CDCA8 and SGO1

Number of citations of the paper that reports this interaction (PubMedID 20739936)
0

Data Source:
BioGRID (two hybrid)

		CDCA8	SGO1
Description		cell division cycle associated 8	shugoshin 1
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GO Annotations	Cellular Component	Chromosome, Centromeric Region Nucleus Nucleoplasm Chromosome Nucleolus Cytoplasm Spindle Cytosol Cytoskeleton Chromocenter Microtubule Cytoskeleton Midbody Chromosome Passenger Complex Protein-containing Complex Intercellular Bridge Spindle Midzone	Chromosome, Centromeric Region Kinetochore Condensed Chromosome, Centromeric Region Spindle Pole Nucleus Nucleoplasm Chromosome Cytoplasm Centrosome Cytosol Cytoskeleton Nuclear Speck
	Molecular Function	Protein Binding	Protein Binding Kinase Binding
	Biological Process	Mitotic Sister Chromatid Segregation Mitotic Cell Cycle Mitotic Cytokinesis Mitotic Metaphase Chromosome Alignment Mitotic Spindle Midzone Assembly Chromosome Organization Cell Division Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Mitotic Spindle Assembly Positive Regulation Of Mitotic Sister Chromatid Separation Positive Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Positive Regulation Of Mitotic Cytokinesis	Chromosome Segregation Attachment Of Spindle Microtubules To Kinetochore Centriole-centriole Cohesion Meiotic Chromosome Segregation Cell Division Mitotic Sister Chromatid Cohesion, Centromeric
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion SUMOylation of DNA replication proteins RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase Cyclin A/B1/B2 associated events during G2/M transition EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		Axial length ( 24144296) Eyebrow thickness ( 26926045)
Interacting Genes		28 interacting genes: AURKB BIRC5 EMILIN1 FBXO17 GAS2L3 GYS1 H3C14 HLA-DRB3 HMBOX1 INCENP KMT2E MAPKAPK5 NEK3 NKAPD1 NTAQ1 PIAS2 PIH1D2 RANBP2 RPRD1B SENP3 SET SGO1 SGO2 SNAPC5 SPANXN2 TTK UBE2I ZNF277	21 interacting genes: CDCA8 LRRC59 PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E PRKDC PTPA RPL10A RPL28 RPL7 RPL7A RPLP1 SET XRCC5 XRCC6
Entrez ID		55143	151648
HPRD ID		13017	12377
Ensembl ID		ENSG00000134690	ENSG00000129810
Uniprot IDs		Q53HL2	B5BUA4 Q5FBB7
PDB IDs		2KDD 2QFA 2RAW 2RAX 6YIE 6YIF 6YIH 7U5V 8RUP 8RUQ	3FGA 3Q6S 4A0I 7ZJS
Enriched GO Terms of Interacting Partners?		Chromosome Segregation Chromosome Passenger Complex Positive Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Kinetochore Mitotic Spindle Midzone Assembly Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Positive Regulation Of Attachment Of Spindle Microtubules To Kinetochore Spindle Midzone Assembly Positive Regulation Of Mitotic Cytokinesis Regulation Of Metaphase Plate Congression Regulation Of Mitotic Cytokinesis Nuclear Body Repair Of Mitotic Kinetochore Microtubule Attachment Defect Regulation Of Mitotic Sister Chromatid Separation Positive Regulation Of Cell Cycle Checkpoint SUMO Transferase Activity Chromosome, Centromeric Region Regulation Of Attachment Of Spindle Microtubules To Kinetochore Positive Regulation Of Mitotic Sister Chromatid Separation Cell Division Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Regulation Of Chromosome Separation Chromosome Regulation Of Mitotic Metaphase/anaphase Transition Positive Regulation Of Chromosome Segregation SUMO Ligase Complex Mitotic Spindle Organization Positive Regulation Of Chromosome Separation Regulation Of Sister Chromatid Segregation Regulation Of Mitotic Nuclear Division Regulation Of Chromosome Organization Positive Regulation Of Cytokinesis Mitotic Spindle Assembly Microtubule Cytoskeleton Organization Involved In Mitosis Regulation Of Chromosome Segregation Mitotic Cell Cycle Regulation Of Nuclear Division Protein Sumoylation Nucleoplasm Spindle Organization Mitotic Cytokinesis Chromocenter Regulation Of Mitotic Cell Cycle Phase Transition SUMO Ligase Activity Protein Localization To Kinetochore Meiotic Chromosome Segregation Nucleus Regulation Of Cytokinesis Condensed Chromosome, Centromeric Region	Protein Phosphatase Type 2A Complex Protein Phosphatase Regulator Activity Protein Phosphatase Activator Activity Meiotic Sister Chromatid Cohesion Chromosome Organization Cytosolic Large Ribosomal Subunit DNA-dependent Protein Kinase Complex Chromosome, Centromeric Region DNA-dependent Protein Kinase-DNA Ligase 4 Complex Nonhomologous End Joining Complex Cytosolic Ribosome Sister Chromatid Cohesion Cytosol Cytoplasmic Translation Nucleus Structural Constituent Of Ribosome FAR/SIN/STRIPAK Complex Chromosome DNA End Binding Ku70:Ku80 Complex Ribosome Small-subunit Processome Assembly Cytoplasm Ribonucleoprotein Complex Meiotic Sister Chromatid Cohesion, Centromeric Protein-DNA Complex 5'-deoxyribose-5-phosphate Lyase Activity Response To Gamma Radiation Nuclear Telomere Cap Complex Double-stranded Telomeric DNA Binding Macromolecule Biosynthetic Process Spindle Organization Double-strand Break Repair Via Nonhomologous End Joining Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Ribonucleoprotein Complex Biogenesis Translation U3 SnoRNA Binding Protein Serine/threonine Phosphatase Activity INTAC Complex Spindle Assembly Response To Lead Ion Telomere Maintenance RNA Polymerase II Transcription Initiation Surveillance Negative Regulation Of Hippo Signaling Ribosome Biogenesis Hyperosmotic Response RNA Binding Maturation Of LSU-rRNA Telomeric DNA Binding Cellular Response To Gamma Radiation
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