CDCA8 and TTK

Number of citations of the paper that reports this interaction (PMID 18243099)
80

Data Source:
BioGRID (enzymatic study)

		CDCA8	TTK
Gene Name		cell division cycle associated 8	TTK protein kinase
Image
Gene Ontology Annotations	Cellular Component	Chromosome, Centromeric Region Nucleus Nucleolus Spindle Cytosol Chromocenter Midbody Chromosome Passenger Complex Protein Complex Intercellular Bridge	Spindle Membrane
	Molecular Function	Protein Binding	Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding
	Biological Process	Mitotic Cell Cycle Mitotic Metaphase Plate Congression Chromosome Organization Cell Division	Spindle Organization Mitotic Spindle Organization Mitotic Spindle Assembly Checkpoint Positive Regulation Of Cell Proliferation Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Peptidyl-tyrosine Phosphorylation Chromosome Separation
Pathways		Mitotic Prometaphase Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Mitotic Anaphase Mitotic Metaphase and Anaphase Cell Cycle, Mitotic M Phase
Drugs
Diseases
GWAS
Protein-Protein Interactions		14 interactors: AURKB BIRC5 HIST2H3C HLA-DRB3 INCENP MAPKAPK5 NEK3 RANBP2 SGOL1 SGOL2 SUMO1 SUMO2 TTK UBE2I	11 interactors: APP AZU1 CASC5 CDCA8 CDK2 CTD MAPK6 RPS6KA1 TP53 TUBB TUBB1
Entrez ID		55143	7272
HPRD ID		13017	04973
Ensembl ID		ENSG00000134690	ENSG00000112742
Uniprot IDs		Q53HL2	P33981
PDB IDs		2KDD 2QFA 2RAW 2RAX	2X9E 2ZMC 2ZMD 3CEK 3DBQ 3GFW 3H9F 3HMN 3HMO 3HMP 3VQU 3W1F 4B94 4BHZ 4BI0 4BI1 4BI2 4H7X 4H7Y
Enriched GO Terms of Interacting Partners?		Chromosome Segregation Mitotic Cell Cycle Cell Cycle Process Protein Sumoylation Mitotic Cell Cycle Process Cell Division Cell Cycle Mitotic Nuclear Division Organelle Organization Spindle Checkpoint Mitotic Spindle Organization Peptidyl-amino Acid Modification Peptidyl-lysine Modification Cellular Protein Modification Process Attachment Of Spindle Microtubules To Kinetochore Protein Modification By Small Protein Conjugation Cytokinesis Spindle Organization Mitotic Spindle Assembly Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Cellular Metabolic Process Microtubule Cytoskeleton Organization Cellular Protein Metabolic Process Regulation Of Proteasomal Protein Catabolic Process Post-translational Protein Modification Negative Regulation Of Transcription, DNA-templated Cell Cycle Checkpoint Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Cell Division Regulation Of Proteolysis Microtubule Anchoring Meiotic Sister Chromatid Cohesion, Centromeric Positive Regulation Of SUMO Transferase Activity Protein Phosphorylation Negative Regulation Of Gene Expression Nuclear Envelope Organization Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of Proteasomal Protein Catabolic Process Microtubule-based Process Meiotic Chromosome Segregation Negative Regulation Of Cell Division Regulation Of Chromosome Segregation Spindle Assembly Protein Metabolic Process Regulation Of Type B Pancreatic Cell Proliferation Regulation Of Protein Catabolic Process Negative Regulation Of Binding Histone H3-S28 Phosphorylation	Cell Cycle Cell Cycle Process Mitotic Cell Cycle Process Mitotic Cell Cycle Microtubule-based Process Negative Regulation Of Hydrolase Activity Cell Division Microtubule Cytoskeleton Organization Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Process Immune Response Regulation Of Cell Cycle Phase Transition Cell Cycle Checkpoint Positive Regulation Of Cell Cycle Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Catalytic Activity DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Neuron Apoptotic Process Positive Regulation Of Cellular Biosynthetic Process Mitotic Nuclear Division Signal Transduction Involved In DNA Damage Checkpoint Signal Transduction Involved In Cell Cycle Checkpoint Neuron Death Mitotic G1 DNA Damage Checkpoint Mitotic G1/S Transition Checkpoint G1 DNA Damage Checkpoint Positive Regulation Of Cell Cycle Arrest Positive Regulation Of Fractalkine Biosynthetic Process Positive Regulation Of Interleukin-1 Beta Biosynthetic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Spindle Assembly Regulation Of Mitotic Cell Cycle Chromosome Organization Cellular Component Assembly Protein Complex Assembly Response To Oxidative Stress Blood Coagulation Hemostasis Signal Transduction In Response To DNA Damage Mitotic DNA Damage Checkpoint Organelle Organization Regulation Of Cell Cycle Arrest Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Mitotic DNA Integrity Checkpoint Cytoskeleton Organization Negative Regulation Of Macromitophagy Synaptic Growth At Neuromuscular Junction Positive Regulation Of Hepatic Stellate Cell Activation Oligodendrocyte Apoptotic Process
Tagcloud ?		allele aurkb birc5 consortium contribution cpc division european exon familial fifteen fixed genotyped incenp inherited investigates meta modest passenger pivotal rs1675126 rs2071214 snp snps spite sporadic synonymous top variability	amongst brdu ca centrosome conversely discerning downregulated duplication explored hcc1954 incorporation instability kaplan knockdown manipulation mcf10a mdm2 meier microarray modulators novelty plot pursued resource sfrp1 sgol1 subtype tumorigenic upregulated
Tagcloud (Difference) ?		allele aurkb birc5 consortium contribution cpc division european exon familial fifteen fixed genotyped incenp inherited investigates meta modest passenger pivotal rs1675126 rs2071214 snp snps spite sporadic synonymous top variability	amongst brdu ca centrosome conversely discerning downregulated duplication explored hcc1954 incorporation instability kaplan knockdown manipulation mcf10a mdm2 meier microarray modulators novelty plot pursued resource sfrp1 sgol1 subtype tumorigenic upregulated
Tagcloud (Intersection) ?