DDR2 and COL1A1

Number of citations of the paper that reports this interaction (PMID 9659899)
120

Data Source:
HPRD (in vitro)

		DDR2	COL1A1
Gene Name		discoidin domain receptor tyrosine kinase 2	collagen, type I, alpha 1
Image
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion Apical Plasma Membrane Extracellular Vesicular Exosome	Extracellular Region Collagen Type I Trimer Extracellular Space Endoplasmic Reticulum Lumen Golgi Apparatus Secretory Granule Extracellular Matrix
	Molecular Function	Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Binding Collagen Binding ATP Binding Protein Tyrosine Kinase Collagen Receptor Activity	Extracellular Matrix Structural Constituent Protein Binding Identical Protein Binding Metal Ion Binding Platelet-derived Growth Factor Binding
	Biological Process	Ossification Endochondral Bone Growth Cell Adhesion Signal Transduction Regulation Of Extracellular Matrix Disassembly Positive Regulation Of Fibroblast Migration Peptidyl-tyrosine Phosphorylation Extracellular Matrix Organization Collagen Fibril Organization Regulation Of Bone Mineralization Biomineral Tissue Development Chondrocyte Proliferation Collagen-activated Tyrosine Kinase Receptor Signaling Pathway Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Protein Kinase Activity Protein Autophosphorylation Positive Regulation Of Fibroblast Proliferation Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Extracellular Matrix Disassembly	Skeletal System Development Blood Vessel Development Osteoblast Differentiation Intramembranous Ossification Endochondral Ossification Receptor-mediated Endocytosis Blood Coagulation Visual Perception Sensory Perception Of Sound Positive Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Cell-substrate Adhesion Protein Transport Extracellular Matrix Disassembly Platelet Activation Extracellular Matrix Organization Collagen Fibril Organization Positive Regulation Of Cell Migration Collagen Catabolic Process Response To Corticosteroid Response To Estradiol Collagen Biosynthetic Process Protein Localization To Nucleus Tooth Mineralization Response To Drug Response To Hydrogen Peroxide Response To Peptide Hormone Skin Morphogenesis Cellular Response To Fibroblast Growth Factor Stimulus Tooth Eruption Positive Regulation Of Transcription, DNA-templated Embryonic Skeletal System Development Leukocyte Migration Response To CAMP Response To Hyperoxia Face Morphogenesis Bone Trabecula Formation Cartilage Development Involved In Endochondral Bone Morphogenesis Protein Heterotrimerization Cellular Response To Amino Acid Stimulus Cellular Response To Mechanical Stimulus Cellular Response To Retinoic Acid Cellular Response To Vitamin E Cellular Response To Tumor Necrosis Factor Cellular Response To Epidermal Growth Factor Stimulus Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Canonical Wnt Signaling Pathway Cellular Response To Fluoride
Pathways		Non-integrin membrane-ECM interactions	Platelet Adhesion to exposed collagen Collagen formation Collagen degradation Anchoring fibril formation Non-integrin membrane-ECM interactions Degradation of the extracellular matrix Assembly of collagen fibrils and other multimeric structures Cell surface interactions at the vascular wall Syndecan interactions Crosslinking of collagen fibrils ECM proteoglycans GPVI-mediated activation cascade Integrin cell surface interactions Collagen biosynthesis and modifying enzymes Platelet activation, signaling and aggregation Scavenging by Class A Receptors
Drugs			Collagenase
Diseases
GWAS			Breast cancer ( 17903305) Response to taxane treatment (docetaxel) ( 23006423)
Protein-Protein Interactions		4 interactors: COL1A1 COL3A1 SHC1 SRC	37 interactors: ACHE ATP13A2 BARD1 BGN BMP1 BRCA1 CAPN1 CD36 CD44 CD93 COL7A1 DCN DDR2 FGF7 FN1 HTRA1 IGFBP3 ITGA2 ITGA5 MAG MATN2 MMP2 MMP9 NID1 NID2 P4HB PAK1 PDGFA PDGFB PKD1 PRELP SPARC TGFBI THBS1 TMPRSS6 TXN VWF
Entrez ID		4921	1277
HPRD ID		01868	00362
Ensembl ID		ENSG00000162733	ENSG00000108821
Uniprot IDs		Q16832	P02452
