TBK1 and MTPAP

Number of citations of the paper that reports this interaction (PMID 21903422)
33

Data Source:
BioGRID (affinity chromatography technology, pull down)

		TBK1	MTPAP
Gene Name		TANK-binding kinase 1	mitochondrial poly(A) polymerase
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol Endosome Membrane	Mitochondrion Intracellular Membrane-bounded Organelle
	Molecular Function	Nucleic Acid Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Phosphoprotein Binding	Magnesium Ion Binding UTP Binding Polynucleotide Adenylyltransferase Activity Protein Binding ATP Binding Manganese Ion Binding Identical Protein Binding Protein Homodimerization Activity Poly(A) RNA Binding
	Biological Process	Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Protein Phosphorylation Inflammatory Response I-kappaB Kinase/NF-kappaB Signaling Response To Virus Negative Regulation Of Gene Expression Viral Process Negative Regulation Of Type I Interferon Production Positive Regulation Of Type I Interferon Production Type I Interferon Production Positive Regulation Of Interferon-alpha Production Positive Regulation Of Interferon-beta Production Positive Regulation Of Peptidyl-serine Phosphorylation Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Dendritic Cell Proliferation Innate Immune Response Positive Regulation Of Interferon-beta Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Defense Response To Gram-positive Bacterium Defense Response To Virus	Transcription, DNA-templated MRNA Polyadenylation Histone MRNA Catabolic Process
Pathways		Negative regulators of RIG-I/MDA5 signaling TRIF-mediated TLR3/TLR4 signaling Cytosolic sensors of pathogen-associated DNA MyD88-independent cascade Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon Activated TLR4 signalling RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways TRAF3-dependent IRF activation pathway Toll-Like Receptors Cascades ZBP1(DAI) mediated induction of type I IFNs Regulation of innate immune responses to cytosolic DNA IRF3 mediated activation of type 1 IFN Toll Like Receptor 3 (TLR3) Cascade Toll Like Receptor 4 (TLR4) Cascade STING mediated induction of host immune responses TRAF6 mediated IRF7 activation IRF3-mediated induction of type I IFN STAT6-mediated induction of chemokines Innate Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		38 interactors: AGO2 APP ATG9A AZI2 CALCOCO2 CDC37 CDC42BPG HSP90AA1 HSP90AB1 IKBKB IKBKE IKBKG IRF3 IRF5 IRF7 MAVS MBP MIB1 MIB2 MTPAP NCK1 NEDD4 NFKBIA OPTN PELI1 PROS1 RELA SIKE1 STX11 TANK TICAM1 TRAF2 TRAF3 TRAF3IP2 TRIM27 TXLNA TXLNG XIAP	3 interactors: AZI2 CALCOCO2 TBK1
Entrez ID		29110	55149
HPRD ID		05322	15097
Ensembl ID		ENSG00000183735	ENSG00000107951
Uniprot IDs		Q9UHD2	Q9NVV4
PDB IDs		4EFO 4EUT 4EUU 4IM0 4IM2 4IM3 4IW0 4IWO 4IWP 4IWQ	3PQ1
Enriched GO Terms of Interacting Partners?		Innate Immune Response Immune Response Defense Response Immune System Process Regulation Of Innate Immune Response Toll-like Receptor 4 Signaling Pathway Regulation Of Immune Response Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction TRIF-dependent Toll-like Receptor Signaling Pathway Activation Of Innate Immune Response MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Positive Regulation Of Innate Immune Response Regulation Of Type I Interferon Production Response To Stress Regulation Of Immune System Process Positive Regulation Of Immune Response Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Cytokine Production Positive Regulation Of Type I Interferon Production Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Cell Communication Positive Regulation Of Immune System Process Positive Regulation Of Cytokine Production Intracellular Receptor Signaling Pathway Signaling Response To Stimulus I-kappaB Kinase/NF-kappaB Signaling Signal Transduction Regulation Of Interferon-beta Production Response To Other Organism Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Response To Biotic Stimulus Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Positive Regulation Of Interferon-beta Production Response To External Stimulus Toll-like Receptor 9 Signaling Pathway Cellular Response To Stimulus Regulation Of Signal Transduction Regulation Of Protein Metabolic Process Response To DsRNA Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Intracellular Signal Transduction Regulation Of Type I Interferon-mediated Signaling Pathway Regulation Of Signaling	Dendritic Cell Proliferation Type I Interferon Production I-kappaB Kinase/NF-kappaB Signaling Lymphocyte Proliferation Mononuclear Cell Proliferation Leukocyte Proliferation Cytokine Production Tumor Necrosis Factor Production Interferon-alpha Production Interleukin-6 Production Immune System Process Positive Regulation Of Interferon-beta Biosynthetic Process Lymphocyte Activation Leukocyte Activation Viral Process Interferon-gamma Production Cell Activation Positive Regulation Of Interferon-alpha Production Cell Proliferation Positive Regulation Of Interferon-beta Production Innate Immune Response Dendritic Cell Differentiation Regulation Of Interferon-beta Production Negative Regulation Of Type I Interferon Production TRIF-dependent Toll-like Receptor Signaling Pathway Defense Response To Gram-positive Bacterium Positive Regulation Of Cytokine Biosynthetic Process MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Immune Response Defense Response Positive Regulation Of Type I Interferon Production Positive Regulation Of Peptidyl-serine Phosphorylation Toll-like Receptor 4 Signaling Pathway
Tagcloud ?		associates bax besides characterizes chemokines cytochrome cytosol dispensable hsp90 ikki immediate indispensable initiates initiating irf3 leakage mitochondrion onto outer recruits relocation restrain restrict sacrifice sendai sev tom70 triggers uncovers
Tagcloud (Difference) ?		associates bax besides characterizes chemokines cytochrome cytosol dispensable hsp90 ikki immediate indispensable initiates initiating irf3 leakage mitochondrion onto outer recruits relocation restrain restrict sacrifice sendai sev tom70 triggers uncovers
Tagcloud (Intersection) ?