ATP1A1 and EZH2

Number of citations of the paper that reports this interaction (PubMedID 36517590)
0

Data Source:
BioGRID (affinity chromatography technology)
HPRD (two hybrid)

		ATP1A1	EZH2
Description		ATPase Na+/K+ transporting subunit alpha 1	enhancer of zeste 2 polycomb repressive complex 2 subunit
Image
GO Annotations	Cellular Component	Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Sodium:potassium-exchanging ATPase Complex Postsynaptic Density Membrane Basolateral Plasma Membrane Apical Plasma Membrane Lateral Plasma Membrane T-tubule Axon Organelle Membrane Protein-containing Complex Sperm Flagellum Sarcolemma Melanosome Cell Projection Membrane Raft Photoreceptor Inner Segment Membrane Extracellular Exosome Extracellular Vesicle	Chromosome, Telomeric Region Chromatin Nucleus Nucleoplasm Chromatin Silencing Complex Chromosome Pericentric Heterochromatin ESC/E(Z) Complex Pronucleus Synapse
	Molecular Function	Nucleotide Binding P-type Sodium:potassium-exchanging Transporter Activity Protein Binding ATP Binding P-type Potassium Transmembrane Transporter Activity Phosphatase Activity ATP Hydrolysis Activity Potassium Ion Binding Sodium Ion Binding Transmembrane Transporter Binding Metal Ion Binding Protein Heterodimerization Activity Protein-folding Chaperone Binding Steroid Hormone Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding Transcription Corepressor Binding DNA Binding Chromatin Binding Transcription Corepressor Activity RNA Binding Protein Binding Methyltransferase Activity Protein-lysine N-methyltransferase Activity Transferase Activity Chromatin DNA Binding Nucleosome Binding Histone Methyltransferase Activity Histone Binding Ribonucleoprotein Complex Binding Sequence-specific DNA Binding Histone H3K27 Methyltransferase Activity Primary MiRNA Binding LncRNA Binding Histone H3 Methyltransferase Activity Histone H3K27 Trimethyltransferase Activity Promoter-specific Chromatin Binding
	Biological Process	Regulation Of The Force Of Heart Contraction Regulation Of Sodium Ion Transport Monoatomic Ion Transport Potassium Ion Transport Sodium Ion Transport Intracellular Sodium Ion Homeostasis Osmosensory Signaling Pathway Regulation Of Blood Pressure Response To Xenobiotic Stimulus Establishment Or Maintenance Of Transmembrane Electrochemical Gradient Intracellular Monoatomic Cation Homeostasis Intracellular Potassium Ion Homeostasis Negative Regulation Of Glucocorticoid Biosynthetic Process Sodium Ion Transmembrane Transport Sodium Ion Export Across Plasma Membrane Negative Regulation Of Heart Contraction Positive Regulation Of Heart Contraction Positive Regulation Of Striated Muscle Contraction Sodium Ion Homeostasis Relaxation Of Cardiac Muscle Heart Contraction Cellular Response To Steroid Hormone Stimulus Potassium Ion Transmembrane Transport Cardiac Muscle Cell Action Potential Involved In Contraction Membrane Repolarization Membrane Repolarization During Cardiac Muscle Cell Action Potential Cell Communication By Electrical Coupling Involved In Cardiac Conduction Proton Transmembrane Transport Response To Glycoside Potassium Ion Import Across Plasma Membrane	G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Chromatin Remodeling DNA Methylation-dependent Constitutive Heterochromatin Formation Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Cell Population Proliferation Epidermal Cell Differentiation Regulation Of Gene Expression Negative Regulation Of Gene Expression Positive Regulation Of Epithelial To Mesenchymal Transition Regulation Of Gliogenesis Skeletal Muscle Satellite Cell Maintenance