TBK1 and RIPK1

Number of citations of the paper that reports this interaction (PubMedID 30420664)
70

Data Source:
BioGRID (enzymatic study)

		TBK1	RIPK1
Description		TANK binding kinase 1	receptor interacting serine/threonine kinase 1
Image
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Serine/threonine Protein Kinase Complex	Cytoplasm Mitochondrion Cytosol Plasma Membrane Endosome Membrane Membrane Death-inducing Signaling Complex Protein-containing Complex Receptor Complex Ripoptosome
	Molecular Function	Nucleotide Binding Nucleic Acid Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Phosphatase Binding Identical Protein Binding Phosphoprotein Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Protein Serine Kinase Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity JUN Kinase Kinase Kinase Activity Death Receptor Binding Protein Binding ATP Binding Kinase Activity Transferase Activity Ubiquitin Protein Ligase Binding Signaling Adaptor Activity Identical Protein Binding Protein Homodimerization Activity Protein-containing Complex Binding Death Domain Binding Protein Serine Kinase Activity
	Biological Process	Cytoplasmic Translation Activation Of Innate Immune Response Immune System Process Cytoplasmic Pattern Recognition Receptor Signaling Pathway Protein Phosphorylation Protein Import Into Nucleus Inflammatory Response Canonical NF-kappaB Signal Transduction MRNA Transcription Response To Virus Regulation Of Gene Expression Positive Regulation Of Autophagy Negative Regulation Of Gene Expression Macroautophagy Positive Regulation Of Macroautophagy Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Regulation Of Metabolic Process Signal Transduction Involved In Regulation Of Gene Expression Cellular Response To Nutrient Levels Positive Regulation Of TOR Signaling Regulation Of Type I Interferon Production Negative Regulation Of Type I Interferon Production Positive Regulation Of Type I Interferon Production Positive Regulation Of Interferon-alpha Production Positive Regulation Of Interferon-beta Production Toll-like Receptor 4 Signaling Pathway TORC1 Signaling TORC2 Signaling Positive Regulation Of Canonical NF-kappaB Signal Transduction Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Dendritic Cell Proliferation Innate Immune Response Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Translational Initiation Defense Response To Gram-positive Bacterium Defense Response To Virus Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Type I Interferon-mediated Signaling Pathway Positive Regulation Of Type I Interferon-mediated Signaling Pathway T Follicular Helper Cell Differentiation Defense Response To Other Organism Antiviral Innate Immune Response CGAS/STING Signaling Pathway Positive Regulation Of Cytokine Production Involved In Inflammatory Response Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling Positive Regulation Of Xenophagy Positive Regulation Of TORC2 Signaling	MAPK Cascade Positive Regulation Of Protein Phosphorylation Apoptotic Process Inflammatory Response Response To Oxidative Stress Signal Transduction Canonical NF-kappaB Signal Transduction Positive Regulation Of Gene Expression Programmed Cell Death Protein Catabolic Process Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Tumor Necrosis Factor-mediated Signaling Pathway Response To Tumor Necrosis Factor Intracellular Signal Transduction Peptidyl-serine Autophosphorylation Positive Regulation Of Phosphorylation Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of MAPK Cascade Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of Macrophage Differentiation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of JNK Cascade Protein Autophosphorylation Positive Regulation Of Inflammatory Response Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Necroptotic Process Positive Regulation Of Necroptotic Process Negative Regulation Of Necroptotic Process Positive Regulation Of Programmed Necrotic Cell Death Positive Regulation Of Interleukin-6-mediated Signaling Pathway T Cell Apoptotic Process Necroptotic Process Cellular Response To Hydrogen Peroxide Cellular Response To Tumor Necrosis Factor Cellular Response To Growth Factor Stimulus Extrinsic Apoptotic Signaling Pathway Programmed Necrotic Cell Death Ripoptosome Assembly Necroptotic Signaling Pathway Positive Regulation Of Execution Phase Of Apoptosis Ripoptosome Assembly Involved In Necroptotic Process Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of MiRNA Processing Amyloid Fibril Formation Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Reactive Oxygen Species Metabolic Process Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		IRF3 mediated activation of type 1 IFN IRF3 mediated activation of type 1 IFN DDX58/IFIH1-mediated induction of interferon-alpha/beta Regulation of innate immune responses to cytosolic DNA STAT6-mediated induction of chemokines IRF3-mediated induction of type I IFN PINK1-PRKN Mediated Mitophagy TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling Interleukin-37 signaling TICAM1-dependent activation of IRF3/IRF7 TRAF3-dependent IRF activation pathway TRAF6 mediated IRF7 activation Negative regulators of DDX58/IFIH1 signaling Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) Potential therapeutics for SARS SARS-CoV-1 activates/modulates innate immune responses SARS-CoV-2 activates/modulates innate and adaptive immune responses Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation	Caspase activation via Death Receptors in the presence of ligand TICAM1, RIP1-mediated IKK complex recruitment RIP-mediated NFkB activation via ZBP1 TRIF-mediated programmed cell death TRP channels Regulation by c-FLIP RIPK1-mediated regulated necrosis CASP8 activity is inhibited TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NF-kappa-B signaling pathway Regulation of necroptotic cell death Ub-specific processing proteases Ovarian tumor domain proteases Dimerization of procaspase-8 TNF signaling TLR3-mediated TICAM1-dependent programmed cell death NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 IKK complex recruitment mediated by RIP1 Potential therapeutics for SARS Microbial modulation of RIPK1-mediated regulated necrosis SARS-CoV-1-mediated effects on programmed cell death Defective RIPK1-mediated regulated necrosis
