DDR2 and STT3B

Number of citations: 105 (PubMedID 35384245)
Data Source: BioGRID (affinity chromatography technology)

		DDR2	STT3B
Name		discoidin domain receptor tyrosine kinase 2	STT3 oligosaccharyltransferase complex catalytic subunit B
Structure
GO Annotations	Cellular Component	Plasma Membrane Focal Adhesion Actin Cytoskeleton Membrane Apical Plasma Membrane Receptor Complex	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Oligosaccharyltransferase Complex Membrane Protein-containing Complex Oligosaccharyltransferase Complex B
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Binding Collagen Binding ATP Binding Kinase Activity Transferase Activity Protein Tyrosine Kinase Collagen Receptor Activity	Oligosaccharyl Transferase Activity Dolichyl-diphosphooligosaccharide-protein Glycotransferase Activity Protein Binding Transferase Activity Glycosyltransferase Activity Metal Ion Binding
	Biological Process	Ossification Endochondral Bone Growth Cell Adhesion Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Cell Population Proliferation Regulation Of Extracellular Matrix Disassembly Positive Regulation Of Fibroblast Migration Positive Regulation Of Neuron Projection Development Peptidyl-tyrosine Phosphorylation Collagen Fibril Organization Regulation Of Bone Mineralization Biomineral Tissue Development Positive Regulation Of Collagen Biosynthetic Process Regulation Of Tissue Remodeling Chondrocyte Proliferation Response To Muscle Stretch Collagen-activated Tyrosine Kinase Receptor Signaling Pathway Negative Regulation Of Apoptotic Process Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Protein Kinase Activity Protein Autophosphorylation Positive Regulation Of Fibroblast Proliferation Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Hypoxia Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Extracellular Matrix Disassembly Positive Regulation Of Wound Healing Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death Cellular Response To Angiotensin Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration Positive Regulation Of Hepatic Stellate Cell Proliferation Positive Regulation Of Hepatic Stellate Cell Activation	Protein Glycosylation Protein N-linked Glycosylation Glycoprotein Catabolic Process Response To Unfolded Protein Protein N-linked Glycosylation Via Asparagine ERAD Pathway Post-translational Protein Modification
Pathways		Non-integrin membrane-ECM interactions	Asparagine N-linked glycosylation Maturation of spike protein Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition PD-L1(CD274) glycosylation and translocation to plasma membrane
Drugs		Imatinib Regorafenib Fostamatinib	None
Diseases		Spondylometaepiphyseal dysplasia, short limb-hand type; Spondylometaepiphyseal dysplasia, short limb-abnormal calcification type	None
GWAS		Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653 ) Dupuytren's disease ( 28886342 ) Glaucoma (primary open-angle) ( 33627673 ) Height ( 31562340 )	3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30796134 ) Diabetic retinopathy in type 2 diabetes ( 33607655 ) Periodontal disease-related phenotype (Socransky) ( 24347629 ) Urate levels ( 31578528 )
Interacting Genes		4 interacting genes: COL1A1 COL3A1 SHC1 SRC	2 interacting genes: FILNC1 INCA1
Entrez ID		4921	201595
HPRD ID		01868	12268
Ensembl ID		ENSG00000162733	ENSG00000163527
Uniprot IDs		Q16832	Q8TCJ2
PDB IDs		2WUH 2Z4F 6FER 7AZB	6S7T
GO Terms Enriched among Interactors		Fibrillar Collagen Trimer Platelet-derived Growth Factor Binding Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Signal Transduction Ephrin Receptor Binding Positive Regulation Of Cell Communication Extracellular Matrix Structural Constituent Conferring Tensile Strength Positive Regulation Of Signaling Cellular Response To Growth Factor Stimulus Response To Peptide Hormone Response To Growth Factor Skin Development Collagen Fibril Organization Negative Regulation Of Cell-substrate Adhesion Cellular Response To Transforming Growth Factor Beta Stimulus Epidermal Growth Factor Receptor Signaling Pathway Platelet Activation Response To Transforming Growth Factor Beta Positive Regulation Of Small GTPase Mediated Signal Transduction Cellular Response To Vitamin E Collagen Trimer Cellular Response To Amino Acid Stimulus Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Collagen Type III Trimer ERBB Signaling Pathway Cartilage Development Response To Amino Acid Collagen Type I Trimer Response To Peptide Protease Binding Positive Regulation Of Canonical Wnt Signaling Pathway Animal Organ Morphogenesis Response To Hydrogen Peroxide Response To Cytokine Cellular Response To Fluoride Animal Organ Development Extracellular Matrix Structural Constituent Transforming Growth Factor Beta Receptor Signaling Pathway Integrin-mediated Signaling Pathway Negative Regulation Of Glycine Import Across Plasma Membrane Regulation Of Heart Rate Shc-EGFR Complex Oligosaccharyl Transferase Activity Regulation Of Signal Transduction Response To Hormone Response To Stress Positive Regulation Of Wnt Signaling Pathway Negative Regulation Of Dopamine Receptor Signaling Pathway Positive Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Blood Vessel Development	Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Protein Catabolic Process Regulation Of Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Sterol 14-demethylase Activity Cholesterol Biosynthetic Process Via 24,25-dihydrolanosterol Xylulose Catabolic Process D-xylulokinase Activity Aspartate Family Amino Acid Metabolic Process Glycine N-methyltransferase Activity Methionine-glyoxylate Transaminase Activity Glycine:2-oxoglutarate Aminotransferase Activity 2-aminoadipate Transaminase Activity Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Hepatic Stellate Cell Proliferation Protein Tyrosine Kinase Collagen Receptor Activity RNA Strand-exchange Activity Eukaryotic Translation Initiation Factor 4F Complex Assembly Xylulose Metabolic Process Sarcosine Metabolic Process S-adenosylhomocysteine Metabolic Process Kynurenine-glyoxylate Transaminase Activity GET Complex Regulation Of Protein Catabolic Process Negative Regulation Of Catabolic Process Phosphorylation Regulation Of Fibroblast Proliferation D-xylose Metabolic Process L-lysine Catabolic Process To Acetyl-CoA Via Saccharopine