NPTX1 and NPTX2

Number of citations: 97 (PubMedID 33961781)
Data Source: BioGRID (affinity chromatography technology)

		NPTX1	NPTX2
Name		neuronal pentraxin 1	neuronal pentraxin 2
Structure			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Endoplasmic Reticulum Transport Vesicle Cytoplasmic Vesicle Synaptic Cleft Glutamatergic Synapse	Extracellular Region Synapse Presynapse Glutamatergic Synapse
	Molecular Function	Metal Ion Binding	Protein Binding Carbohydrate Binding Metal Ion Binding
	Biological Process	Mitochondrial Transport Chemical Synaptic Transmission Central Nervous System Development Cellular Response To Potassium Ion Mitochondrial Fragmentation Involved In Apoptotic Process Axonogenesis Involved In Innervation Cellular Response To Glucose Stimulus Postsynaptic Density Assembly Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane	Chemical Synaptic Transmission Associative Learning
GWAS		Bipolar disorder ( 31043756 ) Blood protein levels ( 30072576 )	No GWAS studies recorded
Novel Interactors		7 novel interactors: CASP10 FN1 MXRA7 NPTX2 SLC3A1 STX1B ZNF92	3 novel interactors: DYNC1I1 NIN NPTX1
Interacting Genes		3 interacting genes: ADRB2 NPTXR RCN2	1 interacting genes: NPTXR
Entrez ID		4884	4885
HPRD ID		03843	02853
Ensembl ID		ENSG00000171246	ENSG00000106236
Uniprot IDs		Q15818	P47972
PDB IDs		6YPE	Not available
GO Terms Enriched among Interactors		Positive Regulation Of Excitatory Postsynaptic Potential Regulation Of Systemic Arterial Blood Pressure By Norepinephrine-epinephrine Modulation Of Excitatory Postsynaptic Potential Positive Regulation Of Mini Excitatory Postsynaptic Potential Positive Regulation Of Spontaneous Neurotransmitter Secretion Negative Regulation Of Macropinocytosis Negative Regulation Of Synaptic Vesicle Recycling	Dynein Heavy Chain Binding Dynein Light Chain Binding Microtubule Spindle Pole Cell Projection Morphogenesis Postsynaptic Density Assembly Cellular Response To Potassium Ion Axonogenesis Involved In Innervation Axonogenesis Neuron Projection Morphogenesis Mitochondrial Fragmentation Involved In Apoptotic Process Postsynaptic Specialization Assembly Microtubule Anchoring At Centrosome Corticospinal Tract Morphogenesis Centriolar Subdistal Appendage Ciliary Transition Fiber Centriole-centriole Cohesion Microtubule Nucleation By Microtubule Organizing Center Microtubule Minus-end Binding Corpus Callosum Morphogenesis Centrosome-templated Microtubule Nucleation Microtubule Anchoring At Microtubule Organizing Center Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Postsynaptic Density Organization Collateral Sprouting Cytoplasmic Dynein Complex Response To Potassium Ion Postsynaptic Specialization Organization Synaptic Cleft Axonal Growth Cone Pericentriolar Material Central Nervous System Projection Neuron Axonogenesis Microtubule Anchoring Spectrin Binding Glutamatergic Synapse Protein Localization To Postsynapse Protein Localization To Postsynaptic Membrane Microtubule Nucleation Central Nervous System Neuron Axonogenesis Centrosome Localization Dynein Complex Mitochondrial Transport Mitotic Spindle Pole Vesicle Transport Along Microtubule Receptor Localization To Synapse Cytoskeletal Motor Activity Microtubule-based Process Vesicle Cytoskeletal Trafficking Microtubule Motor Activity Cytoplasmic Microtubule