NME2 and RAB5A

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		NME2	RAB5A
Gene Name		NME/NM23 nucleoside diphosphate kinase 2	RAB5A, member RAS oncogene family
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Gene Ontology Annotations	Cellular Component	Ruffle Nucleus Cytoplasm Mitochondrion Centrosome Cytosol Intermediate Filament Focal Adhesion Membrane Lamellipodium Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome Cell Periphery	Ruffle Cytoplasm Endosome Early Endosome Cytosol Plasma Membrane Synaptic Vesicle Endosome Membrane Actin Cytoskeleton Endocytic Vesicle Axon Dendrite Somatodendritic Compartment Melanosome Zymogen Granule Membrane Neuronal Cell Body Terminal Bouton Protein Complex Axon Terminus Membrane Raft Phagocytic Vesicle Perinuclear Region Of Cytoplasm Recycling Endosome Extracellular Vesicular Exosome Cytoplasmic Side Of Early Endosome Membrane
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding Single-stranded DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Nucleoside Diphosphate Kinase Activity Protein Histidine Kinase Activity Protein Binding ATP Binding Intermediate Filament Binding Protein Kinase Binding Gamma-tubulin Binding Metal Ion Binding	GTPase Activity Protein Binding GTP Binding GDP Binding GDP-dissociation Inhibitor Binding
	Biological Process	Negative Regulation Of Myeloid Leukocyte Differentiation Purine Nucleotide Metabolic Process Nucleoside Diphosphate Phosphorylation GTP Biosynthetic Process Pyrimidine Nucleotide Metabolic Process UTP Biosynthetic Process CTP Biosynthetic Process Transcription, DNA-templated Regulation Of Transcription, DNA-templated Cell Adhesion Integrin-mediated Signaling Pathway Nucleoside Triphosphate Biosynthetic Process Negative Regulation Of Gene Expression Positive Regulation Of Neuron Projection Development Response To Amine Nucleobase-containing Small Molecule Interconversion Peptidyl-histidine Phosphorylation Hippocampus Development Response To Testosterone Cellular Response To Drug Negative Regulation Of Apoptotic Process Small Molecule Metabolic Process Positive Regulation Of Keratinocyte Differentiation Regulation Of Epidermis Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Epithelial Cell Proliferation Response To CAMP Nucleobase-containing Small Molecule Metabolic Process Cellular Response To Glucose Stimulus Cellular Response To Fatty Acid	Intracellular Protein Transport Endocytosis Blood Coagulation Positive Regulation Of Smooth Muscle Cell Migration Regulation Of Endocytosis Rab Protein Signal Transduction Synaptic Vesicle Recycling Early Endosome To Late Endosome Transport Positive Regulation Of Exocytosis Regulation Of Long-term Neuronal Synaptic Plasticity Positive Regulation Of Smooth Muscle Cell Proliferation Regulation Of Endosome Size Regulation Of Filopodium Assembly Receptor Internalization Involved In Canonical Wnt Signaling Pathway Regulation Of Synaptic Vesicle Exocytosis
Pathways		Metabolism of nucleotides Synthesis and interconversion of nucleotide di- and triphosphates	Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS		Height ( 20881960)
Protein-Protein Interactions		20 interactors: BNIPL CTBP1 DNM1 GIT2 HERC3 HERC5 HERC6 MOB4 NME1 NME1-NME2 NME3 NME4 PPP2CA RAB5A RORA RORB SVIL TBXA2R TERF1 VIM	41 interactors: AGTR1 ALS2CL ANKFY1 AP1G1 AP1G2 APPL1 APPL2 CHM CHML EEA1 GDI2 GGA1 GGA2 GGA3 GRIK4 ITSN1 NME2 OCRL RAB37 RAB7A RABAC1 RABEP1 RABEP2 RABGGTB RASA1 RBSN RIN1 RIN2 RIN3 RIT2 RUFY1 SDCBP SGSM3 STX4 SUN2 TBC1D15 TBC1D17 TBC1D3C TBC1D3F TSC2 USP6NL
Entrez ID		4831	5868
HPRD ID		01132	01542
Ensembl ID		ENSG00000243678	ENSG00000144566
Uniprot IDs		P22392 Q6FHN3	B4DJA5 P20339
PDB IDs		1NSK 1NUE 3BBB 3BBC 3BBF	1N6H 1N6I 1N6K 1N6L 1N6N 1N6O 1N6P 1N6R 1R2Q 1TU3 1TU4 3MJH
