TBK1 and STX11

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		TBK1	STX11
Gene Name		TANK-binding kinase 1	syntaxin 11
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol Endosome Membrane	Golgi Apparatus Plasma Membrane Synaptic Vesicle Endomembrane System Integral Component Of Membrane SNARE Complex
	Molecular Function	Nucleic Acid Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Phosphoprotein Binding	SNARE Binding SNAP Receptor Activity Protein Binding
	Biological Process	Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Protein Phosphorylation Inflammatory Response I-kappaB Kinase/NF-kappaB Signaling Response To Virus Negative Regulation Of Gene Expression Viral Process Negative Regulation Of Type I Interferon Production Positive Regulation Of Type I Interferon Production Type I Interferon Production Positive Regulation Of Interferon-alpha Production Positive Regulation Of Interferon-beta Production Positive Regulation Of Peptidyl-serine Phosphorylation Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Dendritic Cell Proliferation Innate Immune Response Positive Regulation Of Interferon-beta Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Defense Response To Gram-positive Bacterium Defense Response To Virus	Intracellular Protein Transport Synaptic Vesicle Fusion To Presynaptic Membrane Neutrophil Degranulation Cytotoxic T Cell Degranulation Natural Killer Cell Degranulation Vesicle Docking Membrane Fusion
Pathways		Negative regulators of RIG-I/MDA5 signaling TRIF-mediated TLR3/TLR4 signaling Cytosolic sensors of pathogen-associated DNA MyD88-independent cascade Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon Activated TLR4 signalling RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways TRAF3-dependent IRF activation pathway Toll-Like Receptors Cascades ZBP1(DAI) mediated induction of type I IFNs Regulation of innate immune responses to cytosolic DNA IRF3 mediated activation of type 1 IFN Toll Like Receptor 3 (TLR3) Cascade Toll Like Receptor 4 (TLR4) Cascade STING mediated induction of host immune responses TRAF6 mediated IRF7 activation IRF3-mediated induction of type I IFN STAT6-mediated induction of chemokines Innate Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		38 interactors: AGO2 APP ATG9A AZI2 CALCOCO2 CDC37 CDC42BPG HSP90AA1 HSP90AB1 IKBKB IKBKE IKBKG IRF3 IRF5 IRF7 MAVS MBP MIB1 MIB2 MTPAP NCK1 NEDD4 NFKBIA OPTN PELI1 PROS1 RELA SIKE1 STX11 TANK TICAM1 TRAF2 TRAF3 TRAF3IP2 TRIM27 TXLNA TXLNG XIAP	62 interactors: AES APP BLOC1S6 BYSL C1orf109 CARD9 CCBE1 CCDC184 CCDC33 CCNK CDCA7L CTBP2 CWF19L2 EIF1AD FAM110A FAM161A FAM74A4 FAM90A1 FARS2 FHL5 GOLGA8EP GOLGA8F HAUS1 IKBKG IKZF3 KAT5 KCTD9 KDM1A KLC3 KXD1 LENG1 LONRF1 MBIP MEOX2 MFAP1 MID2 NDC80 PPP1R18 PRKAB2 PRPF31 PSMA3 PSMC3 RUNX1T1 SH2D4A SLC38A2 SMARCE1 SNAP23 SNAP25 SNX3 STXBP1 SUV39H1 TAF6L TBK1 TCF4 TNFRSF21 USHBP1 VAMP2 VPS52 WDYHV1 ZCCHC10 ZNF417 ZNF587
Entrez ID		29110	8676
HPRD ID		05322	09231
Ensembl ID		ENSG00000183735
Uniprot IDs		Q9UHD2	O75558
PDB IDs		4EFO 4EUT 4EUU 4IM0 4IM2 4IM3 4IW0 4IWO 4IWP 4IWQ
Enriched GO Terms of Interacting Partners?		Innate Immune Response Immune Response Defense Response Immune System Process Regulation Of Innate Immune Response Toll-like Receptor 4 Signaling Pathway Regulation Of Immune Response Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction TRIF-dependent Toll-like Receptor Signaling Pathway Activation Of Innate Immune Response MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Positive Regulation Of Innate Immune Response Regulation Of Type I Interferon Production Response To Stress Regulation Of Immune System Process Positive Regulation Of Immune Response Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Cytokine Production Positive Regulation Of Type I Interferon Production Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Cell Communication Positive Regulation Of Immune System Process Positive Regulation Of Cytokine Production Intracellular Receptor Signaling Pathway Signaling Response To Stimulus I-kappaB Kinase/NF-kappaB Signaling Signal Transduction Regulation Of Interferon-beta Production Response To Other Organism Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Response To Biotic Stimulus Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Positive Regulation Of Interferon-beta Production Response To External Stimulus Toll-like Receptor 9 Signaling Pathway Cellular Response To Stimulus Regulation Of Signal Transduction Regulation Of Protein Metabolic Process Response To DsRNA Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Intracellular Signal Transduction Regulation Of Type I Interferon-mediated Signaling Pathway Regulation Of Signaling	Neurotransmitter Secretion Glutamate Secretion Vesicle Localization Regulation Of Neurotransmitter Levels Neurotransmitter Transport Gene Expression Organelle Localization Synaptic Vesicle Transport Establishment Of Vesicle Localization Establishment Of Organelle Localization Vesicle Organization Synaptic Vesicle Exocytosis Acid Secretion Energy Reserve Metabolic Process RNA Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Binding Dicarboxylic Acid Transport Organelle Organization Membrane Docking Transcription, DNA-templated Negative Regulation Of Cellular Metabolic Process Exocytosis RNA Biosynthetic Process Regulation Of Nucleic Acid-templated Transcription Secretion By Cell Regulation Of RNA Biosynthetic Process Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Negative Regulation Of RNA Biosynthetic Process Regulation Of Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Signaling Regulation Of RNA Metabolic Process Viral Process Synaptic Vesicle Docking Membrane Fusion Axon Cargo Transport Synaptic Vesicle Priming Regulation Of Nitrogen Compound Metabolic Process Establishment Of Localization In Cell Vesicle Fusion Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Cellular Macromolecule Biosynthetic Process Generation Of Precursor Metabolites And Energy Synaptic Vesicle Fusion To Presynaptic Membrane Regulation Of Protein Binding Negative Regulation Of Canonical Wnt Signaling Pathway Macromolecule Biosynthetic Process Cellular Localization
Tagcloud ?		associates bax besides characterizes chemokines cytochrome cytosol dispensable hsp90 ikki immediate indispensable initiates initiating irf3 leakage mitochondrion onto outer recruits relocation restrain restrict sacrifice sendai sev tom70 triggers uncovers	autosomal characterised defect done dysregulation familial families fhl haemophagocytic harbour harbouring killer leukaemia lymphohistiocytosis milder mutational myelogenous nonsense perforin periods prf1 psychomotor recessive retardation segregation syntaxin uncommon undertaken unrelated
Tagcloud (Difference) ?		associates bax besides characterizes chemokines cytochrome cytosol dispensable hsp90 ikki immediate indispensable initiates initiating irf3 leakage mitochondrion onto outer recruits relocation restrain restrict sacrifice sendai sev tom70 triggers uncovers	autosomal characterised defect done dysregulation familial families fhl haemophagocytic harbour harbouring killer leukaemia lymphohistiocytosis milder mutational myelogenous nonsense perforin periods prf1 psychomotor recessive retardation segregation syntaxin uncommon undertaken unrelated
Tagcloud (Intersection) ?