extracellular Matrix Disassembly Positive Regulation Of Wound Healing Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death Cellular Response To Angiotensin Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration Positive Regulation Of Hepatic Stellate Cell Proliferation Positive Regulation Of Hepatic Stellate Cell Activation	Angiogenesis Epidermal Growth Factor Receptor Signaling Pathway Heart Development Positive Regulation Of Cell Population Proliferation Insulin Receptor Signaling Pathway Negative Regulation Of Angiogenesis Actin Cytoskeleton Organization Intracellular Signal Transduction Regulation Of Cell Population Proliferation Defense Response To Bacterium Negative Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Growth Factor Stimulus Positive Regulation Of Cell Proliferation In Bone Marrow Regulation Of Superoxide Metabolic Process Cell-cell Adhesion
Pathways		Non-integrin membrane-ECM interactions	Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants SHC1 events in ERBB2 signaling SHC1 events in ERBB2 signaling SHC1 events in ERBB4 signaling Signalling to RAS Signalling to RAS SHC1 events in EGFR signaling Tie2 Signaling Integrin signaling XBP1(S) activates chaperone genes Interleukin-3, Interleukin-5 and GM-CSF signaling Constitutive Signaling by EGFRvIII RAF/MAP kinase cascade Signal attenuation Insulin receptor signalling cascade Insulin receptor signalling cascade RET signaling Interleukin-15 signaling Interleukin-15 signaling Interleukin-2 signaling Erythropoietin activates RAS Erythropoietin activates RAS Interleukin receptor SHC signaling Constitutive Signaling by Overexpressed ERBB2 Signaling by ERBB2 KD Mutants Signaling by ERBB2 ECD mutants Signaling by ERBB2 TMD/JMD mutants Signaling by CSF3 (G-CSF) Signaling by CSF3 (G-CSF) Signaling by CSF1 (M-CSF) in myeloid cells
Drugs		Imatinib Regorafenib Fostamatinib
Diseases		Spondylometaepiphyseal dysplasia, short limb-hand type; Spondylometaepiphyseal dysplasia, short limb-abnormal calcification type
GWAS		Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Dupuytren's disease ( 28886342) Glaucoma (primary open-angle) ( 33627673) Height ( 31562340)	Bipolar disorder ( 31043756) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Eosinophil count ( 29403010) Hemoglobin levels ( 32327693) Inflammatory bowel disease ( 27569725) Prostate cancer ( 23535732) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		4 interacting genes: COL1A1 COL3A1 SHC1 SRC	144 interacting genes: ALK AP2A1 AP2A2 APP AR AXL BCL3 BCR BUB1 C11orf58 CALCOCO2 CALD1 CBL CBLB CBLC CD22 CD247 CD3E CD81 CDH5 CEACAM1 CFTR CRK CRKL CSF1R CSF2RB CSF3R CSK DAG1 DDR1 DDR2 DOK1 DUSP23 EGFR EPHA2 EPOR EPS8 ERBB2 ERBB3 ERBB4 ESR1 FAM118B FBXW7 FCGR2A FCGR3A FGFR1 FGFR2 FLT1 FLT4 FYN GAB1 GAB2 GEMIN7 GH1 GHR GRAP GRAP2 GRB2 GRB7 HMOX2 IGF1R IL2 IL2RB IL2RG IL4R IL6ST ILK INPP5D INPPL1 INSR IRS1 IRS2 ITGB3 ITGB4 JAK2 KDR KIT KRT18 LCK LCP2 LRP1 LTK LYN MAP4K1 MAPK1 MAPK14 MAPK6 MAPK8 MAPKAPK2 MET MME MPL MRPL44 MST1R NGFR NPM1 NTRK1 NTRK2 NTRK3 NUDT21 OSGEP PAG1 PAK1 PDGFRB PIK3C2B PIK3R1 PIK3R2 PLCG1 PLCG2 PLPP3 PLSCR1 PPP2R5A PRKCA PRKCD PRKRA PTK2 PTK2B PTPN11 PTPN12 PTPN2 PTPN6 RAPGEF1 RASA1 RB1 RET SH2B2 SHCBP1 SMAD4 SOS1 SOS2 SP1 SRC STAT5A STAT5B SUV39H2 SYK TEC TEK TPR TRIM15 UBASH3B VAV1 VAV3 ZAP70
Entrez ID		4921	6464
HPRD ID		01868	02780
Ensembl ID		ENSG00000162733	ENSG00000160691
Uniprot IDs		Q16832	P29353
PDB IDs		2WUH 2Z4F 6FER 7AZB	1MIL 1N3H 1OY2 1QG1 1SHC 1TCE 2L1C 4JMH 4XWX 5CZI 6DM4
