CDCA8 and EMILIN1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CDCA8	EMILIN1
Description		cell division cycle associated 8	elastin microfibril interfacer 1
Image
GO Annotations	Cellular Component	Chromosome, Centromeric Region Nucleus Nucleoplasm Chromosome Nucleolus Cytoplasm Spindle Cytosol Cytoskeleton Chromocenter Microtubule Cytoskeleton Midbody Chromosome Passenger Complex Protein-containing Complex Intercellular Bridge Spindle Midzone	Extracellular Region Collagen Trimer Extracellular Space Extracellular Matrix Integrin Alpha4-beta1 Complex Extracellular Exosome EMILIN Complex
	Molecular Function	Protein Binding	Extracellular Matrix Structural Constituent Protein Binding Extracellular Matrix Constituent Conferring Elasticity Identical Protein Binding Molecular Adaptor Activity Integrin Binding Involved In Cell-matrix Adhesion
	Biological Process	Mitotic Sister Chromatid Segregation Mitotic Cell Cycle Mitotic Cytokinesis Mitotic Metaphase Chromosome Alignment Mitotic Spindle Midzone Assembly Chromosome Organization Cell Division Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Mitotic Spindle Assembly Positive Regulation Of Mitotic Sister Chromatid Separation Positive Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Positive Regulation Of Mitotic Cytokinesis	Aortic Valve Morphogenesis Cell Adhesion Cell-matrix Adhesion Regulation Of Blood Pressure Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Positive Regulation Of Cell-substrate Adhesion Cell Migration Negative Regulation Of Angiogenesis Positive Regulation Of Blood Coagulation Extracellular Matrix Organization Negative Regulation Of Cell Migration Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Negative Regulation Of Collagen Biosynthetic Process Cell Adhesion Mediated By Integrin Regulation Of Cell Population Proliferation Positive Regulation Of Apoptotic Process Positive Regulation Of Angiogenesis Elastic Fiber Assembly Negative Regulation Of Cell Activation Negative Regulation Of SMAD Protein Signal Transduction Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Defense Response To Bacterium Negative Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Positive Regulation Of Extracellular Matrix Assembly Positive Regulation Of Platelet Aggregation Negative Regulation Of Collagen Fibril Organization Negative Regulation Of Macrophage Migration
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion SUMOylation of DNA replication proteins RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation	Molecules associated with elastic fibres Molecules associated with elastic fibres
Drugs
Diseases
GWAS		Axial length ( 24144296) Eyebrow thickness ( 26926045)	Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		28 interacting genes: AURKB BIRC5 EMILIN1 FBXO17 GAS2L3 GYS1 H3C14 HLA-DRB3 HMBOX1 INCENP KMT2E MAPKAPK5 NEK3 NKAPD1 NTAQ1 PIAS2 PIH1D2 RANBP2 RPRD1B SENP3 SET SGO1 SGO2 SNAPC5 SPANXN2 TTK UBE2I ZNF277	28 interacting genes: ABI3 BEX3 BEX5 BFSP1 CDCA8 CENPQ COG7 DYNC1I1 EMILIN2 FBXO28 GNG13 IFT20 LAIR2 LRRIQ1 MIA2 MTMR9 NECAB2 NMI PLAC9 PRKAA2 RABGEF1 RIBC1 SNAPC5 TAB2 TSNAX YJU2 ZC2HC1C ZNF655
Entrez ID		55143	11117
HPRD ID		13017	00563
Ensembl ID		ENSG00000134690	ENSG00000138080
Uniprot IDs		Q53HL2	Q9Y6C2
PDB IDs		2KDD 2QFA 2RAW 2RAX 6YIE 6YIF 6YIH 7U5V 8RUP 8RUQ	2KA3 2OII
Enriched GO Terms of Interacting Partners?		Chromosome Segregation Chromosome Passenger Complex Positive Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Kinetochore Mitotic Spindle Midzone Assembly Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Positive Regulation Of Attachment Of Spindle Microtubules To Kinetochore Spindle Midzone Assembly Positive Regulation Of Mitotic Cytokinesis Regulation Of Metaphase Plate Congression Regulation Of Mitotic Cytokinesis Nuclear Body Repair Of Mitotic Kinetochore Microtubule Attachment Defect Regulation Of Mitotic Sister Chromatid Separation Positive Regulation Of Cell Cycle Checkpoint SUMO Transferase Activity Chromosome, Centromeric Region Regulation Of Attachment Of Spindle Microtubules To Kinetochore Positive Regulation Of Mitotic Sister Chromatid Separation Cell Division Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Regulation Of Chromosome Separation Chromosome Regulation Of Mitotic Metaphase/anaphase Transition Positive Regulation Of Chromosome Segregation SUMO Ligase Complex Mitotic Spindle Organization Positive Regulation Of Chromosome Separation Regulation Of Sister Chromatid Segregation Regulation Of Mitotic Nuclear Division Regulation Of Chromosome Organization Positive Regulation Of Cytokinesis Mitotic Spindle Assembly Microtubule Cytoskeleton Organization Involved In Mitosis Regulation Of Chromosome Segregation Mitotic Cell Cycle Regulation Of Nuclear Division Protein Sumoylation Nucleoplasm Spindle Organization Mitotic Cytokinesis Chromocenter Regulation Of Mitotic Cell Cycle Phase Transition SUMO Ligase Activity Protein Localization To Kinetochore Meiotic Chromosome Segregation Nucleus Regulation Of Cytokinesis Condensed Chromosome, Centromeric Region	A2A Adenosine Receptor Binding
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