Involved In Skeletal Muscle Regeneration Cardiac Muscle Hypertrophy In Response To Stress Cerebellar Cortex Development Hippocampus Development Hemopoiesis B Cell Differentiation Keratinocyte Differentiation Positive Regulation Of Cell Migration Regulatory NcRNA-mediated Heterochromatin Formation Heterochromatin Formation Subtelomeric Heterochromatin Formation Methylation Response To Estradiol Negative Regulation Of Transcription Elongation By RNA Polymerase II Cellular Response To Trichostatin A Protein Modification Process Hepatocyte Homeostasis Regulation Of Cell Population Proliferation Regulation Of Circadian Rhythm Positive Regulation Of MAP Kinase Activity Positive Regulation Of GTPase Activity Negative Regulation Of Epidermal Cell Differentiation Negative Regulation Of Keratinocyte Differentiation Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of DNA-templated Transcription Negative Regulation Of Retinoic Acid Receptor Signaling Pathway Rhythmic Process Stem Cell Differentiation Regulation Of Neurogenesis Negative Regulation Of Striated Muscle Cell Differentiation Synaptic Transmission, GABAergic Cellular Response To Hydrogen Peroxide G1 To G0 Transition Protein Localization To Chromatin Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Kidney Development Liver Regeneration Facultative Heterochromatin Formation Positive Regulation Of Dendrite Development Negative Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Cell Cycle G1/S Phase Transition Response To Tetrachloromethane Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Stem Cell Differentiation
Pathways		Ion homeostasis Ion transport by P-type ATPases Potential therapeutics for SARS	PRC2 methylates histones and DNA Oxidative Stress Induced Senescence PKMTs methylate histone lysines Activation of anterior HOX genes in hindbrain development during early embryogenesis Regulation of PTEN gene transcription Regulation of PTEN gene transcription Transcriptional Regulation by E2F6 HCMV Early Events Defective pyroptosis Negative Regulation of CDH1 Gene Transcription Regulation of PD-L1(CD274) transcription
Drugs		Digoxin Acetyldigitoxin Hydroflumethiazide Etacrynic acid Trichlormethiazide Deslanoside Ouabain Diazoxide Bretylium Ciclopirox Bepridil Potassium cation Aluminium Magnesium cation Digitoxin Almitrine Istaroxime Bisacodyl Magnesium acetate Potassium acetate Potassium sulfate Potassium Magnesium levulinate Magnesium lactate Aluminium phosphate Aluminum acetate Tegoprazan	Tazemetostat CPI-1205
Diseases
GWAS		Coffee consumption ( 29367735) HDL cholesterol levels in HIV infection ( 33109212) Hip index ( 34021172) Macular thickness ( 30535121)	Chronotype ( 30696823) Colorectal or endometrial cancer ( 26621817) Crohn's disease ( 28067908) Familial squamous cell lung carcinoma ( 29924316) Height ( 25282103 31562340) Inflammatory bowel disease ( 28067908) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 25673412)
Interacting Genes		21 interacting genes: A2M ADD1 CEBPA CFL1 EGFR EZH2 FNDC3B FXYD1 FXYD2 FXYD7 GPR35 HGS MAPK1 MAPK3 NDRG1 PRKCA RNF10 SNAPIN TPT1 ZNRF1 ZNRF2	87 interacting genes: AKT1 AR ARID1A ATP1A1 ATP1B1 ATRX BCL11A BRCA1 C7orf25 CCDC85B CDK6 CDKN2B-AS1 CEP63 CRY2 DANCR DELEC1 DNAJB11 DNMT1 DNMT3A DNMT3B E2F6 EED EHMT1 EP300 EPC2 FBXW7 GADD45G GTF3C1 H1-1 H2AC4 H3-4 H3C1 HAT1 HDAC1 HOTAIR HOXA11-AS JAK2 KAT2B KLHDC2 KRTAP10-9 LATS2 LINC00511 MAP3K20 MAP3K7 MAPK8IP2 MAPKAPK3 MED1 MELK MUC1 NINL PFDN1 PHB2 PHF1 PIN4 PJA1 POLA2 PRDM14 PRMT5 PSMB6 RASA1 RBL2 RCN3 RELA RELB RIN3 RPN2 RPS6KA5 SIRT1 SKIC8 SMARCA4 SMARCB1 SMN1 SMS SMYD3 SUV39H1 SUZ12 TAF1D TK1 TNFSF11 TRIM55 TRIM63 TSPYL2 UCA1 USP1 VAV1 WSB2 ZMYND11