PDB IDs		2WUH 2Z4F	1Q7D 2LLP 3EJH 3GXE
Enriched GO Terms of Interacting Partners?		Platelet Activation Blood Coagulation Hemostasis Cellular Response To Organonitrogen Compound Regulation Of Body Fluid Levels Cellular Response To Growth Factor Stimulus Wound Healing Response To Growth Factor Cell Activation Response To Wounding Cellular Response To Acid Chemical Response To Organonitrogen Compound Cellular Response To Transforming Growth Factor Beta Stimulus Cellular Response To Fibroblast Growth Factor Stimulus Response To Transforming Growth Factor Beta Response To Fibroblast Growth Factor Response To Mechanical Stimulus Leukocyte Migration Locomotion Positive Regulation Of Signal Transduction Movement Of Cell Or Subcellular Component Negative Regulation Of Cell-substrate Adhesion Response To Peptide Hormone Response To Peptide Cellular Response To Amino Acid Stimulus Blood Vessel Development Collagen Fibril Organization Cellular Response To Organic Substance Collagen Catabolic Process Vasculature Development Skeletal System Development Regulation Of Cell Migration Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Regulation Of Cell Motility Multicellular Organismal Metabolic Process Endocytosis Extracellular Matrix Disassembly Regulation Of Locomotion Regulation Of Cellular Component Movement Response To Cytokine Anatomical Structure Morphogenesis Response To Organic Substance Response To Amino Acid Head Development Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Canonical Wnt Signaling Pathway Cellular Response To Fluoride Integrin-mediated Signaling Pathway Response To Hydrogen Peroxide	Extracellular Matrix Organization Extracellular Structure Organization Response To Wounding Extracellular Matrix Disassembly Wound Healing Multicellular Organismal Development Cell Adhesion Anatomical Structure Development Tissue Development Platelet Degranulation Developmental Process System Development Blood Coagulation Hemostasis Anatomical Structure Morphogenesis Positive Regulation Of Epithelial Cell Migration Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Regulation Of Cell Motility Positive Regulation Of Locomotion Positive Regulation Of Protein Metabolic Process Regulation Of Locomotion Regulation Of Cellular Amino Acid Metabolic Process Response To Stress Regulation Of Cellular Component Movement Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Body Fluid Levels Regulation Of Cell Migration Cell-substrate Adhesion Regulation Of Epithelial Cell Migration Regulation Of Cellular Ketone Metabolic Process Positive Regulation Of Phosphorylation Endodermal Cell Differentiation Regulation Of Protein Metabolic Process Positive Regulation Of Protein Modification Process Positive Regulation Of Protein Phosphorylation Skeletal System Development Regulation Of Cellular Protein Metabolic Process Organ Development Blood Vessel Morphogenesis Regulation Of Phosphorus Metabolic Process Platelet Activation Organ Morphogenesis Locomotion Endoderm Formation Angiogenesis Regulation Of Protein Phosphorylation Regulation Of Phosphorylation Exocytosis
Tagcloud ?		aacr adaptive adaptor compensatory conversely cotargeting dampen dasatinib driven emerged gab1 harboring igf1r implicating irs2 library met option overlaying panel phosphoproteomics py rationale res rescued rtk scc synergistic weakly	archive bcl6 cancerous cebpb checked cufflinks david deg degs downloaded exph5 fastqc hg19 msx2 noiseq paracancerous ppp2r2c read samtools sox4 srp009386 tophat totally transfa trp53 uniquely v1 vcftools
Tagcloud (Difference) ?		aacr adaptive adaptor compensatory conversely cotargeting dampen dasatinib driven emerged gab1 harboring igf1r implicating irs2 library met option overlaying panel phosphoproteomics py rationale res rescued rtk scc synergistic weakly	archive bcl6 cancerous cebpb checked cufflinks david deg degs downloaded exph5 fastqc hg19 msx2 noiseq paracancerous ppp2r2c read samtools sox4 srp009386 tophat totally transfa trp53 uniquely v1 vcftools
Tagcloud (Intersection) ?