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TBK1 and IRF7
Number of citations of the paper that reports this interaction (PubMedID
17599067
)
43
Data Source:
BioGRID
(pull down)
TBK1
IRF7
Description
TANK binding kinase 1
interferon regulatory factor 7
Image
GO Annotations
Cellular Component
Nucleoplasm
Cytoplasm
Cytosol
Serine/threonine Protein Kinase Complex
Chromatin
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Endosome Membrane
Molecular Function
Nucleotide Binding
Nucleic Acid Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Kinase Activity
Transferase Activity
Protein Phosphatase Binding
Identical Protein Binding
Phosphoprotein Binding
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Protein Serine Kinase Activity
Transcription Cis-regulatory Region Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Cis-regulatory Region Sequence-specific DNA Binding
DNA Binding
DNA-binding Transcription Factor Activity
Protein Binding
Sequence-specific Double-stranded DNA Binding
Biological Process
Cytoplasmic Translation
Activation Of Innate Immune Response
Immune System Process
Cytoplasmic Pattern Recognition Receptor Signaling Pathway
Protein Phosphorylation
Protein Import Into Nucleus
Inflammatory Response
Canonical NF-kappaB Signal Transduction
MRNA Transcription
Response To Virus
Regulation Of Gene Expression
Positive Regulation Of Autophagy
Negative Regulation Of Gene Expression
Macroautophagy
Positive Regulation Of Macroautophagy
Peptidyl-serine Phosphorylation
Peptidyl-threonine Phosphorylation
Regulation Of Metabolic Process
Signal Transduction Involved In Regulation Of Gene Expression
Cellular Response To Nutrient Levels
Positive Regulation Of TOR Signaling
Regulation Of Type I Interferon Production
Negative Regulation Of Type I Interferon Production
Positive Regulation Of Type I Interferon Production
Positive Regulation Of Interferon-alpha Production
Positive Regulation Of Interferon-beta Production
Toll-like Receptor 4 Signaling Pathway
TORC1 Signaling
TORC2 Signaling
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Dendritic Cell Proliferation
Innate Immune Response
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Translational Initiation
Defense Response To Gram-positive Bacterium
Defense Response To Virus
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Type I Interferon-mediated Signaling Pathway
Positive Regulation Of Type I Interferon-mediated Signaling Pathway
T Follicular Helper Cell Differentiation
Defense Response To Other Organism
Antiviral Innate Immune Response
CGAS/STING Signaling Pathway
Positive Regulation Of Cytokine Production Involved In Inflammatory Response
Negative Regulation Of TORC1 Signaling
Positive Regulation Of TORC1 Signaling
Positive Regulation Of Xenophagy
Positive Regulation Of TORC2 Signaling
Negative Regulation Of Transcription By RNA Polymerase II
Immune System Process
Cytoplasmic Pattern Recognition Receptor Signaling Pathway
Regulation Of Adaptive Immune Response
Regulation Of DNA-templated Transcription
Regulation Of Transcription By RNA Polymerase II
DNA Damage Response
Signal Transduction
Response To Virus
Regulation Of Gene Expression
Immunoglobulin Mediated Immune Response
Establishment Of Viral Latency
