NPHP1 and BCAR1

Number of citations of the paper that reports this interaction (PMID 11493697)
28

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro, in vivo)

		NPHP1	BCAR1
Gene Name		nephronophthisis 1 (juvenile)	breast cancer anti-estrogen resistance 1
Image
Gene Ontology Annotations	Cellular Component	Cytosol Cytoskeleton Cell-cell Junction Adherens Junction Tight Junction Membrane Motile Cilium Photoreceptor Connecting Cilium Ciliary Transition Zone Ciliary Base	Ruffle Nucleolus Cytoplasm Cytosol Plasma Membrane Focal Adhesion Actin Cytoskeleton Lamellipodium
	Molecular Function	Structural Molecule Activity Protein Binding	Signal Transducer Activity Protein Binding SH3 Domain Binding Protein Kinase Binding
	Biological Process	Organelle Organization Signal Transduction Excretion Visual Behavior Single Organismal Cell-cell Adhesion Cell Projection Organization Actin Cytoskeleton Organization Cellular Protein Localization Photoreceptor Cell Outer Segment Organization Spermatid Differentiation Retina Development In Camera-type Eye	Regulation Of Cell Growth Actin Filament Organization Cell Adhesion Epidermal Growth Factor Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway Integrin-mediated Signaling Pathway Blood Coagulation Cell Proliferation Insulin Receptor Signaling Pathway Positive Regulation Of Endothelial Cell Migration Cell Migration Platelet Activation Positive Regulation Of Cell Migration Cellular Response To Hepatocyte Growth Factor Stimulus Regulation Of Apoptotic Process Platelet-derived Growth Factor Receptor Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Hepatocyte Growth Factor Receptor Signaling Pathway Antigen Receptor-mediated Signaling Pathway T Cell Receptor Signaling Pathway B Cell Receptor Signaling Pathway Cell Division Cell Chemotaxis
Pathways		Organelle biogenesis and maintenance Assembly of the primary cilium Anchoring of the basal body to the plasma membrane	Signaling by PDGF Signaling by VEGF Downstream signal transduction p130Cas linkage to MAPK signaling for integrins Integrin alphaIIb beta3 signaling Platelet activation, signaling and aggregation Platelet Aggregation (Plug Formation) VEGFA-VEGFR2 Pathway
Drugs
Diseases
GWAS			Crohn's disease (time to surgery) ( 23665963)
Protein-Protein Interactions		15 interactors: ADAM15 ARHGAP32 BCAR1 FLNA FLNB FLNC INVS KHDRBS1 NPHP3 NPHP4 PAK2 PTK2B TNK2 TUBB UBQLN4	52 interactors: ABL1 AJUBA ARHGAP32 BMX CASP3 CD2AP CRK CRKL CSPG4 DOCK1 E2F2 EFS ESR1 FES FXYD6 FYB FYN GRB2 GSN HCK HSPA5 INPPL1 LCK LYN MMP14 NCK1 NEDD9 NPHP1 PIK3R1 PKD1 PPAP2B PPP1R15A PTK2 PTK2B PTPN1 PTPN12 PTPRA PTPRF PTPRH PXN RAN RAPGEF1 SH2D3A SH2D3C SH3KBP1 SRC SRCIN1 TRIP6 TUBA4A UHRF2 VPS11 YWHAZ
Entrez ID		4867	9564
HPRD ID		09524	04248
Ensembl ID		ENSG00000144061	ENSG00000050820
Uniprot IDs		B4DQY0 C9JNM7 O15259	B2RBL9 B3KWE2 F5H855 P56945
PDB IDs		1S1N	1WYX 3T6G
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Signaling Pathway Signal Transduction Signaling Cell Communication Movement Of Cell Or Subcellular Component Actin Cytoskeleton Organization Vascular Endothelial Growth Factor Receptor Signaling Pathway Actin Filament-based Process Cytoskeleton Organization Cellular Response To Stimulus Response To Stimulus Integrin-mediated Signaling Pathway Innate Immune Response Regulation Of Signal Transduction Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Peptidyl-tyrosine Phosphorylation Tissue Homeostasis Photoreceptor Cell Maintenance Regulation Of Signaling Negative Regulation Of Wnt Signaling Pathway Peptidyl-tyrosine Autophosphorylation Cell Junction Assembly Protein Autophosphorylation Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Canonical Wnt Signaling Pathway Developmental Process Multicellular Organismal Homeostasis Tissue Development Cell Differentiation Regulation Of Growth Cell Projection Organization Cell Development Positive Regulation Of Endothelial Cell Migration Epithelial To Mesenchymal Transition Cell Adhesion Intracellular Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Retina Homeostasis Determination Of Stomach Left/right Asymmetry Determination Of Intestine Left/right Asymmetry Locomotion Regulation Of Wnt Signaling Pathway Actin Filament Organization Immune Response Positive Regulation Of Translation Anatomical Structure Development Mitotic Cell Cycle Defense Response Positive Regulation Of Epithelial Cell Migration Regulation Of Cell Growth	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Signal Transduction Peptidyl-tyrosine Autophosphorylation Signaling Cell Communication Cellular Response To Stimulus Response To Stimulus Cell Migration Cell Motility Intracellular Signal Transduction Positive Regulation Of Signal Transduction Regulation Of Phosphorylation Platelet Activation Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Catalytic Activity Regulation Of Kinase Activity Regulation Of Protein Phosphorylation Immune Response-activating Cell Surface Receptor Signaling Pathway Locomotion Cell Surface Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc Receptor Mediated Stimulatory Signaling Pathway Fc-gamma Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Response To Wounding ERBB Signaling Pathway Positive Regulation Of Protein Phosphorylation Regulation Of Phosphorus Metabolic Process Movement Of Cell Or Subcellular Component Wound Healing Regulation Of Protein Kinase Activity Regulation Of Signal Transduction Cell Adhesion Regulation Of Cellular Component Organization Blood Coagulation Regulation Of Catalytic Activity Hemostasis Protein Autophosphorylation Positive Regulation Of Protein Metabolic Process Fc Receptor Signaling Pathway Innate Immune Response Response To Organonitrogen Compound Cellular Response To Organonitrogen Compound Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Phosphorylation Cellular Response To Peptide Hormone Stimulus Signal Complex Assembly Regulation Of Signaling
Tagcloud ?		ahi1 bardet biedl c2cd3 cc2d2a cc2d2b ccdc135 cep76 cilia ciliogenesis ciliopathies dyneins gruber jbts jouberin joubert meckel midasins mks mks6 moxr nephronophthisis nphp4 rpgrip1 rpgrip1l tgl throw ttl	aldh1a1 anxa1 cldn1 crmp1 endpoint folr1 foxm1 il12rb2 il7r inconclusive kiaa1524 lox mcm7 mta1 mtdh ncoa3 ndrg2 nedd9 nes overview pbk ppm1d principally prognostication qualifying slc7a5 sqstm1 warranted wnt1
Tagcloud (Difference) ?		ahi1 bardet biedl c2cd3 cc2d2a cc2d2b ccdc135 cep76 cilia ciliogenesis ciliopathies dyneins gruber jbts jouberin joubert meckel midasins mks mks6 moxr nephronophthisis nphp4 rpgrip1 rpgrip1l tgl throw ttl	aldh1a1 anxa1 cldn1 crmp1 endpoint folr1 foxm1 il12rb2 il7r inconclusive kiaa1524 lox mcm7 mta1 mtdh ncoa3 ndrg2 nedd9 nes overview pbk ppm1d principally prognostication qualifying slc7a5 sqstm1 warranted wnt1
Tagcloud (Intersection) ?