Entrez ID		476	2146
HPRD ID		01662	03342
Ensembl ID		ENSG00000163399	ENSG00000106462
Uniprot IDs		P05023	A0A090N8E9 F2YMM1 Q15910 S4S3R8
PDB IDs		7E1Z 7E20 7E21	4MI0 4MI5 5GSA 5H14 5H15 5H17 5H19 5H24 5H25 5HYN 5IJ7 5IJ8 5LS6 5U5T 5U62 5WG6 5WUK 6C23 6C24 6LO2 6P5L 6U4Y 6WKR 7AT8 7QJG 7QJU 7QK4 8EQV 8FYH 8T9G 8TAS 8TB9 8VMI 8VML 8VNV 8VNZ 9C8U 9DCH
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Sodium Ion Export Across Plasma Membrane Ion Channel Regulator Activity Response To Epidermal Growth Factor Regulation Of Transport Positive Regulation Of Sodium Ion Transmembrane Transport Positive Regulation Of Autophagosome-lysosome Fusion ERBB2 Signaling Pathway Regulation Of Vesicle-mediated Transport Positive Regulation Of Transport Interleukin-34-mediated Signaling Pathway Cellular Response To Tumor Necrosis Factor Sodium Channel Regulator Activity Intracellular Monoatomic Ion Homeostasis Regulation Of Cell Population Proliferation Positive Regulation Of Sodium Ion Transport Intracellular Monoatomic Cation Homeostasis Negative Regulation Of Developmental Process Regulation Of Golgi Inheritance Regulation Of Sodium Ion Transmembrane Transport Response To Tumor Necrosis Factor Caveolin-mediated Endocytosis Positive Regulation Of Macrophage Proliferation Monoatomic Cation Homeostasis Monoatomic Ion Homeostasis Cardiac Neural Crest Cell Development Involved In Heart Development Trachea Formation Positive Regulation Of Cellular Component Organization Intracellular Chemical Homeostasis Regulation Of Protein Metabolic Process Chemical Homeostasis Positive Regulation Of Cell Motility Outer Ear Morphogenesis ERBB3 Signaling Pathway ERBB2-ERBB3 Signaling Pathway Sodium Ion Transport Positive Regulation Of Locomotion Epidermal Growth Factor Receptor Signaling Pathway Bergmann Glial Cell Differentiation Sodium:potassium-exchanging ATPase Complex Regulation Of Sodium Ion Transport Homeostatic Process Cellular Homeostasis Caveola ERBB Signaling Pathway Negative Regulation Of Cell Differentiation Focal Adhesion Morphogenesis Of An Epithelial Fold Regulation Of Cellular PH MAP Kinase Activity Regulation Of Golgi Organization	Chromatin Organization Epigenetic Regulation Of Gene Expression Chromatin Remodeling Negative Regulation Of Metabolic Process Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Heterochromatin Formation Negative Regulation Of Gene Expression Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Nucleoplasm Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process P53 Binding Nucleus Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Nucleosome Organization Regulation Of Macromolecule Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Regulation Of Primary Metabolic Process Facultative Heterochromatin Formation Protein-containing Complex Heterochromatin Regulation Of DNA-templated Transcription Regulation Of Cellular Response To Stress Regulation Of Cell Cycle Negative Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Constitutive Heterochromatin Formation Chromatin Binding Intracellular Signal Transduction Regulation Of RNA Metabolic Process Protein-DNA Complex Assembly Chromosome Transferase Activity Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Multicellular Organismal Process DNA (cytosine-5-)-methyltransferase Activity Chromatin Silencing Complex Negative Regulation Of Cell Cycle DNA Binding Protein Modification Process Chromatin DNA Binding Positive Regulation Of Gene Expression
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