ATP1A1

Name	ATPase Na+/K+ transporting subunit alpha 1
Structure
Interactors	21 interactors: A2M ADD1 CEBPA CFL1 EGFR EZH2 FNDC3B FXYD1 FXYD2 FXYD7 GPR35 HGS MAPK1 MAPK3 NDRG1 PRKCA RNF10 SNAPIN TPT1 ZNRF1 ZNRF2
GO Annotations	Cellular Component	Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Sodium:potassium-exchanging ATPase Complex Postsynaptic Density Membrane Basolateral Plasma Membrane Apical Plasma Membrane Lateral Plasma Membrane T-tubule Axon Organelle Membrane Protein-containing Complex Sperm Flagellum Sarcolemma Melanosome Cell Projection Membrane Raft Photoreceptor Inner Segment Membrane Extracellular Exosome Extracellular Vesicle
	Molecular Function	Nucleotide Binding P-type Sodium:potassium-exchanging Transporter Activity Protein Binding ATP Binding P-type Potassium Transmembrane Transporter Activity Phosphatase Activity ATP Hydrolysis Activity Potassium Ion Binding Sodium Ion Binding Transmembrane Transporter Binding Metal Ion Binding Protein Heterodimerization Activity Protein-folding Chaperone Binding Steroid Hormone Binding
	Biological Process	Regulation Of The Force Of Heart Contraction Regulation Of Sodium Ion Transport Monoatomic Ion Transport Potassium Ion Transport Sodium Ion Transport Intracellular Sodium Ion Homeostasis Osmosensory Signaling Pathway Regulation Of Blood Pressure Response To Xenobiotic Stimulus Establishment Or Maintenance Of Transmembrane Electrochemical Gradient Intracellular Monoatomic Cation Homeostasis Intracellular Potassium Ion Homeostasis Negative Regulation Of Glucocorticoid Biosynthetic Process Sodium Ion Transmembrane Transport Sodium Ion Export Across Plasma Membrane Negative Regulation Of Heart Contraction Positive Regulation Of Heart Contraction Positive Regulation Of Striated Muscle Contraction Sodium Ion Homeostasis Relaxation Of Cardiac Muscle Heart Contraction Cellular Response To Steroid Hormone Stimulus Potassium Ion Transmembrane Transport Cardiac Muscle Cell Action Potential Involved In Contraction Membrane Repolarization Membrane Repolarization During Cardiac Muscle Cell Action Potential Cell Communication By Electrical Coupling Involved In Cardiac Conduction Proton Transmembrane Transport Response To Glycoside Potassium Ion Import Across Plasma Membrane
Pathways	Ion homeostasis Ion transport by P-type ATPases Potential therapeutics for SARS
Drugs	Digoxin Acetyldigitoxin Hydroflumethiazide Etacrynic acid Trichlormethiazide Deslanoside Ouabain Diazoxide Bretylium Ciclopirox Bepridil Potassium cation Aluminium Magnesium cation Digitoxin Almitrine Istaroxime Bisacodyl Magnesium acetate Potassium acetate Potassium sulfate Potassium Magnesium levulinate Magnesium lactate Aluminium phosphate Aluminum acetate Tegoprazan
GWAS	Coffee consumption ( 29367735 ) HDL cholesterol levels in HIV infection ( 33109212 ) Hip index ( 34021172 ) Macular thickness ( 30535121 )
Entrez ID	476
HPRD ID	01662
Ensembl ID	ENSG00000163399
Uniprot IDs	P05023
PDB IDs	7E1Z 7E20 7E21
GO Terms Enriched among Interactors ?	Positive Regulation Of Sodium Ion Export Across Plasma Membrane Ion Channel Regulator Activity Response To Epidermal Growth Factor Regulation Of Transport Positive Regulation Of Sodium Ion Transmembrane Transport Positive Regulation Of Autophagosome-lysosome Fusion ERBB2 Signaling Pathway Regulation Of Vesicle-mediated Transport Positive Regulation Of Transport Interleukin-34-mediated Signaling Pathway Cellular Response To Tumor Necrosis Factor Sodium Channel Regulator Activity Intracellular Monoatomic Ion Homeostasis Regulation Of Cell Population Proliferation Positive Regulation Of Sodium Ion Transport Intracellular Monoatomic Cation Homeostasis Negative Regulation Of Developmental Process Regulation Of Golgi Inheritance Regulation Of Sodium Ion Transmembrane Transport Response To Tumor Necrosis Factor Caveolin-mediated Endocytosis Positive Regulation Of Macrophage Proliferation Monoatomic Cation Homeostasis Monoatomic Ion Homeostasis Cardiac Neural Crest Cell Development Involved In Heart Development Trachea Formation Positive Regulation Of Cellular Component Organization Intracellular Chemical Homeostasis Regulation Of Protein Metabolic Process Chemical Homeostasis Positive Regulation Of Cell Motility Outer Ear Morphogenesis ERBB3 Signaling Pathway ERBB2-ERBB3 Signaling Pathway Sodium Ion Transport Positive Regulation Of Locomotion Epidermal Growth Factor Receptor Signaling Pathway Bergmann Glial Cell Differentiation Sodium:potassium-exchanging ATPase Complex Regulation Of Sodium Ion Transport Homeostatic Process Cellular Homeostasis Caveola ERBB Signaling Pathway Negative Regulation Of Cell Differentiation Focal Adhesion Morphogenesis Of An Epithelial Fold Regulation Of Cellular PH MAP Kinase Activity Regulation Of Golgi Organization