DDR2

Gene Name		discoidin domain receptor tyrosine kinase 2
Image
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion Apical Plasma Membrane Extracellular Vesicular Exosome
	Molecular Function	Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Binding Collagen Binding ATP Binding Protein Tyrosine Kinase Collagen Receptor Activity
	Biological Process	Ossification Endochondral Bone Growth Cell Adhesion Signal Transduction Regulation Of Extracellular Matrix Disassembly Positive Regulation Of Fibroblast Migration Peptidyl-tyrosine Phosphorylation Extracellular Matrix Organization Collagen Fibril Organization Regulation Of Bone Mineralization Biomineral Tissue Development Chondrocyte Proliferation Collagen-activated Tyrosine Kinase Receptor Signaling Pathway Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Protein Kinase Activity Protein Autophosphorylation Positive Regulation Of Fibroblast Proliferation Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Extracellular Matrix Disassembly
Pathways		Non-integrin membrane-ECM interactions
Drugs
Diseases
GWAS
Protein-protein Interactions		4 interactors: COL1A1 COL3A1 SHC1 SRC
Entrez ID		4921
HPRD ID		01868
Ensembl ID		ENSG00000162733
Uniprot IDs		Q16832
PDB IDs		2WUH 2Z4F
Enriched GO Terms of Interacting Partners?		Platelet Activation Blood Coagulation Hemostasis Cellular Response To Organonitrogen Compound Regulation Of Body Fluid Levels Cellular Response To Growth Factor Stimulus Wound Healing Response To Growth Factor Cell Activation Response To Wounding Cellular Response To Acid Chemical Response To Organonitrogen Compound Cellular Response To Transforming Growth Factor Beta Stimulus Cellular Response To Fibroblast Growth Factor Stimulus Response To Transforming Growth Factor Beta Response To Fibroblast Growth Factor Response To Mechanical Stimulus Leukocyte Migration Locomotion Positive Regulation Of Signal Transduction Movement Of Cell Or Subcellular Component Negative Regulation Of Cell-substrate Adhesion Response To Peptide Hormone Response To Peptide Cellular Response To Amino Acid Stimulus Blood Vessel Development Collagen Fibril Organization Cellular Response To Organic Substance Collagen Catabolic Process Vasculature Development Skeletal System Development Regulation Of Cell Migration Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Regulation Of Cell Motility Multicellular Organismal Metabolic Process Endocytosis Extracellular Matrix Disassembly Regulation Of Locomotion Regulation Of Cellular Component Movement Response To Cytokine Anatomical Structure Morphogenesis Response To Organic Substance Response To Amino Acid Head Development Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Canonical Wnt Signaling Pathway Cellular Response To Fluoride Integrin-mediated Signaling Pathway Response To Hydrogen Peroxide
Tagcloud ?		aacr adaptive adaptor compensatory conversely cotargeting dampen dasatinib driven emerged gab1 harboring igf1r implicating irs2 library met option overlaying panel phosphoproteomics py rationale res rescued rtk scc synergistic weakly