Enriched GO Terms of Interacting Partners?		GTP Biosynthetic Process UTP Biosynthetic Process GTP Metabolic Process UTP Metabolic Process CTP Biosynthetic Process Nucleoside Diphosphate Phosphorylation Pyrimidine Ribonucleotide Biosynthetic Process Pyrimidine Nucleoside Biosynthetic Process Pyrimidine Nucleotide Biosynthetic Process Nucleotide Phosphorylation Nucleoside Diphosphate Metabolic Process Pyrimidine Nucleoside Metabolic Process Pyrimidine Nucleotide Metabolic Process Nucleoside Triphosphate Biosynthetic Process Ribonucleotide Metabolic Process Purine Nucleotide Metabolic Process Ribose Phosphate Metabolic Process Purine Nucleotide Biosynthetic Process Ribose Phosphate Biosynthetic Process Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Purine Nucleoside Metabolic Process Nucleotide Metabolic Process Nucleobase-containing Small Molecule Interconversion Nucleoside Metabolic Process Nucleotide Biosynthetic Process Nucleobase-containing Small Molecule Metabolic Process Negative Regulation Of Cell Differentiation Cellular Macromolecule Catabolic Process Receptor Internalization Thromboxane A2 Signaling Pathway Negative Regulation Of Transcription From RNA Polymerase II Promoter By Histone Modification Organophosphate Metabolic Process Regulation Of Cellular Process Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Developmental Process Receptor Metabolic Process Receptor Internalization Involved In Canonical Wnt Signaling Pathway Regulation Of Endosome Size Regulation Of Growth Rate Telomeric Loop Formation Age-dependent Telomere Shortening Negative Regulation Of Chromosome Organization Regulation Of Circadian Rhythm Cerebellar Granule Cell Precursor Proliferation Telomere Maintenance Via Telomere Shortening Steroid Hormone Mediated Signaling Pathway Regulation Of Cellular Component Organization Cell Differentiation Cell Proliferation In Hindbrain Negative Regulation Of Tyrosine Phosphorylation Of Stat3 Protein	Positive Regulation Of GTPase Activity Regulation Of GTPase Activity Positive Regulation Of Hydrolase Activity Vesicle-mediated Transport Positive Regulation Of Catalytic Activity Positive Regulation Of Ras GTPase Activity Regulation Of Ras GTPase Activity Positive Regulation Of Rab GTPase Activity Regulation Of Rab GTPase Activity Regulation Of Rab Protein Signal Transduction Regulation Of Catalytic Activity Regulation Of Ras Protein Signal Transduction Positive Regulation Of Metabolic Process Regulation Of Small GTPase Mediated Signal Transduction Protein Transport Protein Localization Establishment Of Protein Localization Establishment Of Localization In Cell Intracellular Transport Transport Cellular Localization Endocytosis Intracellular Protein Transport Regulation Of Intracellular Signal Transduction Small GTPase Mediated Signal Transduction Endosomal Transport Regulation Of Signaling Regulation Of Signal Transduction Membrane Organization Cellular Protein Localization Protein Geranylgeranylation Regulation Of Vesicle-mediated Transport Regulation Of Metabolic Process Vesicle Fusion Membrane Fusion Positive Regulation Of Exocytosis Protein Prenylation Regulation Of Exocytosis Organelle Fusion Golgi To Lysosome Transport Vesicle Organization Intracellular Signal Transduction Ras Protein Signal Transduction Lysosomal Transport Golgi To Vacuole Transport Plasma Membrane To Endosome Transport Cytoplasmic Transport Signaling Positive Regulation Of Exosomal Secretion Regulation Of Exosomal Secretion
Tagcloud ?		17q12 anonymous brca1 cloning colia1 d17s183 dinucleotide edh17b exclude excludes families heterozygosity hox2 inherited locale ngfr nme1 ovarian phb pinpoint polymorphisms positional q21 rara recombination resolving scg43 thra1 wnt3	accelerated anchored apposing confer directionality effectors endomembrane endosomal enigmatic exactly golgi gtpases liposomes localize master membrane organelles rab2a rab7a rabs reconstitution representative reversible strictly strikingly tethering tethers thoroughly
Tagcloud (Difference) ?		17q12 anonymous brca1 cloning colia1 d17s183 dinucleotide edh17b exclude excludes families heterozygosity hox2 inherited locale ngfr nme1 ovarian phb pinpoint polymorphisms positional q21 rara recombination resolving scg43 thra1 wnt3	accelerated anchored apposing confer directionality effectors endomembrane endosomal enigmatic exactly golgi gtpases liposomes localize master membrane organelles rab2a rab7a rabs reconstitution representative reversible strictly strikingly tethering tethers thoroughly
Tagcloud (Intersection) ?