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NEFL and MYO5A
Number of citations of the paper that reports this interaction (PubMedID
12403814
)
50
Data Source:
HPRD
(in vivo, in vitro)
NEFL
MYO5A
Description
neurofilament light chain
myosin VA
Image
No pdb structure
GO Annotations
Cellular Component
Cytoplasm
Cytosol
Cytoskeleton
Intermediate Filament
Neurofilament
Axon
Growth Cone
Neuromuscular Junction
Cell Projection
Neuron Projection
Intermediate Filament Cytoskeleton
Schaffer Collateral - CA1 Synapse
Cholinergic Synapse
Postsynaptic Intermediate Filament Cytoskeleton
Presynaptic Intermediate Filament Cytoskeleton
Axon Cytoplasm
Ruffle
Cytoplasm
Lysosome
Early Endosome
Late Endosome
Peroxisome
Endoplasmic Reticulum
Cytosol
Actin Filament
Actin Cytoskeleton
Membrane
Myosin Complex
Growth Cone
Cytoplasmic Vesicle
Vesicle
Filopodium Tip
Insulin-responsive Compartment
Melanosome
Neuron Projection
Recycling Endosome
Extracellular Exosome
Molecular Function
Structural Constituent Of Cytoskeleton
Protein Binding
Tubulin Binding
Protein Domain Specific Binding
Protein-macromolecule Adaptor Activity
Identical Protein Binding
Phospholipase Binding
Protein-containing Complex Binding
Structural Constituent Of Postsynaptic Intermediate Filament Cytoskeleton
Microfilament Motor Activity
Nucleotide Binding
RNA Binding
Cytoskeletal Motor Activity
Actin Binding
Catalytic Activity
Protein Binding
Calmodulin Binding
ATP Binding
ATP Hydrolysis Activity
Small GTPase Binding
Actin Filament Binding
Biological Process
Microtubule Cytoskeleton Organization
Axonogenesis
Anterograde Axonal Transport
Retrograde Axonal Transport
Response To Toxic Substance
Peripheral Nervous System Axon Regeneration
Axonal Transport Of Mitochondrion
Spinal Cord Development
Hippocampus Development
Cerebral Cortex Development
Regulation Of Axon Diameter
Neurofilament Bundle Assembly
Locomotion
Response To Peptide Hormone
Intermediate Filament Polymerization Or Depolymerization
Intermediate Filament Organization
Intermediate Filament Bundle Assembly
Neuron Projection Morphogenesis
Positive Regulation Of Axonogenesis
Neuromuscular Process Controlling Balance
Protein Polymerization
Response To Corticosterone
Neurofilament Cytoskeleton Organization
Regulation Of Synapse Maturation
Motor Neuron Apoptotic Process
Postsynaptic Modulation Of Chemical Synaptic Transmission
Postsynaptic Intermediate Filament Cytoskeleton Organization
Response To Sodium Arsenite
Response To Acrylamide
Negative Regulation Of Motor Neuron Apoptotic Process
Post-Golgi Vesicle-mediated Transport
Endocytosis
Actin Filament Organization
Protein Transport
Vesicle-mediated Transport
Actin Filament-based Movement
Vesicle Transport Along Actin Filament
Melanosome Transport
Cellular Response To Insulin Stimulus
Protein Localization To Plasma Membrane
Regulation Of Golgi Organization
Pathways
Unblocking of NMDA receptors, glutamate binding and activation
Unblocking of NMDA receptors, glutamate binding and activation
Ras activation upon Ca2+ influx through NMDA receptor
RAF/MAP kinase cascade
Assembly and cell surface presentation of NMDA receptors
Negative regulation of NMDA receptor-mediated neuronal transmission
Long-term potentiation
Translocation of SLC2A4 (GLUT4) to the plasma membrane
Regulation of actin dynamics for phagocytic cup formation
Insulin processing
FCGR3A-mediated phagocytosis
Regulation of MITF-M-dependent genes involved in pigmentation
Regulation of MITF-M-dependent genes involved in pigmentation
Drugs
Diseases
Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
Other phagocyte defects, including the following eight diseases: Chediak-Higashi syndrome; Griscelli syndrome, type 1 (GS1); Griscelli syndrome, type 2 (GS2); Griscelli syndrome, type 3 (GS3); beta-actin deficiency; Neutrophil-specific granule deficiency; Myeloperoxidase deficiency; Glucose 6-phosphate dehydrogenase deficiency; Shwachman syndrome
GWAS
Fear of minor pain (
28701861
)
Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 2 peripheral neuropathy) (
24554482
)
Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 3 peripheral neuropathy) (
24554482
)
Mean platelet volume (
32888494
)
Metabolite levels (Pyroglutamine) (
23934736
)
Interacting Genes
55 interacting genes:
BRD7
CCDC13
CCDC172
CCDC33
CCNC
CDK5RAP2
CEP57L1
CHD3
DES
DSCAM
ENKD1
FXR1
GFAP
GOLGA2
GORASP1
GRIN1
HGS
ITSN1
KDM1A
KIFC3
KLC3
KRT13
KRT15
KRT18
MAP2
MTMR2
MTUS2
MYO15B
MYO5A
NDN
NEFH
NEIL3
NEK6
NME7
PDE4DIP
PIAS4
PKN1
PPP1R16B
PPP1R18
PRMT6
RBM11
SHANK3
SKIL
SMYD1
SPTAN1
TERF1
TEX11
TRIM55
TRIM63
TSC1
TXLNB
USHBP1
USP2
VIM
YWHAG
20 interacting genes:
AKAP9
BMF
CALM1
DLGAP1
DYNLL1
DYNLL2
ERG
KIF5B
MLPH
NDEL1
NEFL
PDE4B
PRPH
RAB11A
RAB27A
RAB3A
RPH3A
TRIM2
TRIM3
USP7
Entrez ID
4747
4644
HPRD ID
01206
01179
Ensembl ID
ENSG00000277586
ENSG00000197535
Uniprot IDs
P07196
A0A8I5KTF1
A0A8J8YWI7
A8CDT9
Q9UES4
Q9Y4I1
PDB IDs
4D07
4J5L
4LLI
4LX1
4LX2
5JCY
5JCZ
Enriched GO Terms of Interacting Partners
?
Cytoskeleton
Microtubule
Microtubule Binding
Intermediate Filament Cytoskeleton Organization
Intermediate Filament-based Process
Cytoskeleton Organization
Cytoplasm
Intermediate Filament Organization
Organelle Organization
Centrosome
Structural Constituent Of Cytoskeleton
Intermediate Filament
Cell Projection
Microtubule-based Process
Regulation Of Nervous System Development
Microtubule Cytoskeleton Organization
Regulation Of Cellular Component Organization
Neuron Projection
Centrosome Cycle
Intermediate Filament Cytoskeleton
Regulation Of Neurogenesis
Supramolecular Fiber Organization
Regulation Of Developmental Process
Regulation Of Microtubule Polymerization
Regulation Of Neuron Projection Development
Negative Regulation Of Cellular Component Organization
Positive Regulation Of Neurogenesis
Plasma Membrane Bounded Cell Projection Organization
Scaffold Protein Binding
Dendritic Spine
Cell Projection Organization
Microtubule Organizing Center Organization
Gamma-tubulin Binding
Protein Binding
Regulation Of Plasma Membrane Bounded Cell Projection Organization
Regulation Of Supramolecular Fiber Organization
Positive Regulation Of Nervous System Development
Regulation Of Cell Development
Regulation Of Cell Projection Organization
Microtubule Organizing Center
Regulation Of Cell Differentiation
Regulation Of Microtubule Polymerization Or Depolymerization
Regulation Of Organelle Organization
Regulation Of Organelle Transport Along Microtubule
Kinesin Binding
Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Positive Regulation Of Long-term Neuronal Synaptic Plasticity
Regulation Of Protein-containing Complex Assembly
Organelle Assembly
Calmodulin Binding
Establishment Of Vesicle Localization
Vesicle Localization
Establishment Of Organelle Localization
Organelle Localization
Axon Cytoplasm
Myosin V Binding
Establishment Of Localization In Cell
Retrograde Axonal Transport
Protein-containing Complex Binding
Establishment Of Melanosome Localization
Melanosome Localization
Melanosome Transport
Pigment Granule Transport
Pigment Granule Localization
Regulation Of Transport
Centrosome
Centrosome Localization
Exosomal Secretion
Synaptic Vesicle Transport
Microtubule Associated Complex
Synaptic Vesicle Membrane
Modulation Of Chemical Synaptic Transmission
Synaptic Vesicle
Microtubule-based Process
Positive Regulation Of Regulated Secretory Pathway
Lysosome Localization
Transport Along Microtubule
Vesicle
Axonal Transport
Neurofilament Cytoskeleton Organization
Microtubule-based Movement
Cytoskeleton-dependent Intracellular Transport
Cytosol
Microtubule-based Transport
Axo-dendritic Transport
Positive Regulation Of Exocytosis
Cytoskeleton
Organelle Transport Along Microtubule
Protein Transport
Vesicle-mediated Transport In Synapse
Intermediate Filament Cytoskeleton Organization
Intermediate Filament-based Process
Regulation Of Cellular Component Organization
Positive Regulation Of Cellular Component Organization
Organelle Organization
Secretory Granule
Regulation Of Intracellular Transport
Intracellular Transport
Regulation Of Cellular Localization
Regulation Of Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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