CDCA8 and FBXO17

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CDCA8	FBXO17
Description		cell division cycle associated 8	F-box protein 17
Image			No pdb structure
GO Annotations	Cellular Component	Chromosome, Centromeric Region Nucleus Nucleoplasm Chromosome Nucleolus Cytoplasm Spindle Cytosol Cytoskeleton Chromocenter Microtubule Cytoskeleton Midbody Chromosome Passenger Complex Protein-containing Complex Intercellular Bridge Spindle Midzone	Cytoplasm Cytosol SCF Ubiquitin Ligase Complex
	Molecular Function	Protein Binding	Protein Binding Ubiquitin Protein Ligase Activity
	Biological Process	Mitotic Sister Chromatid Segregation Mitotic Cell Cycle Mitotic Cytokinesis Mitotic Metaphase Chromosome Alignment Mitotic Spindle Midzone Assembly Chromosome Organization Cell Division Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Mitotic Spindle Assembly Positive Regulation Of Mitotic Sister Chromatid Separation Positive Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Positive Regulation Of Mitotic Cytokinesis	Glycoprotein Catabolic Process SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process ERAD Pathway
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion SUMOylation of DNA replication proteins RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation	Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Axial length ( 24144296) Eyebrow thickness ( 26926045)	SAPHO syndrome ( 33816493)
Interacting Genes		28 interacting genes: AURKB BIRC5 EMILIN1 FBXO17 GAS2L3 GYS1 H3C14 HLA-DRB3 HMBOX1 INCENP KMT2E MAPKAPK5 NEK3 NKAPD1 NTAQ1 PIAS2 PIH1D2 RANBP2 RPRD1B SENP3 SET SGO1 SGO2 SNAPC5 SPANXN2 TTK UBE2I ZNF277	22 interacting genes: ADAMTSL4 ADRB2 CBY2 CDCA8 DZIP3 EIF4H JRK KPRP KRT75 KRTAP13-2 LASP1 OAS2 PTPN21 RAB11FIP2 RUNX1 SAXO1 SAXO2 SKP1 USP54 ZNF213 ZNF829 ZSCAN9
Entrez ID		55143	115290
HPRD ID		13017	16436
Ensembl ID		ENSG00000134690	ENSG00000269190
Uniprot IDs		Q53HL2	Q96EF6
PDB IDs		2KDD 2QFA 2RAW 2RAX 6YIE 6YIF 6YIH 7U5V 8RUP 8RUQ
Enriched GO Terms of Interacting Partners?		Chromosome Segregation Chromosome Passenger Complex Positive Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Kinetochore Mitotic Spindle Midzone Assembly Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Positive Regulation Of Attachment Of Spindle Microtubules To Kinetochore Spindle Midzone Assembly Positive Regulation Of Mitotic Cytokinesis Regulation Of Metaphase Plate Congression Regulation Of Mitotic Cytokinesis Nuclear Body Repair Of Mitotic Kinetochore Microtubule Attachment Defect Regulation Of Mitotic Sister Chromatid Separation Positive Regulation Of Cell Cycle Checkpoint SUMO Transferase Activity Chromosome, Centromeric Region Regulation Of Attachment Of Spindle Microtubules To Kinetochore Positive Regulation Of Mitotic Sister Chromatid Separation Cell Division Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Regulation Of Chromosome Separation Chromosome Regulation Of Mitotic Metaphase/anaphase Transition Positive Regulation Of Chromosome Segregation SUMO Ligase Complex Mitotic Spindle Organization Positive Regulation Of Chromosome Separation Regulation Of Sister Chromatid Segregation Regulation Of Mitotic Nuclear Division Regulation Of Chromosome Organization Positive Regulation Of Cytokinesis Mitotic Spindle Assembly Microtubule Cytoskeleton Organization Involved In Mitosis Regulation Of Chromosome Segregation Mitotic Cell Cycle Regulation Of Nuclear Division Protein Sumoylation Nucleoplasm Spindle Organization Mitotic Cytokinesis Chromocenter Regulation Of Mitotic Cell Cycle Phase Transition SUMO Ligase Activity Protein Localization To Kinetochore Meiotic Chromosome Segregation Nucleus Regulation Of Cytokinesis Condensed Chromosome, Centromeric Region
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