Drugs		Fostamatinib	Fostamatinib
Diseases
GWAS		Amyotrophic lateral sclerosis ( 27455348 29566793) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Lung adenocarcinoma ( 28604730) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494)	Cerebral white matter volume ( 31530798) Idiopathic osteonecrosis of the femoral head ( 28000841)
Interacting Genes		47 interacting genes: AGO2 APP ATG9A AZI2 CDC20 CDC37 CDC42BPG CRTC1 CYLD FZR1 HSP90AA1 HSP90AB1 IKBKB IKBKG IRF3 IRF5 IRF7 LMO7 MAVS MBP MIB2 MTPAP NCK1 NFKBIA PROS1 PTPRD RELA RIPK1 RNF128 RPS6KB1 SIKE1 SMCR8 SMURF1 STX11 TANK TICAM1 TNIP1 TRAF2 TRAF3 TRAF3IP2 TRAF5 TRIM21 TXLNG UBC UBQLN2 VHL XIAP	49 interacting genes: ANKRD13A CASP8 CCDC50 CDC42BPB CFLAR CRADD CTNNB1 EGFR FADD FAS HSP90AA1 IKBKE IKBKG ITCH MAP3K14 MAP3K3 MAP3K8 MTDH NFKB1 NUMBL OTUD1 PPDPF PTK2 RIPK3 RNF11 RNF216 RPA1 SQSTM1 TAX1BP1 TBK1 TICAM1 TNF TNFAIP3 TNFRSF10A TNFRSF10B TNFRSF1A TRADD TRAF1 TRAF2 TRAF3 TRAF5 TRAF6 TRIM38 TRIM72 TRPC4AP UBE2N USP21 YOD1 ZFAND5
Entrez ID		29110	8737
HPRD ID		05322	04583
Ensembl ID		ENSG00000183735	ENSG00000137275
Uniprot IDs		Q9UHD2	Q13546
PDB IDs		4EFO 4EUT 4EUU 4IM0 4IM2 4IM3 4IW0 4IWO 4IWP 4IWQ 5EOA 5EOF 5EP6 5W5V 6BNY 6BOD 6BOE 6CQ0 6CQ4 6CQ5 6NT9 6O8B 6RSR 6RST 6RSU	4ITH 4ITI 4ITJ 4NEU 5HX6 5TX5 5V7Z 6AC5 6C3E 6C4D 6HHO 6NW2 6NYH 6OCQ 6R5F 6RLN 7CJB 7FCZ 7FD0 7XMK 7YDX 8I2N
Enriched GO Terms of Interacting Partners?		Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Type I Interferon Production Positive Regulation Of Metabolic Process Activation Of Innate Immune Response Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Protein Metabolic Process Regulation Of Cytokine Production Positive Regulation Of Canonical NF-kappaB Signal Transduction Innate Immune Response-activating Signaling Pathway Regulation Of Immune Response Regulation Of Innate Immune Response Regulation Of Cytokine-mediated Signaling Pathway Positive Regulation Of Macromolecule Metabolic Process Cytoplasmic Pattern Recognition Receptor Signaling Pathway Regulation Of Signaling Regulation Of Signal Transduction Cytokine-mediated Signaling Pathway Activation Of Immune Response Immune Response-activating Signaling Pathway Defense Response Regulation Of Protein Metabolic Process Positive Regulation Of Defense Response Positive Regulation Of Innate Immune Response Regulation Of Cell Communication Positive Regulation Of Type I Interferon Production Regulation Of DNA-binding Transcription Factor Activity Canonical NF-kappaB Signal Transduction Regulation Of Interferon-beta Production Response To Virus Tumor Necrosis Factor-mediated Signaling Pathway Response To External Biotic Stimulus Cytosol Immune Response-regulating Signaling Pathway Signal Transduction Involved In Regulation Of Gene Expression Negative Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Defense Response Regulation Of Intracellular Signal Transduction Response To Other Organism Regulation Of Immune System Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Immune Response Signaling Adaptor Activity Cytoplasm Cell Surface Receptor Signaling Pathway Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of Gene Expression Positive Regulation Of Cytokine Production Protein Ubiquitination	Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Canonical NF-kappaB Signal Transduction Apoptotic Process Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Cell Death Programmed Cell Death Tumor Necrosis Factor-mediated Signaling Pathway Cell Surface Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Regulation Of Apoptotic Process Positive Regulation Of Signal Transduction Regulation Of Programmed Cell Death Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Intracellular Signal Transduction Cellular Response To Mechanical Stimulus Tumor Necrosis Factor Receptor Binding Positive Regulation Of Defense Response Response To Mechanical Stimulus Non-canonical NF-kappaB Signal Transduction Signaling Adaptor Activity Apoptotic Signaling Pathway Signal Transduction Ubiquitin Protein Ligase Binding Regulation Of Signal Transduction Intracellular Signal Transduction Activation Of Immune Response Extrinsic Apoptotic Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Death-inducing Signaling Complex Regulation Of Defense Response Regulation Of Immune Response Response To Virus Positive Regulation Of Immune Response Immune System Process TRAIL-activated Apoptotic Signaling Pathway Cytokine-mediated Signaling Pathway Immune Response-regulating Signaling Pathway Response To External Biotic Stimulus Positive Regulation Of Protein Metabolic Process Regulation Of Signaling Activation Of Innate Immune Response Regulation Of Cell Communication Defense Response Immune Response-activating Signaling Pathway Positive Regulation Of DNA-binding Transcription Factor Activity Response To Other Organism Positive Regulation Of Innate Immune Response Positive Regulation Of Immune System Process Regulation Of Immune System Process
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