NPTX1 and CASP10

Data Source: HiPPIP (Novel)

		NPTX1	CASP10
Name		neuronal pentraxin 1	caspase 10
Structure			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Endoplasmic Reticulum Transport Vesicle Cytoplasmic Vesicle Synaptic Cleft Glutamatergic Synapse	Cytoplasm Cytosol CD95 Death-inducing Signaling Complex Ripoptosome
	Molecular Function	Metal Ion Binding	Cysteine-type Endopeptidase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity Ubiquitin Protein Ligase Binding Death Effector Domain Binding
	Biological Process	Mitochondrial Transport Chemical Synaptic Transmission Central Nervous System Development Cellular Response To Potassium Ion Mitochondrial Fragmentation Involved In Apoptotic Process Axonogenesis Involved In Innervation Cellular Response To Glucose Stimulus Postsynaptic Density Assembly Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane	Proteolysis Apoptotic Process Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Neuron Apoptotic Process Protein Maturation Execution Phase Of Apoptosis Positive Regulation Of Execution Phase Of Apoptosis
Pathways		None	TP53 Regulates Transcription of Caspase Activators and Caspases FasL/ CD95L signaling TRAIL signaling NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
Diseases		None	Autoimmune lymphoproliferative syndromes (ALPS), including the following five diseases: CD95 (Fas) defect, ALPS type 1a; CD95L (Fas ligand) defect, ALPS type 1b; Caspase 10 defect, ALPS type 2a; Caspase 8 defext, ALPS type 2b; Activaing N-Ras defect, N-Ras ALPS
GWAS		Bipolar disorder ( 31043756 ) Blood protein levels ( 30072576 )	Alanine aminotransferase levels ( 33547301 ) Basal cell carcinoma ( 25855136 ) Chronic lymphocytic leukemia ( 23770605 28165464 ) Chronic lymphocytic leukemia or rheumatoid arthritis ( 31407831 ) Mean corpuscular hemoglobin ( 32888494 )
Novel Interactors		7 novel interactors: CASP10 FN1 MXRA7 NPTX2 SLC3A1 STX1B ZNF92	6 novel interactors: BMPR2 ERBB4 IGFBP2 NPTX1 SCARB1 YBX3
Interacting Genes		3 interacting genes: ADRB2 NPTXR RCN2	30 interacting genes: BFAR BID CASP1 CASP14 CASP2 CASP3 CASP4 CASP6 CASP7 CASP8 CASP8AP2 CASP9 CCAR1 CFLAR DEDD DEDD2 DSP ECE2 FADD NFKBIL1 OIP5 PHF20L1 POLR2A PRDX6 RB1 RIOK3 RYBP TNFRSF1A TRAF1 XIAP
Entrez ID		4884	843
HPRD ID		03843	03458
Ensembl ID		ENSG00000171246	ENSG00000003400
Uniprot IDs		Q15818	A0A0S2Z3G5 A0A0S2Z3Z5 Q92851
PDB IDs		6YPE	Not available
GO Terms Enriched among Interactors		Positive Regulation Of Excitatory Postsynaptic Potential Regulation Of Systemic Arterial Blood Pressure By Norepinephrine-epinephrine Modulation Of Excitatory Postsynaptic Potential Positive Regulation Of Mini Excitatory Postsynaptic Potential Positive Regulation Of Spontaneous Neurotransmitter Secretion Negative Regulation Of Macropinocytosis Negative Regulation Of Synaptic Vesicle Recycling	Cell Death Programmed Cell Death Apoptotic Process Cysteine-type Endopeptidase Activity Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Positive Regulation Of Neuron Apoptotic Process Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Cysteine-type Peptidase Activity Death Receptor Binding Extrinsic Apoptotic Signaling Pathway Protein Processing Pyroptotic Inflammatory Response Death-inducing Signaling Complex Regulation Of Canonical NF-kappaB Signal Transduction Execution Phase Of Apoptosis Regulation Of Neuron Apoptotic Process Neuron Apoptotic Process Regulation Of Necroptotic Process Cellular Response To Mechanical Stimulus Protein Maturation Regulation Of Programmed Necrotic Cell Death Cell Surface Receptor Signaling Pathway Peptidase Activity Cellular Response To Staurosporine Proteolysis Epithelial Cell Apoptotic Process Regulation Of Signal Transduction Glial Cell Apoptotic Process Positive Regulation Of Execution Phase Of Apoptosis Response To Mechanical Stimulus Response To Anesthetic Ripoptosome CD95 Death-inducing Signaling Complex Response To Lipopolysaccharide Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Defense Response Response To Molecule Of Bacterial Origin Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Signaling Regulation Of Cell Communication Response To Stress Regulation Of Defense Response Regulation Of Intracellular Signal Transduction Response To Cobalt Ion Regulation Of Apoptotic Signaling Pathway Fibroblast Apoptotic Process