GZMM and EZR

Number of citations of the paper that reports this interaction (PMID 18523284)
11

Data Source:
BioGRID (enzymatic study)

		GZMM	EZR
Gene Name		granzyme M (lymphocyte met-ase 1)	ezrin
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Membrane	Ruffle Uropod Extracellular Space Nucleolus Cytosol Actin Filament Plasma Membrane Microvillus Focal Adhesion Actin Cytoskeleton Membrane Basolateral Plasma Membrane Apical Plasma Membrane Extrinsic Component Of Membrane Filopodium T-tubule Cortical Cytoskeleton Microvillus Membrane Vesicle Ruffle Membrane Ciliary Basal Body Cell Body Microspike Membrane Raft Apical Part Of Cell Cell Tip Extracellular Vesicular Exosome Cell Periphery Astrocyte Projection Schwann Cell Microvillus
	Molecular Function	Serine-type Endopeptidase Activity Serine-type Peptidase Activity	Protein Binding Protein Domain Specific Binding Poly(A) RNA Binding Cell Adhesion Molecule Binding Actin Filament Binding
	Biological Process	Proteolysis Apoptotic Process Cytolysis Innate Immune Response	Cytoskeletal Anchoring At Plasma Membrane Leukocyte Cell-cell Adhesion Axon Guidance Regulation Of Cell Shape Positive Regulation Of Gene Expression Membrane To Membrane Docking Microvillus Assembly Receptor Internalization Establishment Of Epithelial Cell Apical/basal Polarity Filopodium Assembly Actin Filament Bundle Assembly Establishment Of Endothelial Barrier
Pathways		Alternative complement activation Complement cascade Initial triggering of complement Innate Immune System	Axon guidance L1CAM interactions Netrin-1 signaling Recycling pathway of L1
Drugs
Diseases
GWAS
Protein-Protein Interactions		5 interactors: DFFA EZR NPM1 PARP1 TUBA1B	49 interactors: ACTB ACTC1 ADORA2B ADRA1B ARF6 ARHGDIB CD44 CDH1 CDK5 CFTR CLIC5 CTNNB1 DLG1 EGFR FAS FASLG GZMM ICAM1 ICAM2 ICAM3 IQGAP1 L1CAM LCK MDM2 MPP3 MSN NF2 PALLD PIK3R1 PRKAR2A PRKCA PTK2 PTPRC RDX ROCK1 S100P SCYL3 SDC2 SELL SELP SLC9A3R1 SLC9A3R2 SPN TBC1D10A TMEM8B TSC1 VCAM1 WFDC1 WWOX
Entrez ID		3004	7430
HPRD ID		02633	00475
Ensembl ID		ENSG00000197540	ENSG00000092820
Uniprot IDs		P51124	P15311
PDB IDs		1LZP 2ZGC 2ZGH 2ZGJ 2ZKS	1NI2
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Apoptotic DNA Fragmentation Regulation Of Endoribonuclease Activity Regulation Of EIF2 Alpha Phosphorylation By DsRNA Regulation Of Growth Rate Protein Poly-ADP-ribosylation Regulation Of Ribonuclease Activity Regulation Of Endodeoxyribonuclease Activity DNA Metabolic Process Membrane To Membrane Docking Cytoskeleton Organization Negative Regulation Of Protein Kinase Activity By Regulation Of Protein Phosphorylation Organelle Organization Regulation Of Apoptotic DNA Fragmentation DNA Damage Response, Detection Of DNA Damage Thymocyte Apoptotic Process Negative Regulation Of Execution Phase Of Apoptosis Positive Regulation Of Transcription Regulatory Region DNA Binding Protein Autoprocessing Cytoskeletal Anchoring At Plasma Membrane Regulation Of Centriole Replication Positive Regulation Of Gene Expression Positive Regulation Of SMAD Protein Import Into Nucleus Microvillus Assembly Microvillus Organization Negative Regulation Of Centrosome Duplication Microtubule Cytoskeleton Organization Regulation Of SMAD Protein Import Into Nucleus T Cell Apoptotic Process Filopodium Assembly Apoptotic DNA Fragmentation Macrophage Differentiation Cellular Response To Organic Substance Cellular Component Assembly Cellular Response To Superoxide Regulation Of Cellular Component Organization Response To Stimulus Regulation Of Transcription Regulatory Region DNA Binding Regulation Of Execution Phase Of Apoptosis CENP-A Containing Nucleosome Assembly Response To Superoxide Protein ADP-ribosylation Response To Oxygen Radical Establishment Of Endothelial Barrier Negative Regulation Of Cellular Metabolic Process DNA Repair Ribosome Assembly Apoptotic Nuclear Changes Cellular Macromolecular Complex Assembly Histone Exchange Signal Transduction Involved In Regulation Of Gene Expression	Cell Adhesion Single Organismal Cell-cell Adhesion Movement Of Cell Or Subcellular Component Locomotion Cell Migration Regulation Of Immune System Process Regulation Of Cell Adhesion Cell Motility Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Response To Organic Substance Leukocyte Migration Regulation Of Signaling Leukocyte Cell-cell Adhesion Organ Development Membrane To Membrane Docking Positive Regulation Of Cellular Protein Metabolic Process Response To Organonitrogen Compound Regulation Of Cell-cell Adhesion Cell Differentiation Immune System Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Immune Response Regulation Of Phosphorylation Cell Activation Apoptotic Process Regulation Of Protein Metabolic Process Programmed Cell Death Regulation Of Immune Response System Development Response To Growth Factor Cell Death Anatomical Structure Development Death Response To External Stimulus Positive Regulation Of Metabolic Process Regulation Of Phosphorus Metabolic Process Regulation Of Catalytic Activity Multicellular Organismal Development Blood Coagulation Developmental Process Hemostasis Defense Response Response To Radiation Positive Regulation Of Phosphorylation Cellular Response To Growth Factor Stimulus Response To Stimulus Cell Development Regulation Of Body Fluid Levels
Tagcloud ?			actg2 adenomatous archived b4ganlt2 bank casp3 cdx1 cdx2 classifier cnn1 col1a1 custom fsp1 genomelab hcellmarkerplex house hybridisation incorporates krt18 lgr5 ms4a12 muc2 mucin nox1 ntn1 polyp signatures slc9a2 vwf
Tagcloud (Difference) ?			actg2 adenomatous archived b4ganlt2 bank casp3 cdx1 cdx2 classifier cnn1 col1a1 custom fsp1 genomelab hcellmarkerplex house hybridisation incorporates krt18 lgr5 ms4a12 muc2 mucin nox1 ntn1 polyp signatures slc9a2 vwf
Tagcloud (Intersection) ?