NME2 and SVIL

Number of citations of the paper that reports this interaction (PubMedID 20309963)
81

Data Source:
BioGRID (two hybrid)

		NME2	SVIL
Description		NME/NM23 nucleoside diphosphate kinase 2	supervillin
Image
GO Annotations	Cellular Component	Ruffle Extracellular Region Nucleus Cytoplasm Cytosol Focal Adhesion Lamellipodium Secretory Granule Lumen Cell Projection Perinuclear Region Of Cytoplasm Extracellular Exosome Cell Periphery Ficolin-1-rich Granule Lumen	Podosome Nucleus Cytoplasm Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Actin Cytoskeleton Membrane Midbody Cleavage Furrow Microtubule Minus-end Cell Projection Costamere Anchoring Junction
	Molecular Function	Nucleotide Binding DNA-binding Transcription Activator Activity DNA Binding Nuclease Activity Nucleoside Diphosphate Kinase Activity Protein Histidine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity GDP Binding Identical Protein Binding Metal Ion Binding G-quadruplex DNA Binding	Actin Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Actin Filament Binding
	Biological Process	GTP Biosynthetic Process UTP Biosynthetic Process CTP Biosynthetic Process Cell Adhesion Integrin-mediated Signaling Pathway Nucleotide Metabolic Process Nucleoside Triphosphate Biosynthetic Process Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Keratinocyte Differentiation Regulation Of Epidermis Development Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II ITP Biosynthetic Process Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of DNA-templated Transcription Initiation	Cytoskeleton Organization Skeletal Muscle Tissue Development Actin Polymerization Or Depolymerization Positive Regulation Of Cytokinesis Actin Filament Severing Barbed-end Actin Filament Capping Muscle Structure Development
Pathways		Interconversion of nucleotide di- and triphosphates Neutrophil degranulation Azathioprine ADME Ribavirin ADME
Drugs		Guanosine-5'-Diphosphate
Diseases
GWAS		Bipolar disorder ( 31043756) Blood protein levels ( 30072576) Height ( 20881960)	Age-related cognitive decline (language) (slope of z-scores) ( 30954325) Bone fracture in osteoporosis ( 28580392) Dilated cardiomyopathy ( 33495596) Dilated cardiomyopathy (MTAG) ( 33495596) Estimated glomerular filtration rate ( 31152163) Lung function (FEV1/FVC) ( 28166213) Metabolite levels ( 23823483) Neurofibrillary tangles ( 25188341) Normalized brain volume ( 19010793) Platelet thrombus formation ( 22550155) Plateletcrit ( 32888494)
Interacting Genes		18 interacting genes: BNIPL CEBPA CTBP1 DNM1 GIT2 HERC3 HERC5 HERC6 MOB4 NME3 PPP2CA RAB5A RORA RORB SVIL TBXA2R TERF1 VIM	36 interacting genes: AR ATRX BUB1 CENPF DYNLT1 ESR1 FLNA HAX1 HMMR HSP90AA1 ITGB3BP KIF22 KIFC3 KMT2A KRT18 LMNA LMNB2 LUC7L2 MIF4GD MPHOSPH9 MRTFB NME2 NR3C1 ODF2 P2RX7 PAN3 PCNX3 PPARG SH3PXD2A STARD9 TGFB1I1 TMEM132D TNFAIP1 TRIP6 UXT YWHAG
Entrez ID		4831	6840
HPRD ID		01132	04992
Ensembl ID		ENSG00000243678	ENSG00000197321
Uniprot IDs		F6XY72 P22392 Q6FHN3	A0A6I8PIX7 O95425 Q569J5
PDB IDs		1NSK 1NUE 3BBB 3BBC 3BBF 7KPF 8PIE 8PYW	2K6M 2K6N
Enriched GO Terms of Interacting Partners?		White Fat Cell Differentiation Regulation Of Vesicle Size GDP Binding FAR/SIN/STRIPAK Complex Synaptic Vesicle Recycling Response To Lipid RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Integrated Stress Response Signaling Transcription Coregulator Binding Clathrin Coat Assembly Involved In Endocytosis Mitochondrial Outer Membrane Fusion Regulation Of Hippo Signaling Negative Regulation Of Hippo Signaling RNA Polymerase II CTD Heptapeptide Repeat S7 Phosphatase Activity RNA Polymerase II CTD Heptapeptide Repeat S2 Phosphatase Activity Thromboxane Receptor Activity Thromboxane A2 Signaling Pathway Thromboxane A2 Receptor Activity Negative Regulation Of Establishment Of Protein Localization To Telomere Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Establishment Of RNA Localization To Telomere Positive Regulation Of Shelterin Complex Assembly Transcription Corepressor Binding Cellular Response To Lipid Nuclear Receptor Activity	Organelle Organization Regulation Of MiRNA Transcription Regulation Of MiRNA Metabolic Process Estrogen Response Element Binding Cytoskeleton Identical Protein Binding Nucleus Regulation Of Organelle Organization Nuclear Receptor Activity Positive Regulation Of MiRNA Transcription Positive Regulation Of MiRNA Metabolic Process Cytoplasm Regulation Of Apoptotic Process Steroid Binding Regulation Of Programmed Cell Death Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nuclear Pore Localization Chromatin Binding Regulation Of Nucleobase-containing Compound Metabolic Process Nuclear Receptor-mediated Signaling Pathway Apoptotic Process Regulation Of Cellular Component Organization Positive Regulation Of Macromolecule Metabolic Process Cytosol Cell Death Programmed Cell Death Nitric-oxide Synthase Regulator Activity Positive Regulation Of Macromolecule Biosynthetic Process Spindle Regulation Of Gene Expression Regulation Of Chromosome Organization Nuclear Matrix Cytoskeleton Organization Prostate Gland Growth Positive Regulation Of Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Intracellular Protein Localization Chromosome Segregation Microtubule Binding Negative Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Microtubule-based Process Microtubule Motor Activity Hormone-mediated Signaling Pathway Regulation Of Primary Metabolic Process Positive Regulation Of Metabolic Process Response To Estrogen Chromatin Organization Nuclear Lamina Microtubule Cytoskeleton Organization Negative Regulation Of Apoptotic Process
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?