Regulation Of Type I Interferon Production
Positive Regulation Of Type I Interferon Production
Positive Regulation Of Interferon-alpha Production
Positive Regulation Of Interferon-beta Production
Regulation Of MyD88-dependent Toll-like Receptor Signaling Pathway
Regulation Of MyD88-independent Toll-like Receptor Signaling Pathway
MDA-5 Signaling Pathway
Innate Immune Response
Positive Regulation Of Innate Immune Response
Regulation Of Monocyte Differentiation
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Immune Response
Defense Response To Virus
Type I Interferon-mediated Signaling Pathway
Positive Regulation Of Type I Interferon-mediated Signaling Pathway
Negative Regulation Of Macrophage Apoptotic Process
Pathways
IRF3 mediated activation of type 1 IFN
IRF3 mediated activation of type 1 IFN
DDX58/IFIH1-mediated induction of interferon-alpha/beta
Regulation of innate immune responses to cytosolic DNA
STAT6-mediated induction of chemokines
IRF3-mediated induction of type I IFN
PINK1-PRKN Mediated Mitophagy
TNFR1-induced proapoptotic signaling
Regulation of TNFR1 signaling
Interleukin-37 signaling
TICAM1-dependent activation of IRF3/IRF7
TRAF3-dependent IRF activation pathway
TRAF6 mediated IRF7 activation
Negative regulators of DDX58/IFIH1 signaling
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE)
Potential therapeutics for SARS
SARS-CoV-1 activates/modulates innate immune responses
SARS-CoV-2 activates/modulates innate and adaptive immune responses
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation
DEx/H-box helicases activate type I IFN and inflammatory cytokines production
Interferon gamma signaling
TICAM1-dependent activation of IRF3/IRF7
Interferon alpha/beta signaling
TRAF3-dependent IRF activation pathway
TRAF6 mediated IRF7 activation
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE)
SARS-CoV-2 activates/modulates innate and adaptive immune responses
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
Drugs
Fostamatinib
Diseases
GWAS
Amyotrophic lateral sclerosis (
27455348
29566793
)
High light scatter reticulocyte count (
32888494
)
High light scatter reticulocyte percentage of red cells (
32888494
)
Lung adenocarcinoma (
28604730
)
Reticulocyte count (
32888494
)
Reticulocyte fraction of red cells (
32888494
)
Systemic lupus erythematosus (
26502338
27399966
28714469
)
Systemic lupus erythematosus and Systemic sclerosis (
23740937
)
Systemic sclerosis (
31672989
)
Interacting Genes
47 interacting genes:
AGO2
APP
ATG9A
AZI2
CDC20
CDC37
CDC42BPG
CRTC1
CYLD
FZR1
HSP90AA1
HSP90AB1
IKBKB
IKBKG
IRF3
IRF5
IRF7
LMO7
MAVS
MBP
MIB2
MTPAP
NCK1
NFKBIA
PROS1
PTPRD
RELA
RIPK1
RNF128
RPS6KB1
SIKE1
SMCR8
SMURF1
STX11
TANK
TICAM1
TNIP1
TRAF2
TRAF3
TRAF3IP2
TRAF5
TRIM21
TXLNG
UBC
UBQLN2
VHL
XIAP
27 interacting genes:
ACADS
AIP
ARAF
CCDC47
CREBBP
EP300
GCLM
INSR
IRAK1
IRF3
KAT2A
KAT2B
LTN1
MAVS
MYD88
PALD1
PIAS4
SOCS1
SOCS3
TBK1
TICAM1
TICAM2
TLK2
TP53
TRAF6
TRIM28
TRMT61B
Entrez ID
29110
3665
HPRD ID
05322
05441
Ensembl ID
ENSG00000183735
ENSG00000185507
Uniprot IDs
Q9UHD2
B4E1B1
M9RSF4
Q92985
PDB IDs
4EFO
4EUT
4EUU
4IM0
4IM2
4IM3
4IW0
4IWO
4IWP
4IWQ
5EOA
5EOF
5EP6
5W5V
6BNY
6BOD
6BOE
6CQ0
6CQ4
6CQ5
6NT9
6O8B
6RSR
6RST
6RSU
2O61
Enriched GO Terms of Interacting Partners
?
