NPTX1 and SLC3A1

Number of citations of the paper that reports this interaction (PubMedID 40355756)
172

Data Source:
BioGRID (affinity chromatography technology)

		NPTX1	SLC3A1
Description		neuronal pentraxin 1	solute carrier family 3 member 1
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GO Annotations	Cellular Component	Extracellular Region Endoplasmic Reticulum Transport Vesicle Cytoplasmic Vesicle Synaptic Cleft Glutamatergic Synapse	Vacuolar Membrane Plasma Membrane Membrane Apical Plasma Membrane Brush Border Membrane Extracellular Exosome
	Molecular Function	Metal Ion Binding	Protein Binding Amino Acid Transmembrane Transporter Activity Basic Amino Acid Transmembrane Transporter Activity L-cystine Transmembrane Transporter Activity Protein-containing Complex Binding Protein Heterodimerization Activity
	Biological Process	Mitochondrial Transport Chemical Synaptic Transmission Central Nervous System Development Cellular Response To Potassium Ion Mitochondrial Fragmentation Involved In Apoptotic Process Axonogenesis Involved In Innervation Cellular Response To Glucose Stimulus Postsynaptic Density Assembly Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane	Carbohydrate Metabolic Process Amino Acid Transport Gene Expression Basic Amino Acid Transport Aspartate Transmembrane Transport L-cystine Transport L-glutamate Transmembrane Transport Basic Amino Acid Transmembrane Transport
Pathways			Amino acid transport across the plasma membrane Defective SLC3A1 causes cystinuria (CSNU) Defective SLC7A9 causes cystinuria (CSNU)
Drugs
Diseases			Cystinuria
GWAS		Bipolar disorder ( 31043756) Blood protein levels ( 30072576)	antipsychotic drug dosage in schizophrenia or schizoaffective disorder ( 26821981) Refractive error ( 32231278)
Interacting Genes		3 interacting genes: ADRB2 NPTXR RCN2	1 interacting genes: SLC7A8
Entrez ID		4884	6519
HPRD ID		03843	00090
Ensembl ID		ENSG00000171246	ENSG00000138079
Uniprot IDs		Q15818	A0A0S2Z4E1 B8ZZK1 Q07837
PDB IDs		6YPE	6LI9 6LID 6YUP 6YUZ
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Excitatory Postsynaptic Potential Regulation Of Systemic Arterial Blood Pressure By Norepinephrine-epinephrine Modulation Of Excitatory Postsynaptic Potential Positive Regulation Of Mini Excitatory Postsynaptic Potential Positive Regulation Of Spontaneous Neurotransmitter Secretion Negative Regulation Of Macropinocytosis Negative Regulation Of Synaptic Vesicle Recycling	Postsynaptic Density Assembly Axonogenesis Involved In Innervation Mitochondrial Fragmentation Involved In Apoptotic Process Postsynaptic Specialization Assembly L-alanine Transport Tryptophan Transport Branched-chain Amino Acid Transport Proline Transmembrane Transport Organic Cation Transmembrane Transporter Activity Aromatic Amino Acid Transport L-alanine Transmembrane Transport L-leucine Transmembrane Transporter Activity Toxin Transmembrane Transporter Activity L-leucine Transport L-leucine Import Across Plasma Membrane Glycine Transmembrane Transporter Activity L-alanine Transmembrane Transporter Activity L-alanine Import Across Plasma Membrane Thyroid Hormone Transmembrane Transporter Activity Valine Transport Thyroid Hormone Transport Glycine Transport Cellular Response To Potassium Ion L-amino Acid Transmembrane Transporter Activity Alanine Transport Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Postsynaptic Density Organization Neutral L-amino Acid Transmembrane Transporter Activity Response To Potassium Ion Synaptic Cleft Postsynaptic Specialization Organization Microvillus Membrane Amino Acid Transmembrane Transporter Activity Protein Localization To Postsynaptic Membrane Protein Localization To Postsynapse Mitochondrial Transport Amino Acid Import Across Plasma Membrane Peptide Antigen Binding Neutral Amino Acid Transport Receptor Localization To Synapse L-alpha-amino Acid Transmembrane Transport Protein Localization To Synapse Cellular Response To Glucose Stimulus Protein-containing Complex Localization Apoptotic Mitochondrial Changes Basal Plasma Membrane Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels L-amino Acid Transport Cellular Response To Carbohydrate Stimulus Transport Across Blood-brain Barrier
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