NME2 and MOB4

Number of citations of the paper that reports this interaction (PubMedID 11872741)
0

Data Source:
HPRD (in vitro)

		NME2	MOB4
Description		NME/NM23 nucleoside diphosphate kinase 2	MOB family member 4, phocein
Image
GO Annotations	Cellular Component	Ruffle Extracellular Region Nucleus Cytoplasm Cytosol Focal Adhesion Lamellipodium Secretory Granule Lumen Cell Projection Perinuclear Region Of Cytoplasm Extracellular Exosome Cell Periphery Ficolin-1-rich Granule Lumen	Cytoplasm Golgi Apparatus Membrane Golgi Cisterna Membrane Perinuclear Region Of Cytoplasm FAR/SIN/STRIPAK Complex Postsynapse Glutamatergic Synapse
	Molecular Function	Nucleotide Binding DNA-binding Transcription Activator Activity DNA Binding Nuclease Activity Nucleoside Diphosphate Kinase Activity Protein Histidine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity GDP Binding Identical Protein Binding Metal Ion Binding G-quadruplex DNA Binding	Protein Binding Protein-macromolecule Adaptor Activity Metal Ion Binding
	Biological Process	GTP Biosynthetic Process UTP Biosynthetic Process CTP Biosynthetic Process Cell Adhesion Integrin-mediated Signaling Pathway Nucleotide Metabolic Process Nucleoside Triphosphate Biosynthetic Process Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Keratinocyte Differentiation Regulation Of Epidermis Development Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II ITP Biosynthetic Process Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of DNA-templated Transcription Initiation	Negative Regulation Of Hippo Signaling
Pathways		Interconversion of nucleotide di- and triphosphates Neutrophil degranulation Azathioprine ADME Ribavirin ADME
Drugs		Guanosine-5'-Diphosphate
Diseases
GWAS		Bipolar disorder ( 31043756) Blood protein levels ( 30072576) Height ( 20881960)	Allergic rhinitis ( 31361310) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder or schizophrenia ( 28540026) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Crohn's disease ( 28067908) Schizophrenia ( 29483656) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		18 interacting genes: BNIPL CEBPA CTBP1 DNM1 GIT2 HERC3 HERC5 HERC6 MOB4 NME3 PPP2CA RAB5A RORA RORB SVIL TBXA2R TERF1 VIM	32 interacting genes: ARHGEF15 CCDC85B CRMP1 DNM1 EGFR EGLN2 ELK1 EPS15 FADD FBLN1 GDF9 KIDINS220 LATS1 LATS2 LRIF1 MAP4K4 MCM2 MED10 MED31 MYL6 MYO9B NME2 PAICS PLEKHM1 PTPRS RAPGEF2 SCMH1 SETDB1 STK11 STK3 THAP4 UBE2V2
Entrez ID		4831	25843
HPRD ID		01132	10165
Ensembl ID		ENSG00000243678	ENSG00000115540
Uniprot IDs		F6XY72 P22392 Q6FHN3	Q9Y3A3
PDB IDs		1NSK 1NUE 3BBB 3BBC 3BBF 7KPF 8PIE 8PYW	5YF4 7K36
Enriched GO Terms of Interacting Partners?		White Fat Cell Differentiation Regulation Of Vesicle Size GDP Binding FAR/SIN/STRIPAK Complex Synaptic Vesicle Recycling Response To Lipid RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Integrated Stress Response Signaling Transcription Coregulator Binding Clathrin Coat Assembly Involved In Endocytosis Mitochondrial Outer Membrane Fusion Regulation Of Hippo Signaling Negative Regulation Of Hippo Signaling RNA Polymerase II CTD Heptapeptide Repeat S7 Phosphatase Activity RNA Polymerase II CTD Heptapeptide Repeat S2 Phosphatase Activity Thromboxane Receptor Activity Thromboxane A2 Signaling Pathway Thromboxane A2 Receptor Activity Negative Regulation Of Establishment Of Protein Localization To Telomere Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Establishment Of RNA Localization To Telomere Positive Regulation Of Shelterin Complex Assembly Transcription Corepressor Binding Cellular Response To Lipid Nuclear Receptor Activity	Positive Regulation Of Hippo Signaling Hippo Signaling Regulation Of Growth Regulation Of Hippo Signaling Regulation Of Cell Junction Assembly Inner Cell Mass Cell Fate Commitment Inner Cell Mass Cellular Morphogenesis ATP Binding Nucleotide Binding Negative Regulation Of Growth Regulation Of Macromolecule Metabolic Process Regulation Of Protein Phosphorylation Regulation Of Cellular Component Organization Regulation Of Cell Growth Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Postsynapse Organization Kinase Activity Regulation Of Phosphorylation Negative Regulation Of Canonical Wnt Signaling Pathway Transcription Regulator Activator Activity Negative Regulation Of Cyclin-dependent Protein Kinase Activity Regulation Of Protein Modification Process Cell Surface Receptor Signaling Pathway Regulation Of Synapse Assembly Developmental Process Endocytic Vesicle Clathrin-coated Pit Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Regulation Of Wnt Signaling Pathway Protein Kinase Activity Regulation Of Intracellular Signal Transduction Regulation Of Metabolic Process Negative Regulation Of Cell Growth Positive Regulation Of DNA-templated Transcription Initiation Establishment Of Endothelial Intestinal Barrier Negative Regulation Of Wnt Signaling Pathway Nerve Growth Factor Signaling Pathway DNA Replication Origin Binding Regulation Of Postsynaptic Density Assembly Positive Regulation Of Cellular Component Biogenesis Protein-containing Complex Assembly Protein Phosphorylation Positive Regulation Of Apoptotic Process Regulation Of DNA-templated Transcription Initiation Protein Serine Kinase Activity Clathrin Coat Assembly Positive Regulation Of Programmed Cell Death Regulation Of Postsynaptic Specialization Assembly
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