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CDCA8 and HLA-DRB3
Number of citations of the paper that reports this interaction (PMID
21988832
)
14
Data Source:
BioGRID
(two hybrid)
CDCA8
HLA-DRB3
Gene Name
cell division cycle associated 8
major histocompatibility complex, class II, DR beta 3
Image
Gene Ontology Annotations
Cellular Component
Chromosome, Centromeric Region
Nucleus
Nucleolus
Spindle
Cytosol
Chromocenter
Midbody
Chromosome Passenger Complex
Protein Complex
Intercellular Bridge
Golgi Membrane
Lysosomal Membrane
Plasma Membrane
Integral Component Of Plasma Membrane
External Side Of Plasma Membrane
ER To Golgi Transport Vesicle Membrane
Membrane
Transport Vesicle Membrane
Endocytic Vesicle Membrane
Clathrin-coated Endocytic Vesicle Membrane
Late Endosome Membrane
Trans-Golgi Network Membrane
MHC Class II Protein Complex
Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane
Molecular Function
Protein Binding
Protein Binding
MHC Class II Receptor Activity
Peptide Antigen Binding
Biological Process
Mitotic Cell Cycle
Mitotic Metaphase Plate Congression
Chromosome Organization
Cell Division
Immunoglobulin Production Involved In Immunoglobulin Mediated Immune Response
Inflammatory Response To Antigenic Stimulus
Humoral Immune Response Mediated By Circulating Immunoglobulin
Immune Response
Signal Transduction
Detection Of Bacterium
Cytokine-mediated Signaling Pathway
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II
T Cell Costimulation
Regulation Of Interleukin-4 Production
Negative Regulation Of Interferon-gamma Production
Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus
T-helper 1 Type Immune Response
Negative Regulation Of T Cell Proliferation
T Cell Receptor Signaling Pathway
Protein Tetramerization
Interferon-gamma-mediated Signaling Pathway
Regulation Of Interleukin-10 Secretion
Pathways
Mitotic Prometaphase
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
Mitotic Anaphase
Mitotic Metaphase and Anaphase
Cell Cycle, Mitotic
M Phase
Generation of second messenger molecules
Downstream TCR signaling
Costimulation by the CD28 family
Translocation of ZAP-70 to Immunological synapse
Interferon Signaling
Cytokine Signaling in Immune system
Interferon gamma signaling
TCR signaling
MHC class II antigen presentation
PD-1 signaling
Phosphorylation of CD3 and TCR zeta chains
Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions
14 interactors:
AURKB
BIRC5
HIST2H3C
HLA-DRB3
INCENP
MAPKAPK5
NEK3
RANBP2
SGOL1
SGOL2
SUMO1
SUMO2
TTK
UBE2I
4 interactors:
CDCA8
CTAG1B
MAP3K13
POMC
Entrez ID
55143
3125
HPRD ID
13017
09985
Ensembl ID
ENSG00000134690
Uniprot IDs
Q53HL2
P79483
PDB IDs
2KDD
2QFA
2RAW
2RAX
2Q6W
3C5J
4H1L
Enriched GO Terms of Interacting Partners
?
Chromosome Segregation
Mitotic Cell Cycle
Cell Cycle Process
Protein Sumoylation
Mitotic Cell Cycle Process
Cell Division
Cell Cycle
Mitotic Nuclear Division
Organelle Organization
Spindle Checkpoint
Mitotic Spindle Organization
Peptidyl-amino Acid Modification
Peptidyl-lysine Modification
Cellular Protein Modification Process
Attachment Of Spindle Microtubules To Kinetochore
Protein Modification By Small Protein Conjugation
Cytokinesis
Spindle Organization
Mitotic Spindle Assembly
Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Cellular Metabolic Process
Microtubule Cytoskeleton Organization
Cellular Protein Metabolic Process
Regulation Of Proteasomal Protein Catabolic Process
Post-translational Protein Modification
Negative Regulation Of Transcription, DNA-templated
Cell Cycle Checkpoint
Negative Regulation Of Nucleic Acid-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Regulation Of Cell Division
Regulation Of Proteolysis
Microtubule Anchoring
Meiotic Sister Chromatid Cohesion, Centromeric
Positive Regulation Of SUMO Transferase Activity
Protein Phosphorylation
Negative Regulation Of Gene Expression
Nuclear Envelope Organization
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Biosynthetic Process
Positive Regulation Of Proteasomal Protein Catabolic Process
Microtubule-based Process
Meiotic Chromosome Segregation
Negative Regulation Of Cell Division
Regulation Of Chromosome Segregation
Spindle Assembly
Protein Metabolic Process
Regulation Of Type B Pancreatic Cell Proliferation
Regulation Of Protein Catabolic Process
Negative Regulation Of Binding
Histone H3-S28 Phosphorylation
Tagcloud
?
allele
aurkb
birc5
consortium
contribution
cpc
division
european
exon
familial
fifteen
fixed
genotyped
incenp
inherited
investigates
meta
modest
passenger
pivotal
rs1675126
rs2071214
snp
snps
spite
sporadic
synonymous
top
variability
Tagcloud (Difference)
?
allele
aurkb
birc5
consortium
contribution
cpc
division
european
exon
familial
fifteen
fixed
genotyped
incenp
inherited
investigates
meta
modest
passenger
pivotal
rs1675126
rs2071214
snp
snps
spite
sporadic
synonymous
top
variability
Tagcloud (Intersection)
?