Enriched GO Terms of Interacting Partners?		Fibrillar Collagen Trimer Platelet-derived Growth Factor Binding Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Signal Transduction Ephrin Receptor Binding Positive Regulation Of Cell Communication Extracellular Matrix Structural Constituent Conferring Tensile Strength Positive Regulation Of Signaling Cellular Response To Growth Factor Stimulus Response To Peptide Hormone Response To Growth Factor Skin Development Collagen Fibril Organization Negative Regulation Of Cell-substrate Adhesion Cellular Response To Transforming Growth Factor Beta Stimulus Epidermal Growth Factor Receptor Signaling Pathway Platelet Activation Response To Transforming Growth Factor Beta Positive Regulation Of Small GTPase Mediated Signal Transduction Cellular Response To Vitamin E Collagen Trimer Cellular Response To Amino Acid Stimulus Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Collagen Type III Trimer ERBB Signaling Pathway Cartilage Development Response To Amino Acid Collagen Type I Trimer Response To Peptide Protease Binding Positive Regulation Of Canonical Wnt Signaling Pathway Animal Organ Morphogenesis Response To Hydrogen Peroxide Response To Cytokine Cellular Response To Fluoride Animal Organ Development Extracellular Matrix Structural Constituent Transforming Growth Factor Beta Receptor Signaling Pathway Integrin-mediated Signaling Pathway Negative Regulation Of Glycine Import Across Plasma Membrane Regulation Of Heart Rate Shc-EGFR Complex Oligosaccharyl Transferase Activity Regulation Of Signal Transduction Response To Hormone Response To Stress Positive Regulation Of Wnt Signaling Pathway Negative Regulation Of Dopamine Receptor Signaling Pathway Positive Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Blood Vessel Development	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Cell Surface Receptor Signaling Pathway Protein Tyrosine Kinase Activity Signal Transduction Regulation Of Intracellular Signal Transduction Regulation Of MAPK Cascade Transmembrane Receptor Protein Tyrosine Kinase Activity Regulation Of Signal Transduction Peptidyl-tyrosine Phosphorylation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Protein Kinase Activity Receptor Complex Regulation Of Cell Population Proliferation Positive Regulation Of Intracellular Signal Transduction Regulation Of Signaling Regulation Of Cell Communication Kinase Activity Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Cell Population Proliferation Positive Regulation Of Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Multicellular Organismal Process Plasma Membrane Positive Regulation Of MAPK Cascade Protein Phosphorylation Positive Regulation Of Multicellular Organismal Process Regulation Of Immune System Process Phosphorylation Phosphotyrosine Residue Binding Intracellular Signal Transduction Regulation Of Developmental Process Protein Autophosphorylation Immune System Process Regulation Of Immune Response Regulation Of Programmed Cell Death Regulation Of Cell Adhesion Intracellular Signaling Cassette Response To Growth Factor Cell Activation Cytokine-mediated Signaling Pathway Positive Regulation Of Immune System Process Cell Migration Regulation Of Apoptotic Process Positive Regulation Of Cell Migration Regulation Of Cell Activation Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Developmental Process Positive Regulation Of Cell Motility
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