ATP1A1 and FXYD2

Number of citations of the paper that reports this interaction (PubMedID 11832419)
0

Data Source:
HPRD (in vivo)

		ATP1A1	FXYD2
Description		ATPase Na+/K+ transporting subunit alpha 1	FXYD domain containing ion transport regulator 2
Image
GO Annotations	Cellular Component	Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Sodium:potassium-exchanging ATPase Complex Postsynaptic Density Membrane Basolateral Plasma Membrane Apical Plasma Membrane Lateral Plasma Membrane T-tubule Axon Organelle Membrane Protein-containing Complex Sperm Flagellum Sarcolemma Melanosome Cell Projection Membrane Raft Photoreceptor Inner Segment Membrane Extracellular Exosome Extracellular Vesicle	Plasma Membrane Sodium:potassium-exchanging ATPase Complex Membrane Basolateral Plasma Membrane Extracellular Exosome
	Molecular Function	Nucleotide Binding P-type Sodium:potassium-exchanging Transporter Activity Protein Binding ATP Binding P-type Potassium Transmembrane Transporter Activity Phosphatase Activity ATP Hydrolysis Activity Potassium Ion Binding Sodium Ion Binding Transmembrane Transporter Binding Metal Ion Binding Protein Heterodimerization Activity Protein-folding Chaperone Binding Steroid Hormone Binding	ATPase Activator Activity Protein Binding Sodium Channel Regulator Activity Protein-macromolecule Adaptor Activity Ion Channel Regulator Activity
	Biological Process	Regulation Of The Force Of Heart Contraction Regulation Of Sodium Ion Transport Monoatomic Ion Transport Potassium Ion Transport Sodium Ion Transport Intracellular Sodium Ion Homeostasis Osmosensory Signaling Pathway Regulation Of Blood Pressure Response To Xenobiotic Stimulus Establishment Or Maintenance Of Transmembrane Electrochemical Gradient Intracellular Monoatomic Cation Homeostasis Intracellular Potassium Ion Homeostasis Negative Regulation Of Glucocorticoid Biosynthetic Process Sodium Ion Transmembrane Transport Sodium Ion Export Across Plasma Membrane Negative Regulation Of Heart Contraction Positive Regulation Of Heart Contraction Positive Regulation Of Striated Muscle Contraction Sodium Ion Homeostasis Relaxation Of Cardiac Muscle Heart Contraction Cellular Response To Steroid Hormone Stimulus Potassium Ion Transmembrane Transport Cardiac Muscle Cell Action Potential Involved In Contraction Membrane Repolarization Membrane Repolarization During Cardiac Muscle Cell Action Potential Cell Communication By Electrical Coupling Involved In Cardiac Conduction Proton Transmembrane Transport Response To Glycoside Potassium Ion Import Across Plasma Membrane	Monoatomic Ion Transport Potassium Ion Transport Sodium Ion Transport Intracellular Sodium Ion Homeostasis Negative Regulation Of Cell Population Proliferation Establishment Or Maintenance Of Transmembrane Electrochemical Gradient Intracellular Potassium Ion Homeostasis Sodium Ion Export Across Plasma Membrane Regulation Of Monoatomic Ion Transport Transmembrane Transport Cellular Hyperosmotic Salinity Response Inorganic Cation Transmembrane Transport Proton Transmembrane Transport Positive Regulation Of Sodium Ion Export Across Plasma Membrane Potassium Ion Import Across Plasma Membrane
Pathways		Ion homeostasis Ion transport by P-type ATPases Potential therapeutics for SARS	Ion homeostasis Ion transport by P-type ATPases Potential therapeutics for SARS
Drugs		Digoxin Acetyldigitoxin Hydroflumethiazide Etacrynic acid Trichlormethiazide Deslanoside Ouabain Diazoxide Bretylium Ciclopirox Bepridil Potassium cation Aluminium Magnesium cation Digitoxin Almitrine Istaroxime Bisacodyl Magnesium acetate Potassium acetate Potassium sulfate Potassium Magnesium levulinate Magnesium lactate Aluminium phosphate Aluminum acetate Tegoprazan	Cyclothiazide Bisacodyl Thimerosal Tegoprazan
Diseases
GWAS		Coffee consumption ( 29367735) HDL cholesterol levels in HIV infection ( 33109212) Hip index ( 34021172) Macular thickness ( 30535121)	Hippocampal volume in Alzheimer's disease dementia ( 29274321) Myopia ( 27182965) Refractive error ( 32231278)
