GZMM and DFFA

Number of citations of the paper that reports this interaction (PubMedID 16818775)
0

Data Source:
BioGRID (enzymatic study)

		GZMM	DFFA
Description		granzyme M	DNA fragmentation factor subunit alpha
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Membrane	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Protein-containing Complex
	Molecular Function	Endopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity	Protein Binding Protein Domain Specific Binding Protein Folding Chaperone Deoxyribonuclease Inhibitor Activity
	Biological Process	T Cell Mediated Cytotoxicity Immune System Process Proteolysis Apoptotic Process Killing Of Cells Of Another Organism Innate Immune Response Protein Maturation	Apoptotic DNA Fragmentation Protein Folding Apoptotic Process Negative Regulation Of Deoxyribonuclease Activity Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Thymocyte Apoptotic Process Negative Regulation Of Execution Phase Of Apoptosis Negative Regulation Of Apoptotic DNA Fragmentation
Pathways		Alternative complement activation	Apoptosis induced DNA fragmentation
Drugs
Diseases
GWAS			Depression in smokers ( 30219690) Male-pattern baldness ( 28196072 29146897)
Interacting Genes		6 interacting genes: DFFA EZR NPM1 PARP1 TUBA1B ZNF774	12 interacting genes: AGO2 CASP3 CASP7 CIDEB DFFB EWSR1 GZMB GZMM NECAB2 STRN4 YWHAG YWHAZ
Entrez ID		3004	1676
HPRD ID		02633	03531
Ensembl ID		ENSG00000197540	ENSG00000160049
Uniprot IDs		P51124 U3KQV5	O00273
PDB IDs		2ZGC 2ZGH 2ZGJ 2ZKS	1IBX 1IYR 1KOY
Enriched GO Terms of Interacting Partners?		Macrophage Differentiation NAD+-histone H3S10 Serine ADP-ribosyltransferase Activity NAD+-histone H2BS6 Serine ADP-ribosyltransferase Activity Protein-DNA Complex NAD+-histone H2BE35 Glutamate ADP-ribosyltransferase Activity Protein-containing Complex NAD+-protein-histidine ADP-ribosyltransferase Activity Positive Regulation Of Protein Localization NAD+-protein-tyrosine ADP-ribosyltransferase Activity Regulation Of MRNA Stability Involved In Cellular Response To UV Regulation Of EIF2 Alpha Phosphorylation By DsRNA Cellular Response To UV DNA Metabolic Process DNA ADP-ribosylation Positive Regulation Of Myofibroblast Differentiation Cellular Response To Light Stimulus Regulation Of Base-excision Repair Myeloid Leukocyte Differentiation Response To UV Negative Regulation Of ATP Biosynthetic Process Cellular Response To Radiation NAD+-protein-serine ADP-ribosyltransferase Activity ATP Generation From Poly-ADP-D-ribose Negative Regulation Of DNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Protein Localization To Nucleus NAD DNA ADP-ribosyltransferase Activity Negative Regulation Of Phosphate Metabolic Process Positive Regulation Of Protein Localization To Nucleus Negative Regulation Of Deoxyribonuclease Activity Negative Regulation Of Apoptotic DNA Fragmentation Deoxyribonuclease Inhibitor Activity Negative Regulation Of Nuclease Activity Negative Regulation Of Catalytic Activity Regulation Of Endoribonuclease Activity Intestinal Hexose Absorption Terminal Web Assembly Protein Localization To Cell Cortex Intestinal D-glucose Absorption Transcription Pausing By RNA Polymerase II Replication Fork Reversal Negative Regulation Of Protein Kinase Activity By Regulation Of Protein Phosphorylation Regulation Of Ribonuclease Activity Positive Regulation Of Centrosome Duplication Membrane To Membrane Docking Regulation Of Microvillus Length Microtubule-based Process Positive Regulation Of Protein Localization To Nucleolus Ribosomal Large Subunit Export From Nucleus Regulation Of Nucleobase-containing Compound Metabolic Process	Execution Phase Of Apoptosis Cellular Response To Staurosporine Pyroptotic Inflammatory Response Cell Death Apoptotic Process Programmed Cell Death Protein Domain Specific Binding Fibroblast Apoptotic Process Protein Maturation Protein Poly-ADP-ribosylation Positive Regulation Of Immune Response To Tumor Cell Regulation Of Amyloid Precursor Protein Biosynthetic Process Aspartic-type Endopeptidase Activity Regulation Of Primary Metabolic Process Regulation Of Synapse Maturation Peptidase Activity Plasma Membrane Repair Regulation Of Response To Tumor Cell Negative Regulation Of Translation Cellular Response To Alkaloid Regulation Of Glycoprotein Biosynthetic Process Hydrolase Activity Cytoplasm Protein Sequestering Activity Leukocyte Apoptotic Process Neuron Recognition Glutamatergic Synapse Negative Regulation Of Translational Initiation Postsynapse Cellular Response To Glucose Starvation Negative Regulation Of Macromolecule Metabolic Process Ceramide Biosynthetic Process Identical Protein Binding Endoribonuclease Activity, Cleaving SiRNA-paired MRNA Regulation Of Metabolic Process Proteolysis Cysteine-type Endopeptidase Activity TORC1 Signaling Negative Regulation Of TORC1 Signaling Positive Regulation Of Neuron Apoptotic Process Negative Regulation Of Metabolic Process Regulation Of Synapse Organization Striated Muscle Cell Differentiation Response To External Biotic Stimulus Phospholipase A2 Activator Activity Cytolytic Granule Lumen Leukocyte Mediated Cytotoxicity Synaptic Target Recognition Endoribonuclease Activity, Cleaving MiRNA-paired MRNA Negative Regulation Of G Protein-coupled Receptor Internalization
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