Regulation Of Canonical NF-kappaB Signal Transduction
Regulation Of Type I Interferon Production
Positive Regulation Of Metabolic Process
Activation Of Innate Immune Response
Pattern Recognition Receptor Signaling Pathway
Positive Regulation Of Protein Metabolic Process
Regulation Of Cytokine Production
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Innate Immune Response-activating Signaling Pathway
Regulation Of Immune Response
Regulation Of Innate Immune Response
Regulation Of Cytokine-mediated Signaling Pathway
Positive Regulation Of Macromolecule Metabolic Process
Cytoplasmic Pattern Recognition Receptor Signaling Pathway
Regulation Of Signaling
Regulation Of Signal Transduction
Cytokine-mediated Signaling Pathway
Activation Of Immune Response
Immune Response-activating Signaling Pathway
Defense Response
Regulation Of Protein Metabolic Process
Positive Regulation Of Defense Response
Positive Regulation Of Innate Immune Response
Regulation Of Cell Communication
Positive Regulation Of Type I Interferon Production
Regulation Of DNA-binding Transcription Factor Activity
Canonical NF-kappaB Signal Transduction
Regulation Of Interferon-beta Production
Response To Virus
Tumor Necrosis Factor-mediated Signaling Pathway
Response To External Biotic Stimulus
Cytosol
Immune Response-regulating Signaling Pathway
Signal Transduction Involved In Regulation Of Gene Expression
Negative Regulation Of Canonical NF-kappaB Signal Transduction
Regulation Of Defense Response
Regulation Of Intracellular Signal Transduction
Response To Other Organism
Regulation Of Immune System Process
Positive Regulation Of Biosynthetic Process
Positive Regulation Of Immune Response
Signaling Adaptor Activity
Cytoplasm
Cell Surface Receptor Signaling Pathway
Positive Regulation Of Macromolecule Biosynthetic Process
Regulation Of Macromolecule Metabolic Process
Regulation Of Primary Metabolic Process
Positive Regulation Of Gene Expression
Positive Regulation Of Cytokine Production
Protein Ubiquitination
Innate Immune Response Activating Cell Surface Receptor Signaling Pathway
Innate Immune Response-activating Signaling Pathway
Toll-like Receptor 4 Signaling Pathway
Activation Of Innate Immune Response
Cell Surface Toll-like Receptor Signaling Pathway
Positive Regulation Of Type I Interferon Production
Cell Surface Pattern Recognition Receptor Signaling Pathway
Positive Regulation Of Innate Immune Response
Regulation Of Type I Interferon Production
Regulation Of Canonical NF-kappaB Signal Transduction
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Immune Response-activating Signaling Pathway
Immune Response-activating Cell Surface Receptor Signaling Pathway
Toll-like Receptor Signaling Pathway
Pattern Recognition Receptor Signaling Pathway
Cytoplasmic Pattern Recognition Receptor Signaling Pathway
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Immune Response-regulating Signaling Pathway
Activation Of Immune Response
Regulation Of Innate Immune Response
Interferon-mediated Signaling Pathway
Positive Regulation Of Defense Response
TRIF-dependent Toll-like Receptor Signaling Pathway
Cellular Response To Oxygen-containing Compound
Peptidyl-lysine Acetylation
Histone H3K18 Acetyltransferase Activity
N-terminal Peptidyl-lysine Acetylation
Lipopolysaccharide-mediated Signaling Pathway
Protein Modification Process
MyD88-independent Toll-like Receptor Signaling Pathway
Cellular Response To Lipopolysaccharide
Transferase Activity
Cytokine-mediated Signaling Pathway
Intracellular Signal Transduction
Cellular Response To Molecule Of Bacterial Origin
Acetyltransferase Activity
Type I Interferon-mediated Signaling Pathway
Regulation Of Defense Response
Canonical NF-kappaB Signal Transduction
MRNA Transcription
Macromolecule Metabolic Process
Transcription Coregulator Activity
Positive Regulation Of Immune Response
Histone Acetyltransferase Complex
Intracellular Receptor Signaling Pathway
Protein-lysine-acetyltransferase Activity
Positive Regulation Of Cytokine Production
Cell Surface Receptor Signaling Pathway
Positive Regulation Of Intracellular Signal Transduction
Endolysosomal Toll-like Receptor Signaling Pathway
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