Interacting Genes		21 interacting genes: A2M ADD1 CEBPA CFL1 EGFR EZH2 FNDC3B FXYD1 FXYD2 FXYD7 GPR35 HGS MAPK1 MAPK3 NDRG1 PRKCA RNF10 SNAPIN TPT1 ZNRF1 ZNRF2	6 interacting genes: ATP1A1 ERGIC3 RRS1 SGTA SLC22A1 SLC22A2
Entrez ID		476	486
HPRD ID		01662	03487
Ensembl ID		ENSG00000163399	ENSG00000137731
Uniprot IDs		P05023	P54710
PDB IDs		7E1Z 7E20 7E21	2MKV 7E1Z 7E20 7E21
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Sodium Ion Export Across Plasma Membrane Ion Channel Regulator Activity Response To Epidermal Growth Factor Regulation Of Transport Positive Regulation Of Sodium Ion Transmembrane Transport Positive Regulation Of Autophagosome-lysosome Fusion ERBB2 Signaling Pathway Regulation Of Vesicle-mediated Transport Positive Regulation Of Transport Interleukin-34-mediated Signaling Pathway Cellular Response To Tumor Necrosis Factor Sodium Channel Regulator Activity Intracellular Monoatomic Ion Homeostasis Regulation Of Cell Population Proliferation Positive Regulation Of Sodium Ion Transport Intracellular Monoatomic Cation Homeostasis Negative Regulation Of Developmental Process Regulation Of Golgi Inheritance Regulation Of Sodium Ion Transmembrane Transport Response To Tumor Necrosis Factor Caveolin-mediated Endocytosis Positive Regulation Of Macrophage Proliferation Monoatomic Cation Homeostasis Monoatomic Ion Homeostasis Cardiac Neural Crest Cell Development Involved In Heart Development Trachea Formation Positive Regulation Of Cellular Component Organization Intracellular Chemical Homeostasis Regulation Of Protein Metabolic Process Chemical Homeostasis Positive Regulation Of Cell Motility Outer Ear Morphogenesis ERBB3 Signaling Pathway ERBB2-ERBB3 Signaling Pathway Sodium Ion Transport Positive Regulation Of Locomotion Epidermal Growth Factor Receptor Signaling Pathway Bergmann Glial Cell Differentiation Sodium:potassium-exchanging ATPase Complex Regulation Of Sodium Ion Transport Homeostatic Process Cellular Homeostasis Caveola ERBB Signaling Pathway Negative Regulation Of Cell Differentiation Focal Adhesion Morphogenesis Of An Epithelial Fold Regulation Of Cellular PH MAP Kinase Activity Regulation Of Golgi Organization	Acetylcholine Transport Pyrimidine Nucleoside Transmembrane Transporter Activity Epinephrine Transport Spermidine Transmembrane Transport Putrescine Transport Spermidine Transmembrane Transporter Activity Putrescine Transmembrane Transporter Activity Acetylcholine Transmembrane Transporter Activity Spermidine Transport Thiamine Transmembrane Transporter Activity Thiamine Transport Quaternary Ammonium Group Transmembrane Transporter Activity Thiamine Transmembrane Transport Norepinephrine Uptake Xenobiotic Transport Across Blood-brain Barrier Toxin Transmembrane Transporter Activity Polyamine Transmembrane Transport Serotonin Uptake Norepinephrine Transport Prostaglandin Transmembrane Transporter Activity Monoamine Transmembrane Transporter Activity Establishment Or Maintenance Of Transmembrane Electrochemical Gradient Organic Cation Transmembrane Transporter Activity Catecholamine Uptake Dopamine Uptake Azole Transmembrane Transport Serotonin Transport Quaternary Ammonium Group Transport Prostaglandin Transport Pyrimidine-containing Compound Transmembrane Transport Neurotransmitter Transmembrane Transporter Activity Vitamin Transmembrane Transport Organic Anion Transmembrane Transporter Activity Dopamine Transport Neurotransmitter Reuptake Xenobiotic Transmembrane Transporter Activity Monoamine Transport Neurotransmitter Uptake Basolateral Plasma Membrane Purine-containing Compound Transmembrane Transport Vitamin Transport Xenobiotic Transport Circulatory System Process Export Across Plasma Membrane Apical Plasma Membrane Basal Plasma Membrane Lateral Plasma Membrane Transport Across Blood-brain Barrier Organic Cation Transport Fatty Acid Transport
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